Andrea Lopes

University of Massachusetts Medical School, Worcester, Massachusetts, United States

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Publications (1)32.24 Total impact

  • Source
    Dongning Pan · Masaki Fujimoto · Andrea Lopes · Yong-Xu Wang
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    ABSTRACT: Brown fat is specialized for energy expenditure, a process that is principally controlled by the transcriptional coactivator PGC-1alpha. Here, we describe a molecular network important for PGC-1alpha function and brown fat metabolism. We find that twist-1 is selectively expressed in adipose tissue, interacts with PGC-1alpha, and is recruited to the promoters of PGC-1alpha's target genes to suppress mitochondrial metabolism and uncoupling. In vivo, transgenic mice expressing twist-1 in the adipose tissue are prone to high-fat-diet-induced obesity, whereas twist-1 heterozygous knockout mice are obesity resistant. These phenotypes are attributed to their altered mitochondrial metabolism in the brown fat. Interestingly, the nuclear receptor PPARdelta not only mediates the actions of PGC-1alpha but also regulates twist-1 expression, suggesting a negative-feedback regulatory mechanism. These findings reveal an unexpected physiological role for twist-1 in the maintenance of energy homeostasis and have important implications for understanding metabolic control and metabolic diseases.
    Preview · Article · May 2009 · Cell

Publication Stats

101 Citations
32.24 Total Impact Points

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  • 2009
    • University of Massachusetts Medical School
      • Program in Molecular Medicine
      Worcester, Massachusetts, United States