A.A. Adewuyi

Utrecht University, Utrecht, Utrecht, Netherlands

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Publications (3)4.57 Total impact

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    ABSTRACT: To survive and produce milk, postpartum dairy cows use their reserves through lipolysis. If the negative energy balance is severe, nonesterified fatty acids (NEFA) are formed that can impair several physiological processes. A pilot study suggested that increased walking activity after calving may be related to a reduced serum concentration of NEFA. The objective of this study was to determine the relationship between plasma concentrations of NEFA and walking activity in dairy cattle during the postpartum period. Data were collected from 33 multiparous Holstein-Friesian dairy cows. Walking activities were quantified using pedometry, and blood samples were collected for determination of NEFA. Results of this study indicated that a negative relationship existed between walking activity and plasma NEFA concentrations in postpartum dairy cows.
    No preview · Article · Sep 2006 · Journal of Dairy Science
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    ABSTRACT: The future of acute phase proteins (APPs) in science is discussed in this paper. Many functions and associated pathological processes of APPs are unknown. Extrahepatic formation in local tissues needs attention. Local serum amyloid A (SAA) formation may be involved in deposition of AA-amyloid induced by conformational change of SAA resulting in amyloid formation, having tremendous food safety implications. Amyloidogenesis is enhanced in mouse fed beta pleated sheet-rich proteins. The local amyloid in joints of chicken and mammary corpora amylacea is discussed. Differences in glycosylation of glycoproteins among the APPs, as has been shown for alpha1-acid glycoprotein, have to be considered. More knowledge on the reactivity patterns may lead to implication of APPs in the diagnostics and staging of a disease. Calculation of an index from values of several acute phase variables increases the power of APPs in monitoring unhealthy individuals in animal populations. Vaccinations, just as infections in eliciting acute phase response seem to limit the profitability of vaccines because acute phase reactions are contra-productive in view of muscle anabolism. Interest is focused on amino acid patterns and vitamins in view of dietary nutrition effect on sick and convalescing animals. When inexpensive methodology such as liquid phase methods (nephelometry, turbidimetry) or protein array technology for rapid APP measurement is available, APPs have a future in routine diagnostics. Specific groups of patients may be screened or populations monitored by using APP.
    Full-text · Article · Nov 2005 · Journal of Zhejiang University SCIENCE B
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    A.A. Adewuyi · E Gruys · F.J.C.M. van Eerdenburg
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    ABSTRACT: The objective of this report is to review the literature on elevated blood concentrations of nonesterified fatty acids (NEFA) before and after parturition in high-yielding dairy cows. It highlights the factors that influence serum NEFA production and their circulation before and after parturition, such as adaptation for nutrient partitioning for fetal needs, onset of lactogenesis, stress of calving and numerous changes in physiological, metabolic, and endocrine status to accommodate parturition and lactogenesis. The role of NEFA in the liver and peripheral tissues and its toxic effects when in excess are discussed. The cow's adaptive physiologic mechanisms to prevent or decrease excessive values of serum NEFA and preventive and therapeutic interventions to enhance these mechanisms are categorized as natural and artificial antidotes respectively. Feeding systems during the dry period and daily exercise or walking activity which may burn excessive NEFA through beta-oxidation in the muscles are considered as more useful antidotes to managing the NEFA metabolism. This will minimize accumulation of lipids in the liver during early lactation and alleviate the negative effects of plasma NEFA leading to more optimal metabolic health and productivity of dairy cows.
    Preview · Article · Oct 2005 · The Veterinary quarterly