Md. Arifuzzaman's scientific contributions
Publications (2)
- Abstract: The rural and marginal people of Bangladesh are deprived of modern treatment facilities and hence greatly depend on medicinal plants. Besides, the higher cost and toxicity of synthetic drugs drives scientists towards search for natural source of medication for a number of diseases. Cost-effectiveness, easy availability and fewer side effects are making the herbal medicine more popular both among rural and city people. Plants with Cytotoxic and clot lysis potential are good candidate as... Show More
- Abstract: In recent years, bacterial infections are increasing due to emergence of antibiotic resistance. Oxidative stress and gall bladder stones also pose a great health threat to millions. This study attempted the assessment of antibacterial, anti-oxidant and anti-gall bladder stones activity of an important medicinal plant Achyranthes aspera methanolic leaf extract. Anti-bacterial activity was performed by disc diffusion method. Significant susceptibility was observed against gram positive... Show More
Publications citing this author (3)
- In the present study we have demonstrated the optimum culture conditions required for maximum secretion of antibacterial compounds by the endophytic fungal genus JAS-2, which was isolated from Achyranthus aspera, commonly known as latzeera, chichida, apamarga. Considering multiple medicinal properties of this plant such as cytotoxity [6] and wound healing [7], the plant was chosen for isolating biologically active endophytic fungi. Since crude metabolite consists only a meagre amount of bioactive product, it is extremely important to increase the amount of active compound.
[Show abstract] [Hide abstract] ABSTRACT: The present study explores the efficacy of an endophytic fungus from symbiotic plant Achyranthus aspera, an herb of medicinal importance. Considering limitation of secreted fungal metabolites in terms of biologically active molecules; an endeavour was made to increase the amount of secreted active product. Enhanced secretion of active compound was observed by optimizing different parameter of culture conditions. The fungal culture was isolated from stem of Achyranthus aspera and taxonomically identified as Aspergillus terreus. While analysing it's different in vitro potential, culture metabolites showed antibacterial, antifungal and anti-oxidant activity. In order to increase the yield of compound, culture was optimized for different parameters such as carbon and nitrogen sources and extracting solvent. All the optimization was performed based on % inhibition of bacterial growth when challenged with 10 μg/μl metabolite concentration. Among different media used, potato dextrose broth (PDB) and sabouraud's dextrose broth (SDB) proven to be better media for growth of fungus as well as metabolites production. 1% yeast extract and 4% dextrose resulted in higher cell inhibition. Ethyl acetate served as good extracting solvent.
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