Yan-Sheng Hao's scientific contributionswhile working at Peking University Third Hospital (Beijing, China) and other institutions

Publications (7)

Publications citing this author (27)

    • ) This often necessitates extraction with or without the insertion of an intraocular lens (IOL) implant. Histological studies performed on the anterior capsule of aniridia cataracts have found them to be very fragile (Schneider et al. 2003; Hou et al. 2005 ). One must be aware of this during cataract extraction in order to avoid capsule complications.
    [Show abstract] [Hide abstract] ABSTRACT: Aniridia is a rare panocular disorder affecting the cornea, anterior chamber, iris, lens, retina, macula and optic nerve. It occurs because of mutations in PAX6 on band p13 of chromosome 11. It is associated with a number of syndromes, including Wilm's tumour, bilateral sporadic aniridia, genitourinary abnormalities and mental retardation (WAGR) syndrome. PAX6 mutations result in alterations in corneal cytokeratin expression, cell adhesion and glycoconjugate expression. This, in addition to stem-cell deficiency, results in a fragile cornea and aniridia-associated keratopathy (AAK). It also results in abnormalities in the differentiation of the angle, resulting in glaucoma. Glaucoma may also develop as a result of progressive angle closure from synechiae. There is cataract development, and this is associated with a fragile lens capsule. The iris is deficient. The optic nerve and fovea are hypoplastic, and the retina may be prone to detachment. Aniridia is a profibrotic disorder, and as a result many interventions--including penetrating keratoplasty and filtration surgery--fail. The Boston keratoprosthesis may provide a more effective approach in the management of AAK. Guarded filtration surgery appears to be effective in glaucoma. Despite our increasing understanding of the genetics and pathology of this condition, effective treatment remains elusive.
    Full-text · Article · Nov 2008
    • The problems encountered in such cases includes loss of the remaining field of vision due to the transient intraocular pressure (IOP) rise, difficulty in surgery due to presence of tube of the glaucoma valve, tube position contributing to corneal decompensation, and possibility of air escaping through the sclerostomy or tube or large iridotomy.[10,97]The various technical modifications that can be helpful in such cases include trimming of the tube if it extends centrally,[97]placement viscoelastic between the graft and the iris to block the escape of air from the AC,[98]suture closure of the iridotomy opening and meticulous monitoring of IOP.[10]With the recent advancements in the techniques of EK, the surgery has become faster and safer with better visual outcomes. Further, an early rehabilitation of patients with DSAEK has made it the procedure of choice over full‑thickness PKP to be used in patients with endothelial dysfunction.
    [Show abstract] [Hide abstract] ABSTRACT: Endothelial keratoplasty is at present the gold standard for surgical treatment of corneal endothelial pathologies not associated with significant corneal scar. Tremendous progress has been made in recent years in improving the technology of endothelial keratoplasty techniques, such as descemet stripping automated endothelial keratoplasty (DSAEK) and descemet membrane endothelial keratoplasty. In this review, we discuss the current techniques and outcomes of DSAEK.
    Full-text · Article · Jan 2017