Publications (2)4.3 Total impact
Conference Paper: Effect of Incorporation of an Antimicrobial Monomer on Acrylic Resin[Show abstract] [Hide abstract]
ABSTRACT: Polymethyl methacrylate (PMMA) resins have commonly been used as a denture base material. However, denture bases may act as a reservoir for microorganisms and contribute to oral diseases in denture wearers. It is hypothesized that the 2-tert-butylaminoethyl methacrylate (TBAEMA) incorporated to acrylic resins should have antimicrobial activity related to the presence of amino groups on acrylic resin surface. Objectives: The objectives of this study were to evaluate the presence of amino groups on acrylic resin surface and the influence on flexural strength after incorporation of TBAEMA. Methods: Six groups were divided according to the concentration of TBAEMA incorporated to acrylic resin (Lucitone 550): 0%, 0.5%, 1.0%, 1.5%, 1.75% and 2%. Specimens surface were evaluated by Electron Spectroscopy for Chemical Analysis (ESCA) to detect the presence of amino groups, represented by nitrogen ratios. Flexural strength of the specimens was tested and results were analyzed by ANOVA/Tukey's test (a=.05). Results: Different nitrogen ratios were observed on specimen surfaces: 0%, 0.13%, 0.74%, 0.66%, 0.92% and 0.33% for groups 0, 0.5, 1.0, 1.5, 1.75, and 2%, respectively. Significant differences were found for flexural strength (p<0.001). The mean flexural strength values were 98.33.9A, 93.33.2A, 83.92.1B, 82.85.2B, 71.25.1C and 17.33.2D MPa for groups 0, 0.5, 1.0, 1.5, 1.75, and 2%, respectively. Same capital letters indicate no significant difference detected by the post hoc tests. Conclusion: Within the limitations of this study, the presence of amino groups on specimen surfaces after the incorporation of TBAEMA into acrylic resin could indicate possibility of antimicrobial activity, but may affect the flexural strength, depending on the concentration of TBAEMA.
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ABSTRACT: Research has clarified the properties required for polymers that resist bacterial colonisation for use in medical devices. The increase in antibiotic-resistant microorganisms has prompted interest in the use of silver as an antimicrobial agent. Silver-based polymers can protect the inner and outer surfaces of devices against the attachment of microorganisms. Thus, this review focuses on the mechanisms of various silver forms as antimicrobial agents against different microorganisms and biofilms as well as the dissociation of silver ions and the resulting reduction in antimicrobial efficacy for medical devices. This work suggests that the characteristics of released silver ions depend on the nature of the silver antimicrobial used and the polymer matrix. In addition, the elementary silver, silver zeolite and silver nanoparticles, used in polymers or as coatings could be used as antimicrobial biomaterials for a variety of promising applications.