Keith A Niggemyer

University of Pittsburgh, Pittsburgh, Pennsylvania, United States

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Publications (1)4.59 Total impact

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    Keith A Niggemyer · Amy Begley · Timothy Monk · Daniel J Buysse
    [Show abstract] [Hide abstract]
    ABSTRACT: To identify age-associated changes in circadian and homeostatic characteristics of sleep in healthy elderly and young adults using electroencephalogram (EEG) power spectral analysis during a 90-minute sleep-wake schedule. Controlled clinical experiment. University sleep laboratory. 16 older (77 +/- 5 years) and 19 younger adults (23 +/- 3 years). Subjects followed a 90-minute sleep-wake schedule (30 minutes in bed, 60 minutes awake) for 60 hours. Sleep was recorded for each bed-rest episode, and core body temperature was continuously recorded. The EEG power density was determined for non-rapid eye movement sleep in each bed-rest episode. Power density data were analyzed with mixed-effects models to assess rhythmic and linear components. Younger subjects had greater power in delta, theta, and sigma power bands across the study interval. Significant circadian rhythms were observed in delta, sigma, and beta power bands. Age-related differences in circadian modulation of EEG activity, indicated by significant interaction terms, were present in alpha and beta bands. A significant linear component was present in delta and theta power bands, with no significant age-interaction effect. Despite overall differences in the level of EEG power, older and younger adults exhibited similar rhythmic and linear patterns in most frequency bands. Age appears to affect circadian rhythmicity in higher EEG frequencies and homeostatic drive in lower EEG frequencies.
    Preview · Article · Jan 2005 · Sleep

Publication Stats

23 Citations
4.59 Total Impact Points

Top Journals


  • 2005
    • University of Pittsburgh
      • Department of Psychiatry
      Pittsburgh, Pennsylvania, United States