- Abstract: To observe the pathological changes of the lens and anterior lens capsule of the patients with familial congenital aniridia, and discuss the histopathological etiology of the fragility of the anterior capsule and the significance of surgical project. Anterior lens capsules and lens specimens were obtained from aniridic patients during cataract surgery. The intraoperative behavior of each capsule was noted, after which the specimens were submitted for histopathologic evaluation and electron... Show More
- Abstract: To explore the feasibility of reattaching the dislocated graft with viscoelastic in abnormally structured eyes after Descemet-stripping automated endothelial keratoplasty (DSAEK). Retrospective case series. Five pseudophakic bullous keratopathy cases (5 eyes) with a history of vitrectomy and/or iris-lens diaphragm injury. After DSAEK, graft dislocation occurred in each of the 5 cases (5 eyes). We attempted to fill the anterior chamber (AC) with an air bubble to push up the dislocated graft,... Show More
- Abstract: To investigate the clinical efficacy, prevention and management complications and choice of indication with Descemet membrane stripping with automated endothelium keratoplasty (DSAEK). Clinical case series. Nine patients (9 eyes) with bullous keratopathy underwent DSAEK procedure from Peking University Eye Center, Peking University Third Hospital during September to December in 2007. Visual acuity, cornea transparency, graft position, corneal thickness, curvature, astigmatism and endothelial... Show More
- Abstract: To study the change of corneal birefringence at different pressures in vitro to determine whether corneal birefringence changes along with pressure. The pattern of corneal birefringence was recorded at different intraocular pressures. The pressure differences were 0.10, 0.50 and 1.00 mm Hg, respectively. To compare the pattern sequence at two pressure values, a nonpaired t test was performed. Statistical analysis indicates that the difference of the corneal birefringence is significant when... Show More
- Abstract: To evaluate the effect and explore the complications of Descemet-stripping automated endothelial keratoplasty (DSAEK) combined with phacoemulsification cataract surgery or lens exchange in corneal endothelial dysfunction eyes with lens disorders. Retrospective case series. Eighteen consecutive cases (20 eyes) were performed DSAEK combined with lens surgery from December 2007 to December 2008 in Department of Ophthalmology, Peking University Third Hospital. Five cases (7 eyes) were performed... Show More
- Abstract: Purpose: To study the possible mechanism and treatment for pigment dispersion glaucoma (PDG) caused by single-piece acrylic (SPA) intraocular lens (IOL) ciliary sulcus fixation in Asian eyes. Materials and methods: Patients referred for PDG caused by SPA IOL ciliary sulcus fixation to our hospital from April 2005 to June 2011 were included. The patients' general information, IOL type, interval between initial surgery and PDG occurrence, examination findings, antiglaucoma medicine regimen... Show More
Publications citing this author (27)
[Show abstract] [Hide abstract] ABSTRACT: Aniridia is a rare panocular disorder affecting the cornea, anterior chamber, iris, lens, retina, macula and optic nerve. It occurs because of mutations in PAX6 on band p13 of chromosome 11. It is associated with a number of syndromes, including Wilm's tumour, bilateral sporadic aniridia, genitourinary abnormalities and mental retardation (WAGR) syndrome. PAX6 mutations result in alterations in corneal cytokeratin expression, cell adhesion and glycoconjugate expression. This, in addition to stem-cell deficiency, results in a fragile cornea and aniridia-associated keratopathy (AAK). It also results in abnormalities in the differentiation of the angle, resulting in glaucoma. Glaucoma may also develop as a result of progressive angle closure from synechiae. There is cataract development, and this is associated with a fragile lens capsule. The iris is deficient. The optic nerve and fovea are hypoplastic, and the retina may be prone to detachment. Aniridia is a profibrotic disorder, and as a result many interventions--including penetrating keratoplasty and filtration surgery--fail. The Boston keratoprosthesis may provide a more effective approach in the management of AAK. Guarded filtration surgery appears to be effective in glaucoma. Despite our increasing understanding of the genetics and pathology of this condition, effective treatment remains elusive.
- ) This often necessitates extraction with or without the insertion of an intraocular lens (IOL) implant. Histological studies performed on the anterior capsule of aniridia cataracts have found them to be very fragile (Schneider et al. 2003; Hou et al. 2005 ). One must be aware of this during cataract extraction in order to avoid capsule complications.
[Show abstract] [Hide abstract] ABSTRACT: Endothelial keratoplasty is at present the gold standard for surgical treatment of corneal endothelial pathologies not associated with significant corneal scar. Tremendous progress has been made in recent years in improving the technology of endothelial keratoplasty techniques, such as descemet stripping automated endothelial keratoplasty (DSAEK) and descemet membrane endothelial keratoplasty. In this review, we discuss the current techniques and outcomes of DSAEK.
- The problems encountered in such cases includes loss of the remaining field of vision due to the transient intraocular pressure (IOP) rise, difficulty in surgery due to presence of tube of the glaucoma valve, tube position contributing to corneal decompensation, and possibility of air escaping through the sclerostomy or tube or large iridotomy.[10,97]The various technical modifications that can be helpful in such cases include trimming of the tube if it extends centrally,placement viscoelastic between the graft and the iris to block the escape of air from the AC,suture closure of the iridotomy opening and meticulous monitoring of IOP.With the recent advancements in the techniques of EK, the surgery has become faster and safer with better visual outcomes. Further, an early rehabilitation of patients with DSAEK has made it the procedure of choice over full‑thickness PKP to be used in patients with endothelial dysfunction.