Chang Shing Lin

National Sun Yat-sen University, Kao-hsiung-shih, Kaohsiung, Taiwan

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Publications (2)5.95 Total impact

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    ABSTRACT: Over the decade, miRNAs are a most important molecule for the biopharmaceutical industry due to their relation with several human diseases. Presently, the phase-II clinical trial has initiated for the first miRNA-based therapeutics ("Miravirsen") for the treatment of HCV infection. It has been expected that many more miRNA-based therapeutics will enter in the clinical trials. Therefore, it is important to develop different kinds of a novel delivery system with better efficacy, more efficient and less side effects. In this review, we have discussed the various types of miRNAs delivery systems such as viral vectors, lipid-based systems, nano-carriers, LNA-customized DNA delivery without any delivery system. Current status, technical support and the future challenges for miRNA-based delivery have been also discussed.
    No preview · Article · Jan 2016 · Current Drug Metabolism
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    ABSTRACT: In last few years, the use of zebrafish (Danio rerio) in scientific research is growing very rapidly. Initially, it was a popular as a model of vertebrate development because zebrafish embryos are transparent and also develop rapidly. Presently, the research using zebrafish is expanding into other areas such as pharmacology, clinical research as a diseases model and interestingly in drug discovery. The use of zebrafish in pharmaceutical research and discovery and drug development is mainly screening of lead compounds, target identification, target validation, morpholino oligonucleotide screens, assay development for drug discovery, physiology based drug discovery, quantitative structure-activity relationship (QSAR) and structure -activity relationships (SAR) study and drug toxicity study. In this paper, we have described properly all the areas of dug discovery where zebrafish is used as a tool. We are hopeful that the use of these techniques or methods will make the zebrafish a prominent model in drug discovery and development research in the forthcoming years.
    Full-text · Article · Mar 2009 · Current Drug Metabolism