[Show abstract][Hide abstract] ABSTRACT: Splenic lymphoma with villous lymphocytes (SLVL) is a low grade lymphoproliferation characterized by a massive splenomegaly, an absence of lymphadenopathy and the presence in the peripheral blood of atypical B-lymphocytes with hairy-cell appearance. We have studied the morphological, immunological and molecular characteristics of 3 cases of SLVL. SLVL presented on blood smears characteristic irregularities of the plasma membrane consisting in thin and short villi unevenly distributed. The main phenotype was CD5-, CD11c+, and CD25-, but individual SLVL cases can not be identified by using immunohistochemical criteria alone. Clonal rearrangements of the immunoglobulin heavy chain gene were found in all 3 cases and in one case presented a bcl2-JH rearrangement. SLVL are clonal B-cell lymphoproliferations and can be associated with t(14; 18) translocation.
No preview · Article · Oct 1996 · Annales de Pathologie
[Show abstract][Hide abstract] ABSTRACT: Authors report a new case of cutaneous alternariosis in a 73-year-old man submitted to a long term corticotherapy. Direct microscopic examination of pus taken from pustule and histological study of biopsies reveal hyphae and round-shaped fungal cells. Alternaria chlamydospora is isolated from biopsy samples on culture. This observation is the first French case of cutaneous alternariosis caused by A. chlamydospora.