[Show abstract][Hide abstract] ABSTRACT: Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine
plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted
of 230 healthy individuals (108 children and 122 adults) having no acute or chronic disease. Plasma sEPCR levels were measured
with ELISA. Analysis revealed a bimodal distribution in both groups. There was a negative relationship between sEPCR levels
and the age of individuals (r=−0.385, P=0.0001). The sEPCR levels of children were found significantly higher than that of adults (P<0.001). This study is the first study to determine the relationship of sEPCR levels and terms of age. Higher levels of
sEPCR may suggest a regulation mechanism for the protein C anticoagulation system over the first years of life. Further studies
should be conducted to evaluate the physiological importance and molecular mechanism of increased sEPCR levels in children.
Full-text · Article · Jan 2010 · Journal of Thrombosis and Thrombolysis