M. H. Basar's scientific contributionswhile working at Khulna University (Khulna, Bangladesh) and other institutions
Publications (2)
- Abstract: The mangrove fruit Sonneratia apetala Buch.-Ham. is extensively consumed by the people of coastal Bangladesh especially adjacent to the Sundarbans’ forest. Seeds consist of very high content of polyphenols (300 ± 8.2 mg GAE/g extract), flavonoids (30.6 ± 0.7 CE/g extract), anthocyanins (2.3 ± 0.03 μmol/g extract) and vitamin C (4.0 ± 0.08 mg/g extract). The IC50 values for DPPH and NO free radical scavenging were 4.3 and 49.4 μg/mL for seed extract and that for pericarp extract were 59.8 and... Show More
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Article: A comparative study of antioxidant potential of commonly used antidiabetic plants in Bangladesh
Abstract: Various literatures recorded approximately 60 medicinal plants in Bangladesh that have antidiabetic properties. Of these medicinal plants, only 14–16 are found in traditional herbal markets and they are being randomly used to treat diabetes. Since diabetes mellitus increases reactive free radicals along with various complications in the body, antidiabetic plants that can potentially neutralize free radicals, may be of central interest to manage the disease. Present study compares functional... Show More
Publications citing this author (23)
- S. apetala is a highly adaptable, fast growing plant that acts as a pioneer species in ecological succession in many degenerated mangrove forests (Chen et al., 2003). The fruits of S. apetala are extensively consumed by the coastal people of Bangladesh for antidiabetic, antibacterial and antioxidant capacities (Hossain et al, 2013). Thus, we aimed to study the total phenolic content and free radical scavenging activity related to antioxidant capacity and membrane stabilizing ability of the bark of S. apetala and we, here in, report the results of our preliminary investigations.
[Show abstract] [Hide abstract] ABSTRACT: p>This study was carried out to investigate the antioxidant activity in terms of free radical scavenging capacity and membrane stabilizing ability of methanol extract of bark of Sonneratia apetala . The total phenol content of the extract was measured by Folin-Ciocalteu reagent. The antioxidant potential was investigated using 2,2 diphenylpicrylhydrazyl (DPPH), reducing power assay and chelating power determination. The membrane stabilizing capacity was assessed by monitoring the hypotonic solution - and heat-induced haemolysis of human erythrocytes. The total phenolic content was found 50.75 mg/gm of gallic acid equivalent. The extract exhibited significant antioxidant activity in DPPH free radical scavenging assay with IC<sub>50</sub> value of 81.42 µg/ml as compared to the standard, BHT (IC<sub>50</sub>=42.56 µg/ml), Fe<sup>2+</sup> ion reducing power assay and chelating power ability. In case of assay for chelating ability, EDTA represented 98.76% chelation while the plant extract showed 82.83% at concentration of 100 μg/ml. In addition, the methanol extract of bark of this plant was found to moderately inhibit the haemolysis of human erythrocyte. In conclusion, the methanol extract of S. apetala could be valuable candidate for future development for antioxidant activity. Bangladesh Pharmaceutical Journal 19 (2): 147-151, 2016</p- The chloroform extract of leaves of Acacia salicina was found to possess significant antimutagenic and antioxidant activities against superoxide radicals. The antioxidant property of medicinal plants is associated with the presence of several phytoconstituents such as flavonoids (Hamouz et al., 2011), anthocyanins and phenolics (Basar et al., 2013). A flavonol 3-O-glycosides (Isorhamnetin 3-O-neohesperidoside) isolated from A. salicina leaves protected the cells against oxidative stress by inhibiting xanthine oxidase and superoxide anion scavengers (Bouhlel et al., 2010 ).
[Show abstract] [Hide abstract] ABSTRACT: The present study assessed the comparative antioxidant potential of the ethanol extract (EE) of leaves of four Acacia species (A. salicina, AS; A. laeta, AL; A. hamulosa AH; and A. tortilis, AT) grown in Saudi Arabia, including RP-HPTLC quantification of antioxidant biomarker rutin. In vitro DPPH radical scavenging and β-carotene-linoleic acid bleaching assays showed the promising antioxidant activities of Acacia extracts: ASEE (IC50: 60.39 and 324.65 μg/ml) >ALEE (IC50: 217.06 and 423.36 μg/ml) >ATEE (IC50: 250.13 and 747.50 μg/ml) >AHEE (IC50: 255.83 and 417.28 μg/ml). This was comparable to rutin tested at 500μg/ml. Further, a RP- HPTLC densitometric method was developed (acetonitrile: water; 6:4; v/v) using glass-backed RP-18 silica gel F254 plate, and scanned at UVmax 254 nm. The method was validated as per the ICH guidelines. Analysis of the validated RP-HPTLC displayed an intense peak (Rf = 0.65±0.004) of rutin that was estimated (μg/mg dry weight) to be highest in ASEE (10.42), followed by ALEE (2.67), AHEE (1.36) and ATEE (0.31). Taken together, presence of rutin strongly supported the high antioxidant property of the tested Acacia species, especially A. salicina. The developed RP-HPTLC method therefore, affirms its application in the quality control of commercialized herbal drugs or formulation containing rutin.
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