K. M. Kamruzzaman Selim

Kyungpook National University, Daikyū, Daegu, South Korea

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Publications (6)41.78 Total impact

  • Hyun-Su Bae · Adnan Haider · K. M. Kamruzzaman Selim · Dong-Yoon Kang · Eun-Jin Kim · Inn-Kyu Kang
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    ABSTRACT: Highly porous polymethyl methacrylate (PMMA) fibers were fabricated via an electrospinning technique using a binary solvent system (8:2 dichloromethane:dimethylformamide) and controlled humidity. The electrospinning process was carried out in a closed hood under humid conditions (varying the humidity from 15 to 70 %). The effects of the concentration, electrospinning parameters, and humidity on the morphology of the PMMA fibers were assessed by field emission scanning electron microscopy (FE-SEM). The surface area, porosity, and mean interfiber pore size of membranes made from the fibers were measured with the Brunauer–Emmett–Teller (BET) method, and the diameter of the fibers was measured using an image analyzer. Nonporous and porous electrospun PMMA fibers exhibited concentration-dependent variations in their morphologies. No effect of the electrospinning parameters, such as the voltage and flow rate, was observed. The porosity of the PMMA fibers increased when the humidity was changed from 15 to 70 %. The porous PMMA fibers had a large surface area (139.0 m2/g) and a small interfiber pore size (34.8 Å), along with an average fiber diameter of 2 μm. The capacities of the porous and nonporous fibrous membranes to adsorb iodine and phenol were tested. The large surface areas of the membranes led to excellent adsorption capacity of the porous PMMA fiber membrane (iodine: 203 mg/g; phenol: 3.73 mg/g), in contrast to the adsorption capacities of the nonporous PMMA fiber membrane (iodine:117 mg/g; phenol: 1.8 mg/g). A facile, easily accessible approach for fabricating porous fiber membranes is presented in this work, and it is believed that the product may find potential application—as a possible substitute for conventional material—in the removal of organic and inorganic pollutants from water.
    No preview · Article · Jul 2013 · Journal of Polymer Research
  • K M Kamruzzaman Selim · Zhi-Cai Xing · Haiqing Guo · Inn-Kyu Kang
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    ABSTRACT: In the current study, beta-galactose-carrying lactobionic acid (LA) was conjugated on the surface of mercaptoacetic acid-coated cadmium sulfide nanoparticles (CSNPs) to ensure specific recognition of liver cells (hepatocytes) and to enhance biocompatibility. Maltotrionic acid-coated CSNPs (MCSNPs) were also prepared for use as a control. The results showed that LA-immobilized CSNPs (LCSNPs) were selectively and rapidly internalized into hepatocytes and emitted more intense fluorescence images as well as demonstrated increased biocompatible behavior in vitro than those of CSNPs and MCSNPs. Furthermore, the uptake amount of LCSNPs into hepatocytes was higher than that of CSNPs and MCSNPs. All these results indicate that LCSNPs may find ever-growing applications in biological labels and detection or contrast agents in life science and medical diagnostics.
    No preview · Article · May 2009 · Journal of Materials Science Materials in Medicine
  • Woo-Dong Jang · K. M. Kamruzzaman Selim · Chi-Hwa Lee · Inn-Kyu Kang
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    ABSTRACT: Over the past few years, utilization of dendrimers in nano-biotechnology applications such as bio-mimicry, diagnostics, and therapeutics has attracted a great deal of attention, far beyond that of other classical polymers and oligomers. The intensified interest in dendrimers is due to their unique characteristics, which include excellent structural uniformity, multivalency, high degree of branching, well-defined molecular architecture, and highly variable chemical composition. Indeed, dendrimers can possess many terminal functional groups that can be chemically linked to other moieties in order to adjust their surface properties for applications such as biomimetic nano-devices. Furthermore, by utilizing the homogeneity of their three-dimensional architecture, a variety of biologically active agents can be incorporated into dendrimers to form biologically active conjugates, including novel drug carriers. Here, we review several aspects of bio-inspired dendrimer applications, giving special focus to their use as protein mimics, drug and gene delivery agents, anticancer and antiviral therapeutics, and in biomedical diagnostic applications. We also provide a brief introduction to the preparation of dendrimers and review their physicochemical and biological properties.
    No preview · Article · Jan 2009 · Progress in Polymer Science
  • K. M. Kamruzzaman Selim · Yong-Soo Ha · Sun-Jung Kim · Yongmin Chang · Tae-Jeong Kim · Gang Ho Lee · Inn-Kyu Kang
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    ABSTRACT: In the current study, superparamagnetic magnetite nanoparticles were surface-modified with lactobionic acid (LA) to improve their intracellular uptake and ability to target hepatocytes. Maltotrionic acid (MA)-modified nanoparticles were also synthesized as a control. Cell culture experiment showed that LA-modified nanoparticles were internalized into hepatocytes and atomic absorption spectrometer (AAS) measurement indicated that the uptake amount of LA-modified magnetite into hepatocytes was higher than that of unmodified and MA-modified nanoparticles. LA-modified nanoparticle solution was injected in rabbit and the magnetic resonance (MR) images obtained showed that LA-coated nanoparticles were selectively accumulated onto the hepatocytes. This result demonstrates that the LA-modified magnetite nanoparticles have a great potential to be used as contrast agent for liver diagnosis.
    No preview · Article · Mar 2007 · Biomaterials
  • K. M. Kamruzzaman Selim · Mi Jin Park · Hong Mi Kim · Inn Kyu Kang
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    ABSTRACT: In the present study, superparamagnetic maltotrionic acid-coated magnetite nanoparticles (MAM) were surface modified with doxorubicin (DOX) and RGD peptide to improve their intracellular uptake, ability to target tumor cells and antitumer effect. RGD was added to the distal end of MAM aiming to construct an enhanced tumor targeting delivery system. To test its targeting effect, DOX, a widely used anticancer drug, was immobilized on the RGD-modified magnetite nanoparticles. DOX-coated magnetite nanoparticles were also prepared as a control. KB cell culture experiment showed that both DOX-modified nanoparticles and DOX-RGD peptide-modified magnetite nanoparticles (DRMAM) were internalized into the cells. But the uptake amount of DRMAMs was higher than that of DOX-modified nanoparticles. This result indicates that DRMAMs have a great potential to be used as contrast agent and antitumor medicine.
    No preview · Article · Jan 2007 · Key Engineering Materials
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    K. M. Kamruzzaman Selim · Joo-Hee Lee · Sun-Jung Kim · Zhicai Xing · Inn-Kyu Kang · Yongmin Chang · Haiqing Guo
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    ABSTRACT: Highly hydrophilic, uniform, superparamagnetic and nontoxic maltotrionic acid (MA)-coated magnetite nano-particles (MAM) were prepared and characterized by TEM, DLS, XRD and VSM. MA was used to improve the biocompatibility, monodispersity and non-specific intracellular uptake of nanoparticles. Folic acid (FA) was subsequently conjugated to the MAM to preferentially target KB cells (cancer cells) that have folate receptors expressed on their surfaces and to facilitate nanoparticles in their transit across the cell membrane. Finally, fluorescence isothiocyanate (FITC) was added to the nanoparticles to visualize the nanoparticle internalization into KB cells. After the cells were cultured in a media containing the MAM and MAM-folate conjugate (FAMAM), the results of fluorescence and confocal microscopy showed that both types of nanoparticles were internalized into the cells. Nevertheless, the amount of FAMAM uptake was higher than that of MAM. This result indicated that nanoparticles modified with MA and FA could be used to facilitate the nanoparticle uptake to specific KB cells (cancer cells) for molecular imaging.
    Preview · Article · Dec 2006 · Macromolecular Research