F.V. Manvi

KLE College of Pharmacy, Belgaum, Karnataka, India

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Publications (69)44.83 Total impact

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    ABSTRACT: Paclitaxel (PTX) is an antineoplastic agent, commonly used to treat some leukemias, Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others. However, expansion of the clinical utility of Paclitaxel has been limited by its liver and cardiac toxicity and myelosuppression. In the present study proliposome drug delivery system for Paclitaxel was developed, which will increase the efficacy and reduce the toxicity. Proliposomal drug delivery system for Paclitaxel was prepared by modified film hydration method using different ratio of two different carriers and same coating polymer with different concentrations. Formulations F1, F2 and F3, F4 were prepared by using Egg phosphatidylglycerol (EPG) and Distearoyl phosphatidylcholine (DSPC) as a carrier respectively and coating polymer PEGylated phospholipid (MPEG 2000-DSPE, Sodium salt). All the formulations were compared in terms of particle size, zeta potential, encapsulation efficiency, in vitro drug release. Optimized formulation F2 was evaluated for pharmacokinetics parameters and stability studies as per ICH guidelines. Stability studies revealed that 4 °C is the most suitable temperature for storage of proliposomal drug delivery system for Paclitaxel.
    No preview · Article · Jun 2013
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    ABSTRACT: Inspite of the well-known antibacterial activity of Prulifloxacin, structural studies of this molecule are not reported. We discuss three new X-ray crystal structures of Prulifloxacin guest free form and its solvates with methyl ethyl ketone and nitromethane. The role of the solvent molecules in altering the crystal packing and hydrogen bonding is discussed. All the novel solid-state forms were characterized by PXRD, DSC and IR techniques.
    Full-text · Article · Jun 2013
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    Full-text · Article · Apr 2013 · Journal of Controlled Release
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    ABSTRACT: Nanostructured lipid carriers (NLC) developed from mixtures of solid lipid and spatially incompatible liquid lipid by solvent diffusion method. This new type of lipid nanoparticles offers the advantage of improved drug loading capacity and release properties. In this study, Glyceryl distearate and Glyceryl behenate were chosen as solid lipid and Glyceryl triacetate used as liquid lipid. Ubidecarenone used as model drug was incorporated into the NLC. The influences of different type of solid lipid and liquid lipid concentration on physiochemical properties of the NLC were characterized. As a result, the drug encapsulation efficiencies were improved by adding the liquid lipid into the solid lipid of nanoparticles. NLC had higher encapsulation efficiency and drug release. In addition, in vivo study showed that the antioxidant activity of the Ubidecarenone (Co. Q10 NLC) was more effective than the Ubidecarenone (Coenzyme Q10) solution form on DPPH scavenging, anti-lipid peroxidation, lowers the effect of amnesia induced by scopolamine and increased bioavailability observed in Cmax, Tmax, and AUC. These results indicated that nanostructured lipid formulation of Ubiquinone (Coenzyme Q10) has more antioxidant activity than that of solution form and it can be used to reduce the oxidative stress and to increase the antioxidant enzyme activity in many neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease etc.
    No preview · Article · Mar 2013 · Journal of Biomedical Nanotechnology
  • V.K. Nanjwade · F.V. Manvi · B.K. Nanjwade
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    ABSTRACT: In the present work an attempt has been made to prepare FDT of Lomefloxacin HCl with an view to enhance the patient compliance, and provide a quick onset of action, increasing the solubility and masking its bitter taste. Taste masking and solubility was enhanced by complexing Lomefloxacin HCl with hydroxyl propyl β cyclodextrin (HP-βCD) by solvent evaporation method. Prepared complex was further compressed into tablets by direct compression using different superdisintegrant like Sodium starch glycolate, Croscarmellose sodium, Polyplasdone XL-10 in different concentration such as 1%, 1.5%, 2 % using aspartame as a sweetener and aerosil as lubricant. The drug release from FDT increase with increasing the concentration of superdisintegrants and was found to be highest with formulation F6 containing 1.5 % Croscarmellose Sodium and was consider to be the best formulation which release upto 100.68 % in 45 min. In vivo studies revealed that FDT of formulation (F 6) showed good bioavailability compared to conventional tablet. The fast dissolving tablet with HP-βCD complex can be formulated using different superdisintegrants by Direct Compression technique and was found to be disintegrate less than 2 minute, which provide faster effect and better patient compliance.
    No preview · Article · Mar 2013 · International Journal of Drug Development & Research
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    ABSTRACT: The present study aims to prepare nanoparticles in form of aquasomes with Etoposide as a low solubility drug mode. Etoposide aquasomes were obtained through the formation of an inorganic core of calcium phosphate covered with a Lactose film and further adsorption of the Etoposide. The formulations were then characterized with respect to size and its surface morphology, zeta potential, entrapment efficiency, in vitro drug release profile, stability studies, in vivo tissue distribution studies and in vivo pharmacokinetic studies. The formulated Etoposide nanoparticles were spherical with a diameter ranging from 150 to 250 nm. Highest entrapment efficiency was found to be 88.41%. Highest cumulative percent drug release was observed with F-5 (79.19%) in 120 hrs. Formulation F-5 with optimal particle size, high entrapment efficiency and satisfactory in vitro release was selected for in vivo studies. The average targeting efficiency of drug loaded nanoparticles was found to be 42.54% of the injected dose in liver, 12.22% in lungs, 4.14% in kidney and 25.12% in spleen. The results revealed that, the drug loaded nanoparticles showed preferential drug targeting to liver followed by spleen, lungs and kidney. The in-vivo studies were carried out by HPLC method to assess the pharmacokinetic parameters like C max, t max, AUC, t 1/2. Formulation F-5 was selected for this study and it showed C max value of 1.48 μg/ml, t max of 2 hrs, AUC was 20.40 μg/ml and a t 1/2 of 13.5 hrs. Stability studies indicated that 4 °C is the most suitable temperature for storage of Etoposide nanoparticles. This drug delivery is endowed with several exclusive advantages and hence holds potential for further research and clinical application.
    No preview · Article · Mar 2013
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    ABSTRACT: To enhance the bioavailability of the poorly water-soluble drug Aceclofenac, a lipidnanoemulsion comprising ethanolic solution of phospholipid 90 G and tween 80 in 1:1 ratio (Smix), triacetin and anseed oil as oil phase and distilled water as aqueous phase, in the ratio of 55:15:30 (% w/w) was developed by constructing pseudo-ternary phase diagrams and evaluated for viscosity, % transmittance, and surface morphology of nanoemulsions. In vitro diffusion (release) of Aceclofenac from three different bases to an aqueous receptor phase through cellophane membrane was monitored spectrophotometrically at 273 nm. Compared with hydroalcoholic drug solution, oily solution, and conventional emulsion and suspension. The lipid-nanoemulsion showed increase in drug release compared to drug suspension. This may be attributed to increased solubility of the drug from nanosized emulsion.
    No preview · Article · Mar 2013 · International Journal of Drug Development & Research

  • No preview · Article · Jan 2013
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    ABSTRACT: The present study aimed to conceptualize pulsatile principles to develop a time dependent programmable pulsincap drug delivery system of 5-Fluorouracil, intended for chronotherapy in colorectal cancer. Microcapsules of 5-Fluorouracil were formulated by emulsification-solvent evaporation method using three different drug (5-Fluorouracil): polymer (Eudragit L-100 55) ratio (viz., 1:1, 1:2, & 1:3) and their physico-chemical properties were evaluated. The optimized formulation MC-2 was filled into formaldehyde treated hard gelatin capsules using different quantities (20 mg & 30 mg) of Gellan gum, Guar gum, Xanthan gum and Locust bean gum as hydrogel plugs to maintain a suitable lag period. Further modified capsules were coated with Eudragit S-100 (15%). In-vitro release studies of all the formulations showed that there was no drug release in acidic pH (0.1 N HCl) and in simulated intestinal fluid (pH 6.8 phosphate buffer). Drug release occurred in pH 7.4 upto 24 hrs in a controlled manner depending upon the quantity of hydrogel plug. All the formulations followed first order drug release kinetics and showed anomalous transport i.e., a combined mechanism of pure diffusion and Case II transport. Gamma scintigraphic studies concluded that the system released the drug in lower parts of GIT after a programmed lag time. In-vivo studies revealed that pulsincap system of formulation (F-3) showed good bioavailability compared to oral solution. Accelerated stability studies indicated that formulation F-3 was quite stable.
    No preview · Article · Jan 2013
  • S.S. Kerur · K.R. Alagawadi · H. Zhu · F.V. Manvi
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    ABSTRACT: In the present study, synthesis and antimicrobial activity of 2,5-disubstituted triazole derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, mass and elemental analysis. All compounds were screened for antitubercular and antibacterial activity. The results revealed that most of the compounds showed high or moderate biological activity against tested microorganisms.
    No preview · Article · Aug 2012 · Indian Drugs
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    ABSTRACT: The objectives of this study were to prepare and characterize the novel Lomefloxacin-Salicylic acid and Lomefloxacin-Urea to demonstrate the enhanced dissolution of Lomefloxacin by co crystal formation in comparison with the pure drug. Lomefloxacin-Salicylic acid and Lomefloxacin-Urea co crystal was prepared using greener technique cogriding with aim of enhancing their dissolution rate sand their bioavailability. DSC, IR and PXRD were used to characterize the novel solid form. The dissolution and chemical stability were assessed and compared with marketed Maxaquin. Pharmaceutical co crystals are new solid forms with physicochemical properties that appear promising for drug product development. Novel solid co crystals with distinct melting. DSC, FTIR and PXRD data was obtained. The co crystal of lomefloxacin with salicylic acid (SA) has been shown to have higher solubility than lomefloxacin. In this study, we aimed to characterize the pure drug and the co crystals with the salicylic acid and urea. Remarkably, two new co crystals of lomefloxacin were discovered in this study. The study indicates that the improved aqueous solubility of the co crystals leads to improved dissolution of Lomefloxacin. Thus, the co crystals are a viable alternative solid form that can improve the dissolution rate and bioavailability of poorly soluble drugs. Subsequently, differential scanning calorimetry was used to investigate the co crystal formation. The formation of co crystals was also verified using liquid-assisted grinding. The spectral patterns of lomefloxacin, salicylic acid and the complex were different. The physicochemical properties such as solubility and dissolution rate of this complex will be further investigated.
    No preview · Article · Jan 2012
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    ABSTRACT: Lipid-based formulations encompass a diverse group of formulations with very different physical appearance, ranging from simple triglyceride vehicles to more sophisticated formulations such as self-emulsifying drug delivery systems (SEDDS). Lipid-based drug delivery systems may contain a broad range of oils, surfactants, and co-solvents. They represent one of the most popular approaches to overcome the absorption barriers and to improve the bioavailability of poorly water-soluble drugs. Diversity and versatility of pharmaceutical grade lipid excipients and drug formulations as well as their compatibility with liquid, semi-solid and solid dosage forms make lipid systems most complex. Digestion of triglyceride lipids, physicochemical characteristics and solubilisation of lipid digestion products as well as intestinal permeability are some of the variable parameters of such formulations. Furthermore, among the factors affecting the bioavailability of the drug from lipid-based formulations are the digestion of lipid, the mean emulsion droplet diameter, the lipophilicity of the drug and the type of lipids. The solubility of the Active Pharmaceutical Ingredient in the Lipid System, the desorption/sorption isotherm and the digestibility of lipid vehicle are important issues to be considered for formulations of isotropic lipid formulations. This review also describes the fate of lipid formulations in the gut and the factors influencing the bioavailability from lipid-based formulations. Novel formulation systems and currently marketed products conclude this review.
    Full-text · Article · Dec 2011 · Scientia Pharmaceutica
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    ABSTRACT: The field of ocular drug delivery is one of the interesting and challenging endeavors facing the pharmaceutical scientist. Novel approaches for ophthalmic drug delivery need to be established to increase the ocular bioavailability by overcoming the inherent drawbacks of conventional dosage forms. In situ hydrogels are instilled as drops into the eye and undergoes a sol-to-gel transition in the cul-de-sac, improved ocular bioavailability by increasing the duration of contact with corneal tissue, thereby reducing the frequency of administration. The purpose of the present work was to develop an ophthalmic drug delivery system using three different gelling agents with different mechanisms for in situ gelation of Moxifloxacin hydrochloride, a fluoroquinolone antibiotic. polyox (a pH-sensitive gelling agent), sodium alginate (an ion-sensitive gelling agent), and poloxamer (a temperature-sensitive gelling agent) were employed for the formation of in situ hydrogel along with HPMC K4M as viscofying agent, which increases the residence time of the drug in the ocular cavity. The promising formulations MF4, MF5, and MF9 were evaluated for pH, drug content, in vitro gelation, in vitro drug release, in vivo drug release, ocular irritation, and stability. Percent drug content of 98.2, 98.76, and 99.43%; viscosity of 15.724 × 100, 16.108 × 100, and 15.213 × 100 cP at 20 rpm, cumulative percent release of 75.364, 74.081, and 71.752%, and C max of 1,164.16, 1,187.09, and 1,220.58 ng/ml was observed for formulation MF4, MF5, and MF9, respectively. The developed formulations were therapeutically efficacious, stable, and non-irritant and provided sustained release of the drug over 8 h.
    No preview · Article · Oct 2011 · European Journal of Drug Metabolism and Pharmacokinetics
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    ABSTRACT: Pulmonary drug delivery is a developing technology in which medication is inhaled through the lungs and enters the bloodstream through the alveolar epithelium. Pulmonary drug delivery provides a noninvasive, alternative method to subcutaneous injection, and also intravenous injection. The delivery device plays a major role in the efficiency of pulmonary delivery, and great strides have been made in the development of new devices in recent years. The devices most commonly used for respiratory delivery, including nebulizers, metered-dose inhalers, and dry powder inhalers, can all be adapted for use with protein/peptide drugs. The choice of device will depend on the drug, the formulation, the site of action, and the pathophysiology of the lungs. While a great deal of recent research has focused on the development of novel devices, attention must now be paid to the formulation of these macromolecular drugs. The emphasis in this review will be on targeting of drugs by inhalation using carriers (such as liposomes, microspheres, microparticles, and nanoparticles) and ligands.
    No preview · Article · Sep 2011
  • B.K. Nanjwade · D.B. Sonaje · F.V. Manvi
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    ABSTRACT: Aim: The use of steroids concomitantly with antibiotics is common to treat the severe and destructive inflammation, occurring during a bacterial infection of the external eye. In the present work, we have attempted to develop long acting eye drops containing ciprofloxacin and dexomethasone, a potent antibiotic and anti-inflammatory agent in the treatment of bacterial conjunctivitis. Methods: A clear ophthalmic solution and an ophthalmic suspension of the combination and ophthalmic solution of Ciprofloxacin alone were prepared and evaluated by various tests. Results: The ophthalmic solutions formulated using the Hydro xypropyl-beta-cyclodextrin (HP-beta-CD) exhibited better stability, biological activity and ocular tolerance in comparison to another ophthalmic pre parat ion formulated without thydroxypropyl-beta-cyclodextrin (HP-beta-CD). Conclusions: These eye-drops were found to be non-irritating to rabbit eyes and were found to be effective in prevention of non vascularisation in infected rabbit eyes.
    No preview · Article · Sep 2011 · International Journal of Pharmacy and Technology

  • No preview · Article · Jun 2011 · ChemInform
  • B.K. Nanjwade · J. Popat · R. Udhani · F.V. Manvi
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    ABSTRACT: The present study was aimed at preparing a novel time dependent pulsed release system for the programmed release of salbutamol sulphate for the treatment of nocturnal asthma. The core tablets of salbutamol sulphate were prepared using wet granulation containing a superdisintegrant. Physical characterization of tablet and powder blends used to form the core tablet was under taken using a range of experimental technique. Eudragit S100 and Eudragit L100 were used as pH dependent polymers for coating the core tablet. The ratio of Eudragit S100 and Eudragit L100 and the coating level was optimized using 3 2 full factorial designs. Factors studied in design were percentage of Eudragit S100 in combination with Eudragit L100 and the effect of coating level on in vitro drug release. Dissolution studies of tablets were carried out in media with different pH (1.2, 5.5, 6.8 and 7.4) showed that drug release in colon could be modulated by optimizing the concentration of Eudragit L100: Eudragit S100 (1:2). The study showed that, lag time prior to drug release was highly affected by the ratio of Eudragit L: Eudragit S. The dissolution data revealed that the level of coating and the ratio of polymers are very important to achieve an optimum formulation.
    No preview · Article · Jun 2011 · Indian Drugs
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    ABSTRACT: A major hurdle in pharmaceutical formulation is water insolubility of most of the drugs affecting stability and bioavailability of the drug, if the drug is also insoluble in organic medium, it is difficult to deliver the drug in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing the dissolution of poorly soluble drugs but has certain draw backs like low drug loading and large doses. However, a new solution to poorly water soluble drug candidates is now available i.e. nanonisation and it leads to much more soluble, more biologically available and safer dosage form of poorly soluble and poorly bioavailable drugs. In the present work, a nanocrystal of lovastatin was formulated by using simple precipitation method without using stabilizer or surfactant and it was found that formulation at 3 mM concentration of drug with the acetone and methanol as a solvent and at proper dilution (50 times) of drug solution with water, nanocrystals with less particle size is possible with slight change in crystallinity. It has also shown that, the drug has enhanced saturation solubility, increased dissolution rate and more bioavailable in biological fluid when drug formulated by using acetone and methanol as a solvent. Whereas drug formulation with acetonitrile has large particle size, less saturation solubility and low rate of dissolution.& copy 2011 Nanjwade BK, et al.
    No preview · Article · Mar 2011 · Journal of Nanomedicine & Nanotechnology
  • F.V. Manvi · B.K. Nanjawade · S. Shing
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    ABSTRACT: Anti-arthritic, anti-inflammatory and analgesic activity of combined extract of Annona squamosa and Nigella sativa was evaluated and validated in various animal models. Arthritis was induced by Complete Freund's Adjuvant (CFA) injection in metatarsal footpad of Sprague-Dawley rats. Degree of inflammation was evaluated by hind paw swelling and body weight, estimation of AST, ALT and TP supported by histopathology of knee joint. Combined extract reduced hind paw swelling, body weight, AST, ALT and TP Histopathology revealed significant reduction in mononuclear infiltration, pannus formation and bone erosion. Combined extract decreased the paw volume in carageenan treated rats. Combined extract (PHF) shows moderate central and peripheral analgesic activities in hot plate method and acetic acid induced writhing method in mice.
    No preview · Article · Jan 2011 · International Journal of Pharma and Bio Sciences
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    Vikesh Shukla · F. V. Manvi
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    ABSTRACT: Oral route of administration have wide acceptance up to 50-60% to total drug forms. Fast disintegrating drug delivery system has number of advantage such as faster onset of action, attractive elegance, ease of administration. In this study, an attempt has been made to study direct compression method, for formulation of fast disintegrating tablets of Isoniazid and Rifampicin, an anti- tubercular drug in view of enhancing bioavailability. These formulations have sufficient hardness and can be manufactured by commonly used equipment. Prior to formulation the pre-compression parameters were characterized for flow properties and prepared formulations were evaluated for physico-chemical parameters, X-ray powder crystallography, SEM and in-vivo bioavailability. All four formulations possessed good disintegration properties with total disintegration time of 25 to 40 seconds. The effects of different superdisintegrants and process variables on drug release profile and disintegration property were evaluated and results revealed the better drug release with different superdisintegrants such as Ac-di sol and Polyplastadone XL. All formulations are rapidly disintegrated in oral cavity as well as all formulations possess good anti-tubercular properties. SEM Showed the mechanical strength of the formulations affected the morphological changes after compression. Hence, it is evident from this study that fast dispersible tablets could be a promising delivery system for Isoniazid, Rifampicin and their combination with good mouth feel and improved drug availability with better patient compliance.
    Preview · Article · Jan 2011 · International Journal of Drug Delivery

Publication Stats

729 Citations
44.83 Total Impact Points

Institutions

  • 2003-2013
    • KLE College of Pharmacy
      • Department of Pharmaceutics
      Belgaum, Karnataka, India
  • 2009-2011
    • KLE University
      Belgaum, Karnataka, India
    • Karnataka College of Pharmacy
      Yelahanka, Karnataka, India
  • 2006
    • K L E Society's College of Engineering and Technology
      Belgaum, Karnataka, India