C Janaki

Madras Medical College, Chennai, Tamil Nadu, India

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Publications (39)22.74 Total impact

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    ABSTRACT: BACKGROUND: Sertaconazole is a new, broad spectrum, fungicidal and fungistatic imidazole with added antipruritic and anti-inflammatory activity that would provide greater symptomatic relief and hence would be beneficial in improving the quality of life for the patient with dermatophytoses. AIMS AND OBJECTIVES: To compare efficacy and safety of sertaconazole, terbinafine and luliconazole in patients with dermatophytoses. MATERIALS AND METHODS: 83 patients with tinea corporis and tinea cruris infections were enrolled in this multicentre, randomized, open label parallel study. The initial 'Treatment Phase' involved three groups receiving either sertaconazole 2% cream applied topically twice daily for four weeks, terbinafine 1% cream once daily for two weeks, luliconazole 1% cream once daily for two weeks. At the end of treatment phase, there was a 'Follow-up Phase' at end of 2 weeks, where the patients were assessed clinically and mycologically for relapse. RESULTS: Of the 83 patients, 62 completed the study, sertaconazole (n = 20), terbinafine (n = 22) and luliconazole (n = 20). The primary efficacy variables including change in pruritus, erythema, vesicle, desquamation and mycological cure were significantly improved in all the three groups, as compared to baseline, in the Treatment and Follow-up phase. Greater proportion of patients in sertaconazole group (85%) showed resolution of pruritus as compared to terbinafine (54.6%); and luliconazole (70%), (P < 0.05 sertaconazole vs terbinafine). There was a greater reduction in mean total composite score (pruritus, erythema, vesicle and desquamation) in sertaconazole group (97.1%) as compared to terbinafine (91.2%) and luliconazole (92.9%). All groups showed equal negative mycological assessment without any relapses. All three study drugs were well tolerated. Only one patient in sertaconazole group withdrew from the study due to suspected allergic contact dermatitis. CONCLUSION: Sertaconazole was better than terbinafine and luliconazole in relieving signs and symptoms during study and follow up period. At the end of 'Treatment Phase' and 'Follow-up' Phase, all patients showed negative mycological assessment in all three treatment groups suggesting no recurrence of the disease.
    No preview · Article · Feb 2013 · Indian Journal of Dermatology
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    ABSTRACT: Epithelioid hemangioendothelioma is an intermediate-grade vascular tumor arising from the vascular endothelium, which usually arises in soft tissue, and skin involvement is extremely rare. We report a case that presented with primary cutaneous tumor involving the whole limb and was present since birth.
    No preview · Article · Jan 2012 · Indian Journal of Dermatology
  • Anupama S Roshan · C Janaki · B Parveen
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    ABSTRACT: White Piedra is a superficial fungal infection of the hair caused by Trichosporon asahii. It is also known as trichomycosis nodosa or trichomycosis nodularis. We report two cases of White Piedra in a mother and her daughter for the rarity of such occurrence.
    No preview · Article · Jul 2009 · International Journal of Trichology
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    ABSTRACT: Hair infection by fungal agents, also called trichomycoses, is one of the common concerns in human beings. The common agents causing hair infections are dermatophytes, Malassezia species and those causing piedra. The former two can give rise to considerable discomfort and also cause immune-mediated reactions in the form of kerion and dermatophytids. The etiopathogenesis of trichomycoses, along with its clinical aspects and the management, are briefed here.
    No preview · Article · Jul 2009 · International Journal of Trichology
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    ABSTRACT: Hyper IgE syndrome (HIES) is a rare immunodeficiency syndrome characterized by a triad of cutaneous abscesses, mostly caused by Staphylococus aureus; pneumonia; and raised IgE levels. Nonimmunological associations include course facial features, multiple bone fractures, joint hyperextensibility, and retained primary dentition. Patients require long-term antibiotic therapy. We report here a classical case of HIES with rare associations of natal teeth, bilateral cervical ribs, and conductive deafness. The patient was being treated with monteleukast and dapsone.
    No preview · Article · Apr 2009 · Indian Journal of Dermatology
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    ABSTRACT: An unusual case of rhinocerebral zygomycosis with its clinical and histopathological features are presented. A good response was observed with oral itraconazole at a dose of 200 mg day-1 for a period of 3 months. To our knowledge, it is the first case report of this infection, involving the maxillary sinus, eye and the brain, from Madras, Tamilnadu, India. Zusammenfassung. Es wird ein ungewöhnlicher Fall einer rhinozerebralen Zygomykose in seinem klinischem und histopathologischem Bild vorgestellt. Mit Itraconazol oral 200 mg pro Tag über drei Monate hinweg wurde ein guter Heilungserfolg erzielt. Dies dürfte der erste Fall dieses Mykosetyps mit Kieferhöhlen-, Augen- und Gehirnbeteiligung sein, der aus Madras, Tamilnadu, Indien, berichtet wird.
    No preview · Article · Jan 2009 · Mycoses
  • P Kannan · C Janaki · G S Selvi
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    ABSTRACT: The common cause of skin infections are dermatophytes and opportunistic fungi. Aim of this study was to isolate and identify the fungal agents from clinical samples from patients with different mycoses. Clinical samples from 165 patients were subjected to potassium hydroxide (KOH) examination and culture isolation; causative agents were identified macroscopically and microscopically. All the 165 specimens were KOH positive and 110/165 (66.7%) samples were culture positive. Of these, highest isolation rate was obtained in opportunistic mycoses such as candidiasis (29/29, 100%). Dermatophytes were isolated in 53/80 (66.3%) specimens and Trichophyton rubrum was the commonest isolate in skin samples (17/24) among the patients suffering from dermatophytosis. Phaeoannellomyces wernecki was isolated in a patient suffering from tinea nigra. The study signifies the importance of mycological examination in the diagnosis of various mycoses for their effective management.
    No preview · Article · Aug 2006 · Indian Journal of Medical Microbiology
  • Anupama Roshan · CR Janaki · GS Selvi · B Parveen · N Gomathy
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    ABSTRACT: Disseminated cryptococcosis is one of the acquired immune deficiency syndrome defining criteria and the most common cause of life threatening meningitis. Disseminated lesions in the skin manifest as papules or nodules that mimic molluscum contagiosum (MC). We report here a human immunodeficiency virus positive patient who presented with MC like lesions. Disseminated cryptococcosis was confirmed by India ink preparation and histopathology. The condition of the patient improved with amphotercin B.
    No preview · Article · Jul 2006 · Indian Journal of Dermatology
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    Kannan P · Janaki C · Selvi GS
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    ABSTRACT: The common cause of skin infections are dermatophytes and opportunistic fungi. Aim of this study was to isolate and identify the fungal agents from clinical samples from patients with different mycoses. Clinical samples from 165 patients were subjected to potassium hydroxide (KOH) examination and culture isolation; causative agents were identified macroscopically and microscopically. All the 165 specimens were KOH positive and 110/165 (66.7%) samples were culture positive. Of these, highest isolation rate was obtained in opportunistic mycoses such as candidiasis (29/29, 100%). Dermatophytes were isolated in 53/80 (66.3%) specimens and Trichophyton rubrum was the commonest isolate in skin samples (17/24) among the patients suffering from dermatophytosis. Phaeoannellomyces wernecki was isolated in a patient suffering from tinea nigra. The study signifies the importance of mycological examination in the diagnosis of various mycoses for their effective management.
    Preview · Article · Jan 2006
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    ABSTRACT: A case of hyper-IgE syndrome in a 6 year old boy with bronchial asthma is reported here with the various manifestations of multiple tender abscesses of the scalp, recurrent dermatophyte infections of his face and right thigh, eczematous lesions of his neck, shoulders and antecubital fossae, candidiasis of the tongue, angular cheilitis and total dystrophy of his right bit toe nail. Laboratory investigations revealed staphylococcus aureus infection of the scalp, Trichophyton rubrum infection of the face and the thigh and candidal onychomycosis. Immunological survey revealed markedly elevated serum lgE level.
    No preview · Article · Jan 2004
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    ABSTRACT: Actinomycotic mycetoma of the anterior abdominal wall with inguinal lymphnode involvement, an exceedingly rare entity is described here with mycological histological features. Remarkable therapeutic response was noted with Welsh regimen.
    No preview · Article · Jan 2004
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    ABSTRACT: Cryptococcosis is one the emerging mycoses, given the context of the ongoing human immunodeficiency virus (HIV) pandemic. Disseminated cutanous cryptococcosis with obvious involvement of the central nervous system is described here, with the aim of emphasizing the importance of histopathological examination in the diagnosis of HIV related dermatoses and to highlight the fact that cutaneous cryptococcsis may be a harbinger of neurological involvement.
    No preview · Article · Jan 2004
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    ABSTRACT: An 11 year old female child had a small painful spot over the scalp of 4 months duration. Earlier, she had undergone a local excision for a similar problem, but it had recurred at the same site after a few months. Examination revealed a skin colored sessile tender firm papule of 3 mm size on the right parietal region. Excision biopsy showed broad fascicles of tumor cells with eosinopilic cytoplasmic granules infiltrating the dermis amongst the collagen bundles, which was consistent with granular cell schwannoma.
    No preview · Article · Jan 2004
  • I Bhat · C Janaki · G Sentamilselvi · V R Janaki
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    ABSTRACT: A 54-year-old man, a road layer by occupation, presented with a 'leonine facies' and multiple tumors that were more commonly present over the exposed parts of the body. On investigation, he turned out to be a case of primary cutaneous B cell lymphoma with a distinctive histopathology. Chemotherapy was given with a good therapeutic response.
    No preview · Article · Jul 2003 · Indian journal of dermatology, venereology and leprology
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    ABSTRACT: Treatment of mycetoma is always considered a challenge to the dermatologists. Hence this study was undertaken to determine the efficacy of various therapeutic regimens in actinomycotic and eumycotic mycetoma. A total of 25 patients including 18 cases of actinomycotic mycetoma and 7 cases of eumycotic mycetoma was included. Combinations of trimethoprim-sulfamethoxazole (TS) with rifampicin (regimen-3), and TS monotherapy (regimen-4) were used in 9,2,1 and 6 patients with actinomycotic mycetoma respectively. Ketoconazole (regimen-A) and itraconazole (regimen-B) were used in patients with eumycotic mycetoma along with surgical excision (in amenable cases). Remission was observed in 10 cases of actinomycotic mycetoma (eight with Welsh regimen) and one case of eumycetoma who was subjected to surgical excision followed by oral ketoconazole. Improvement was seen in 2 cases of actinomycetoma treated one each with Welsh regimen and regimen4: in 2 cases of eumycetoma treated with ketoconazole in one and itraconazole in the other. No significant adverse effect was noted in the study except ototoxicity and reaction to streptomycin in one patient. In general, therapeutic outcome was excellent in patients with actinomycotic mycetoma particularly with Welsh regimen, whereas the response to medical therapy in eumycetoma is not satisfactory. Complete surgical excision followed by antifungal therapy at an early stage for eumycotic mycetoma is perhaps the best possible therapeutic modality in the present scenario.
    No preview · Article · Jan 2003
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    ABSTRACT: A case of asymptomatic multiple leiomyoma along with its histopathological features is described.
    No preview · Article · Jul 2002 · Indian journal of dermatology, venereology and leprology
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    ABSTRACT: A case of angiolymphoid hyperplasia with eosinophilia is reported here with clinical and pathological features.
    No preview · Article · Jan 2002

  • No preview · Article · Jan 2001
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    ABSTRACT: A new entity named as tropical eczema has been described in patients uniquely presenting with pruritic, papulovesicular rash in summer months, the majority of whom was female in the middle age group. Morphologically, the lesions varied from erythermatous, moist, excoriated papules and papulovesicular dry, scaly, flattened papules and patches which chiefly involved the flexural areas, though others like arms, thighs and trunk were also additionally involved in many patients. Though the clinical picture resembled Grover’s disease (transient acantholytic dermatosis) in many aspects, the age group, the sex and the sites of chronic dermatitis with no evidence of acantholysis or dyskeratosis. Hence, this dermatosis has been labeled as “TROPICAL ECZEMA” for its occurrence in tropical climate with classical eczematous histology.
    No preview · Article · Jan 2000
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    ABSTRACT: The clinical efficacy and safety of once daily topical administration of 1% oxiconazole cream and lotion was assessed in an open label, non comparative trial in tinea cruris, tinea corporis and tinea pedis patients. In treated patients, severity scores of erythema, pruritus, scaling, vesicles, papules and burning showed a progressive fall over a period of 4 weeks at all the study centres. With lotion, mean percentage improvement of symptoms varied from 35% (week 1) to 87.6 - 98.7% (week 4). With cream, it varied from 35% (week 1) to 82.5 - 99.5% (week 4). Overall global evaluation response showed clear, excellent and good response in 60%, 21% and 17% of the patients treated with lotion respectively. With cream, excellent and good response was observed in 71%, 10% and 16% of the patients respectively. In T. pedis patients, clear, excellent and good response was observed in 4/8, 2/8 and 1/8 patients respectively with lotion. Cream showed clear (8/15), excellent (4/15) and good (1/15) in these patients. None of the patients out of 178 enrolled, reported any side effect during the trial.
    No preview · Article · Jan 2000 · Indian Journal of Dermatology Venereology and Leprology

Publication Stats

216 Citations
22.74 Total Impact Points

Institutions

  • 1997-2013
    • Madras Medical College
      • Department of Dermatology
      Chennai, Tamil Nadu, India