[Show abstract][Hide abstract] ABSTRACT: To compare two propofol infusion techniques in bitches subjected to ovary histerectomy by estimating the efficiency of the propofol target-dose, evaluating the cardiorespiratory and hemogasimetric attributes, and the bispectral scale index (BIS) as well as the recovery period characteristics.
Twenty anesthetized bitches were divided into two groups of 10 each (G1, G2). Animals of G1 were pre-treated with methotrimeprazine and anesthetized with target-controlled propofol infusion by means of a Harvard infusion pump combined to remifentanil through a syringe pump.
Bradycardia and light hypotension, hemogasimetric and respiratory stability besides a good myorelaxation, more evident during continuous infusion and good hypnosis.
Dosis used in both techniques, after methotrimeprazine pre-treatment and combined to the opioid, were efficient for the surgery. The target-controlled anesthesia required a smaller anesthetic consumption (propofol) with faster recovery periods.
Preview · Article · Feb 2008 · Acta Cirurgica Brasileira
[Show abstract][Hide abstract] ABSTRACT: To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine, ketamine and midazolam, the degree of hypnosis, myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality.
20 healthy adult females dogs, aged 3 to 5 years, body weight between 7 and 15 kg, were assigned randomly and homogenously to 2 groups of 10 animals each (n=10), group 1 (G1) and group 2 (G2), respectively. Animals of G1 were subjected to a pre-treatment with intravenous 1.0 mg/kg methotrimeprazine and or 3ì/kg. After 15 minutes, a 5.0 mg/kg ketamine and 0.2 mg/kg midazolam were intravenously injected. Immediately after induction, an anesthetic combination of 0.4 mg/kg/h midazolam, 20 mg/kg/h ketamine and 1.0 mg/kg/h xylazine, was continuously and intravenously administered for 30 minutes. The same techniques were used in G2 except for the substitution of xylazine for 30ìg/kg/h medetomidine.
In G1 there was a 1st and 2nd degree atrioventricular heart block, a longer recovery period and lower quality. In G2 a 1st degree atrioventricular heart block occurred but isolated and ephemeral.
The continuous infusion method, besides reducing drugs utilization, prevented collateral effects allowing a more tranquil recovery with no excitations, both protocols permitted the surgical procedure (ovary-hysterectomy) bringing about a reduction in hypnosis and an accentuated myorelaxation. Xylazine and medetomidine showed a similar pharmacodynamic behavior but with different clinical aspects. The electrocardiographic alterations observed in G2 and in a lower degree in G1 must be well studied. Describers: dogs, ketamine, methotrimeprazine, medetomidine, midazolam and xylazine.
Preview · Article · Aug 2007 · Acta Cirurgica Brasileira
[Show abstract][Hide abstract] ABSTRACT: To investigate the effect of bovine bone morphogenetic proteins (bBMPs) bound to hydroxyapatite plus collagen in the healing of unstable radius fractures.
A transverse fracture was induced at the mid of the diaphysis in both radii on 15 Norfolk rabbits with average age of 5.5 months and 3.5 kg. A mixture of bBMPs bound to thin powdered hydroxyapatite (bBMP-HA) and bovine collagen as agglutinant was applied to the right radius fracture site. The left radius fracture was considered control and no treatment was used. After 30, 60 and 90 days (5 rabbits/period) the rabbits were euthanized and the radii were collected for histological analysis.
The descriptive histological analysis revealed that repair was similar for both forelimbs. The histomorphometric analysis showed that the mean area of newly formed bone was 867442.16 mm2, 938743.00 mm2 and 779621.06 mm2 for the control forelimbs, and 841118.47 mm2, 788038.76 mm2 and 618587.24 mm2 for the treated forelimbs at 30, 60 and 90 days, respectively. Thus the newly formed bone area was 12.17% larger in the forelimbs treated with bBMP-HA/collagen than in the control forelimbs (p<0.05, Tukey test) in the 60-day period after surgery. In both forelimbs the newly formed bone area increased throughout the experimental period until the complete fracture healing.
Based on the result obtained here we concluded that bBMP-HA/collagen induced a lower but significant improvement in fracture consolidation.
[Show abstract][Hide abstract] ABSTRACT: The aim of this study was to evaluate the barrier capacity of the bovine demineralized lyophilized bone cortical membrane, testing its permeability and its integrity in association with lyophilized bovine pericardium membrane. Fifteen male adult Wistar rats were used. The combination of two bone cortical membranes with bovine pericardium membrane inside was implanted subcutaneously in the cervical-thoracic area. The animals (five rats per group) were submitted to euthanasia at 15, 30 and 60 days postoperatively. On day 15 postoperative, the microscopic evaluation showed integrity of the membranes, except the absorption of small areas of the bone cortical membrane in the sites of nutritive channels. On day 30, there was a remnant of bone cortical membrane, and on day 60 bone cortical membrane was completely absent. It was possible to conclude that bovine demineralized lyophilized bone cortical membrane is quickly absorbed and does not preserve the lyophilized bovine pericardium membrane.
[Show abstract][Hide abstract] ABSTRACT: The aim of this study was to evaluate by radiographic and densitometric examinations the influence of a biomaterial developed by the Brazilian industry in the reparation process of unstable diaphyseal fracture of the radius. Fifteen Norfolk rabbits, males, age between five and six months, and average body weight of 3.5 kg were used. A transversal fracture was induced in the middle portion of the radial diaphysis of both forelimbs using a circular saw. The association of BMPs adsorbed to the hydroxiapatite and agglutinant of collagen in granules, both of bovine origin, were used around the fracture extremities of the right radius (treated). The left radius did not receive any treatment, and it was considered as control. Radiographic evaluation and optic densitometry by radiographic examinations were realized at immediate postoperative, and at 30, 60 and 90 days postoperative. Only at 30 days postoperative occurred higher percentage of cortical reestablishment of the fracture treated with biomaterial. By statistical analysis was not observed any difference in densitometric examinations in the different evaluation moments or between forelimbs. It was possible to conclude that only radiographic examination on day-30 postoperative was observed positive effect of the biomaterial.
Full-text · Article · Nov 2004 · Brazilian Journal of Veterinary Research and Animal Science