Daniela Valdez-Jasso

University of Illinois at Chicago, Chicago, Illinois, United States

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Publications (12)15.86 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Right ventricular (RV) failure in response to pulmonary hypertension (PH) is a severe disease that remains poorly understood. PH-induced pressure overload leads to changes in the RV free wall (RVFW) that eventually results in RV failure. While the development of computational models can benefit our understanding of the onset and progression of PH-induced pressure overload, detailed knowledge of the underlying structural and biomechanical events remains limited. The goal of the present study was to elucidate the structural and biomechanical adaptations of RV myocardium subjected to sustained pressure overload in a rat model. Hemodynamically confirmed severe chronic RV pressure overload was induced in Sprague-Dawley rats via pulmonary artery banding. Extensive tissue-level biaxial mechanical and histomorphological analyses were conducted to assess the remodeling response in the RV free wall. Simultaneous myofiber hypertrophy and longitudinal re-orientation of myo- and collagen fibers were observed, with both fiber types becoming more highly aligned. Transmural myo- and collagen fiber orientations were co-aligned in both the normal and diseased state. The overall tissue stiffness increased, with larger increases in longitudinal vs. circumferential stiffness. The latter was attributed to longitudinal fiber re-orientation, which increased the degree of anisotropy. Increased mechanical coupling between the two axes was attributed to the increased fiber alignment. Interestingly, estimated myofiber stiffness increased while the collagen fiber stiffness remained unchanged. The increased myofiber stiffness was consistent with clinical results showing titin-associated increased sarcomeric stiffening observed in PH patients. These results further our understanding of the underlying adaptive and maladaptive remodeling mechanisms and may lead to improved techniques for prognosis, diagnosis, and treatment for PH.
    No preview · Article · Aug 2014 · Annals of Biomedical Engineering
  • Daniela Valdez-Jasso · Jeffrey J. Baust · Hunter C. Champion

    No preview · Conference Paper · May 2014
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    Daniela Valdez-Jasso · Marc A Simon · Hunter C Champion · Michael S Sacks
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    ABSTRACT: Key points  Right-ventricular (RV) function is an important determinant of cardio-pulmonary performance. How and when RV failure occurs in disease is poorly understood. RV biomechanics provides a means to understand tissue level behavior that links cellular mechanisms to organ level phenotype. RV biomechanics has received little attention.  We developed 1) rat model for quantifying the structure and biomechanical behavior of viable and transmurally intact RV tissue, and 2) a novel analysis method for obtaining representative scalar strain-energy function from stress-controlled biaxial experiments.  The mechanical testing revealed a marked mechanical tissue anisotropy with the apex-to-outflow tract direction being the stiffer direction.  The myo- and collagen fibers show a preferential alignment from the apex to the RV outflow tract direction with little transmural variation.  We found a strong relationship between normal tissue microstructure and biomechanical behavior, which lays the foundation for a detailed understanding of RV remodeling in response to disease.
    Full-text · Article · Jul 2012 · The Journal of Physiology
  • Daniela Valdez-Jasso · Marc A. Simon · Michael S. Sacks
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    ABSTRACT: Although right-ventricular (RV) function is an important determinant of cardio-pulmonary performance in health and disease, RV myocardium biomechanical function has received little attention. In particular, no multiaxial data of the full-thickness RV have been reported for the passive or active myocardial states, for either normal or pathological conditions. Since an understanding of tissue-level biomechanical behavior is integral to connecting cellular behavior to organ-level performance, investigations into the RV myocardial stress-strain relationship are central in providing this link. For example, ventricular wall stress is considered to be a major driver of ventricular remodeling, and thus a better understanding of how wall stress and deformation are linked would provide unique insights into the mechanisms of RV function and ultimately failure in disease. Such knowledge would have direct applicability to improving methods to detect RV dysfunction, predicting response to disease-specific therapies and improving the timing of therapy if or when needed. Here, we present a murine model of viable RVFW to obtain stable and robust mechanical data suitable for structural modeling. Our study determines the of window for viability of the RVFW samples, verifies uniformity of the structure, and carries biomechanical testing to determine stability and consistency of the data.
    No preview · Conference Paper · Jun 2012
  • Daniela Valdez-Jasso · Marc A. Simon · Michael S. Sacks
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    ABSTRACT: Although right-ventricular (RV) function is an important determinant of cardio-pulmonary performance in health and disease, RV myocardium biomechanical function has received little attention. In particular, no multiaxial data of the full-thickness RV have been reported for the passive or active myocardial states, for either normal or pathological conditions. Since an understanding of tissue-level biomechanical behavior is integral to connecting cellular behavior to organ-level performance, investigations into the RV myocardial stress-strain relationship are central in providing this link. For example, ventricular wall stress is considered to be a major driver of ventricular remodeling, and thus a better understanding of how wall stress and deformation are linked would provide unique insight into the mechanisms of RV function and ultimately failure in disease. Such knowledge would have direct applicability to improving methods to detect RV dysfunction, predicting response to disease-specific therapies and improving the timing of therapy if or when needed. Here, we present the first report on the multiaxial biomechanical behavior of viable full-thickness right-ventricular free wall (RVFW) myocardium and our initial efforts in developing a structural constitutive model for this remarkable tissue.
    No preview · Conference Paper · Jun 2011
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    ABSTRACT: A better understanding of the biomechanical properties of the arterial wall provides important insight into arterial vascular biology under normal (healthy) and pathological conditions. This insight has potential to improve tracking of disease progression and to aid in vascular graft design and implementation. In this study, we use linear and nonlinear viscoelastic models to predict biomechanical properties of the thoracic descending aorta and the carotid artery under ex vivo and in vivo conditions in ovine and human arteries. Models analyzed include a four-parameter (linear) Kelvin viscoelastic model and two five-parameter nonlinear viscoelastic models (an arctangent and a sigmoid model) that relate changes in arterial blood pressure to the vessel cross-sectional area (via estimation of vessel strain). These models were developed using the framework of Quasilinear Viscoelasticity (QLV) theory and were validated using measurements from the thoracic descending aorta and the carotid artery obtained from human and ovine arteries. In vivo measurements were obtained from 10 ovine aortas and 10 human carotid arteries. Ex vivo measurements (from both locations) were made in 11 male Merino sheep. Biomechanical properties were obtained through constrained estimation of model parameters. To further investigate the parameter estimates, we computed standard errors and confidence intervals and we used analysis of variance to compare results within and between groups. Overall, our results indicate that optimal model selection depends on the artery type. Results showed that for the thoracic descending aorta (under both experimental conditions), the best predictions were obtained with the nonlinear sigmoid model, while under healthy physiological pressure loading the carotid arteries nonlinear stiffening with increasing pressure is negligible, and consequently, the linear (Kelvin) viscoelastic model better describes the pressure-area dynamics in this vessel. Results comparing biomechanical properties show that the Kelvin and sigmoid models were able to predict the zero-pressure vessel radius; that under ex vivo conditions vessels are more rigid, and comparatively, that the carotid artery is stiffer than the thoracic descending aorta; and that the viscoelastic gain and relaxation parameters do not differ significantly between vessels or experimental conditions. In conclusion, our study demonstrates that the proposed models can predict pressure-area dynamics and that model parameters can be extracted for further interpretation of biomechanical properties.
    No preview · Article · May 2011 · Annals of Biomedical Engineering
  • Brooke N. Steele · Daniela Valdez-Jasso · Mansoor A. Haider · Mette S. Olufsen
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    ABSTRACT: This paper combines a generalized viscoelastic model with a one-dimensional (1D) fluid dynamics model for the prediction of blood flow, pressure, and vessel area in systemic arteries. The 1D fluid dynamics model is derived from the Navier—Stokes equations for an incompressible Newtonian flow through a network of cylindrical vessels. This model predicts pressure and flow and is combined with a viscoelastic constitutive equation derived using the quasilinear viscoelasticity theory that relates pressure and vessel area. This formulation allows for inclusion of an elastic response as well as an appropriate creep function allowing for the description of the viscoelastic deformation of the arterial wall. Three constitutive models were investigated: a linear elastic model and two viscoelastic models. The Kelvin and sigmoidal viscoelastic models provide linear and nonlinear elastic responses, respectively. For the fluid domain, the model assumes that a given flow profile is prescribed at the inlet, that flow is conserved and pressure is continuous across vessel junctions, and that it incorporates a multiscale boundary condition (a three element Windkessel model) at each outlet. This outlet boundary condition allows prediction of the overall impact on the flow and pressure generated by the downstream vasculature. The coupled fluid structure interaction model is solved using a finite element method that is adapted to account for time history of the viscoelastic model. Results of this study demonstrate that incorporation of a viscoelastic wall model allows more physiologic prediction of arterial blood pressure and vessel deformation, which often is overestimated with the simple elastic wall models, while blood flow does not differ significantly between models.
    No preview · Article · Jan 2011 · SIAM Journal on Applied Mathematics
  • D Valdez-Jasso · D Bia · M A Haider · Y Zocalo · R L Armentano · M S Olufsen
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    ABSTRACT: This study uses linear and nonlinear viscoelastic models to describe the dynamic distention of the aorta induced by time-varying arterial blood pressure. We employ an inverse mathematical modeling approach on a four-parameter (linear) Kelvin viscoelastic model and two five-parameter nonlinear viscoelastic models (arctangent and sigmoid) to infer vascular biomechanical properties under in vivo and ex vivo experimental conditions in ten and eleven male Merino sheep, respectively. We used the Akaike Information Criterion (AIC) as a goodness-of-fit measure. Results show that under both experimental conditions, the nonlinear models generally outperform the linear Kelvin model, as judged by the AIC. Furthermore, the sigmoid nonlinear viscoelastic model consistently achieves the lowest AIC and also matches the zero-stress vessel radii measured ex vivo. Based on these observations, we conclude that the sigmoid nonlinear viscoelastic model best describes the biomechanical properties of ovine large arteries under both experimental conditions considered in this study.
    No preview · Article · Aug 2010 · Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
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    ABSTRACT: Generation of a complete map of arterial wall mechanical properties can improve treatment of cardiovascular diseases via contributions to design of patient specific vascular substitutes used to alleviate atherosclerosis and stenoses, which are predominant in arterial pathways (i.e., abdominal aorta, carotids, or femoral arteries). Clinically useful estimation of arterial properties from patient data requires both efficient algorithms and models that are both complex enough to capture clinically important properties and simple enough to allow rapid computation. In this study, we used mechanical models accounting for both elastic and viscoelastic wall deformation to analyze how vessel properties and associated model parameters vary with artery type. It is known that for the aorta wall, deformation is dominated by nonlinear elastic dynamics, while for the smaller vessels (e.g. the carotid artery) deformation is dominated by viscoelastic responses. The latter is correlated with composition of the vessels; the aorta contains significantly less smooth muscle cells (∼40%) than the carotid artery (∼60%), and has significantly more elastin (see Fig 1).
    No preview · Conference Paper · Jun 2009
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    ABSTRACT: This paper compares two models predicting elastic and viscoelastic prop-erties of large arteries. Models compared include a Kelvin (standard linear) model and an extended 2-term exponential linear viscoelastic model. Models were vali-dated against in-vitro data from the ovine thoracic descending aorta and the carotid artery. Measurements of blood pressure data were used as an input to predict ves-sel cross-sectional area. Material properties were predicted by estimating a set of model parameters that minimize the difference between computed and measured values of the cross-sectional area. The model comparison was carried out using generalized analysis of variance type statistical tests. For the thoracic descending aorta, results suggest that the extended 2-term exponential model does not improve the ability to predict the observed cross-sectional area data, while for the carotid artery the extended model does statistically provide an improved fit to the data. This is in agreement with the fact that the aorta displays more complex nonlinear viscoelastic dynamics, while the stiffer carotid artery mainly displays simpler linear viscoelastic dynamics.
    Full-text · Article · Apr 2009 · Advances in Applied Mathematics and Mechanics
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    ABSTRACT: In this paper, we analyze how elastic and viscoelastic properties differ across seven locations along the large arteries in 11 sheep. We employ a two-parameter elastic model and a four-parameter Kelvin viscoelastic model to analyze experimental measurements of vessel diameter and blood pressure obtained in vitro at conditions mimicking in vivo dynamics. Elastic and viscoelastic wall properties were assessed via solutions to the associated inverse problem. We use sensitivity analysis to rank the model parameters from the most to the least sensitive, as well as to compute standard errors and confidence intervals. Results reveal that elastic properties in both models (including Young's modulus and the viscoelastic relaxation parameters) vary across locations (smaller arteries are stiffer than larger arteries). We also show that for all locations, the inclusion of viscoelastic behavior is important to capture pressure-area dynamics.
    Full-text · Article · Mar 2009 · IEEE transactions on bio-medical engineering
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    D Valdez-Jasso · M A Haider · H T Banks · D Bia · Y Zocalo · R Armentano · M S Olufsen
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    ABSTRACT: The mechanics of the arterial wall is complex, due to its material structure and load conditions, which influence the hemodynamic properties as well as the growth and remodeling process of the cardiovascular system. Arterial remodeling can be found both locally and globally. Local remodeling is typically a result of disease, while global remodeling can be found even for healthy arteries. In this study we have analyzed how elastic and viscoelastic properties differ across 7 locations along the large ovine arteries in 11 sheep. We combined the Kelvin model with experimental measurements of vessel diameter and pressure obtained in-vitro at conditions mimicking the in-vivo dynamics. Elastic and viscoelastic wall-properties were assessed by analyzing values of four model parameters across the 7 locations. To do so we solved an inverse problem, resulting in computed estimates for each of the four parameter values that minimize the residual between the data and the model. We used sensitivity analysis to compute standard errors, and confidence intervals for all model parameters. Results showed that while elastic properties including Young's modulus and the vessel wall thickness varied across locations (smaller arteries were stiffer than larger arteries) viscoelastic relaxation parameters did not differ significantly across locations. We also showed that for all locations, the inclusion of viscoelastic behavior, e.g., using the Kelvin model, is important to capture pressure-area dynamics.
    Full-text · Article · Apr 2007

Publication Stats

90 Citations
15.86 Total Impact Points

Institutions

  • 2014
    • University of Illinois at Chicago
      • Department of Bioengineering
      Chicago, Illinois, United States
  • 2011-2012
    • University of Pittsburgh
      • Bioengineering
      Pittsburgh, Pennsylvania, United States
  • 2009-2011
    • North Carolina State University
      • Department of Mathematics
      Raleigh, North Carolina, United States