[Show abstract][Hide abstract] ABSTRACT: Emerging data suggest that pregnancy conveys high risk for severe complications from the 2009 pandemic influenza A virus (2009 H1N1) infection.
We describe an infected pregnant woman with critical illness owing to acute respiratory distress syndrome despite previous vaccination. Early serologic testing indicated absent immunity, followed 11 days later by a robust immune response. The patient required mechanical ventilation for 11 days, but ultimately improved, and was discharged home on hospital day 14.
With the expectation that 2009 H1N1 will continue to cause disease in the immediate future, the virus has been included as a component of the 2010-2011 seasonal influenza vaccine. Vaccination of pregnant women is strongly encouraged. However, regardless of vaccination history, clinicians should remain vigilant for 2009 H1N1 infection when the virus is in circulation, and should not delay antiviral treatment of pregnant women with suspected influenza.
No preview · Article · Feb 2011 · Obstetrics and Gynecology
[Show abstract][Hide abstract] ABSTRACT: Human metapneumovirus (hMPV), a recently discovered paramyxovirus, is thought to be primarily a winter-spring pathogen affecting
young children with a clinical presentation similar to that of respiratory syncytial virus. In June–July 2006, a respiratory
outbreak in a long-term-care facility was reported to the local health department and investigated. Surveillance identified
26 residents and 13 staff with acute respiratory illness; 8 residents (31%) developed radiographically confirmed pneumonia,
and 2 (5%) were hospitalized. Five of 14 respiratory specimens were positive by polymerase chain reaction assay for hMPV;
sequencing identified genotype A. In institutionalized elderly persons, hMPV may be an important cause of respiratory outbreaks
Full-text · Article · Oct 2007 · The Journal of Infectious Diseases