Wenhui Cai

Wayne State University, Detroit, Michigan, United States

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Publications (3)5.43 Total impact

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    ABSTRACT: Immunocytochemical localization was carried out for five isoforms of protein kinase C (PKC) in the cat retina. In common with other mammalian species, PKCalpha was found in rod bipolar cells. Staining was also seen in a small population of cone bipolar cells with axon terminals ramifying near the middle of the inner plexiform layer (IPL). PKCbetaI was localized to rod bipolar cells, one class of cone bipolar cell, and numerous amacrine and displaced amacrine cells. Staining for PKCbetaI was seen in three types of cone bipolar cells as well as in amacrine and ganglion cells. Immunoreactivity for both PKCepsilon and PKCzeta was found in rod bipolar cells; PKCepsilon was also seen in a population of cone bipolar cells and a few amacrine and ganglion cells whereas PKCzeta was found in all ganglion cells. Double-label immunofluorescence studies showed that dendrites of the two PKCbetaII-positive OFF-cone bipolar cells exhibit immmunoreactivity for the kainate-selective glutamate receptor GluR5. The third PKCbetaII cone bipolar is an ON-type cell and did not stain for GluR5. The retinal distribution of these isoforms of PKC is consistent with a role in modulation of various aspects of neurotransmission including synaptic vesicle release and regulation of receptor molecules.
    No preview · Article · Sep 2002 · Visual Neuroscience
  • Wenhui Cai · Roberta G. Pourcho
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    ABSTRACT: The distribution of metabotropic glutamate receptors 1α (mGluR1α) and mGluR2/3 in the cat retina was studied through the use of preembedding immunocytochemistry for light and electron microscopy. Staining for mGluR1α in the outer plexiform layer was seen in numerous punctate structures that were identified as rod spherules. Cone pedicles remained unlabeled. A number of amacrine and ganglion cell somata also were stained with processes ramifying throughout the inner plexiform layer. These processes were postsynaptic to cone bipolar cells in both sublaminae, where they comprised one but not both of the postsynaptic elements at dyad contacts. Immunostaining for mGluR2/3 was observed in horizontal cells as well as in numerous amacrine and displaced amacrine cells. Labeled amacrine processes were postsynaptic to cone bipolar cells in both sublaminae but, similar to mGluR1α, comprised only one of the postsynaptic elements. Staining for mGluR2/3 also was seen in amacrine processes postsynaptic to rod bipolar terminals; these processes were identified as belonging to type A17 amacrine cells. The distribution patterns indicate that both mGluR1α and mGluR2/3 are positioned for postsynaptic function, whereas mGluR1α also may contribute to the presynaptic regulation of glutamate release from rod photoreceptors. J. Comp. Neurol. 407:427–437, 1999. © 1999 Wiley-Liss, Inc.
    No preview · Article · May 1999 · The Journal of Comparative Neurology
  • Wenhui Cai · Roberta G. Pourcho

    No preview · Article · Jan 1999

Publication Stats

49 Citations
5.43 Total Impact Points


  • 1999
    • Wayne State University
      • Department of Anatomy and Cell Biology
      Detroit, Michigan, United States