[Show abstract][Hide abstract] ABSTRACT: The purpose of this study was to document the results of bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations (LMs), and the clinical data of 65 patients between October 2004 and October 2007 were reviewed.
Of the 65 patients in the study, 60 patients were given intralesional injection of bleomycin A5. Five patients underwent partial resection, and then an injection of bleomycin A5 for the remaining lesion. The outcomes were assessed by physical examination and Doppler ultrasonography scan. The follow-up time was from 6 months to 3 years after the last injection (mean, 16 months).
Among the 65 patients, 41 were men and 24 were women (1.7:1 male:female ratio), the age range was 3 months to 45 years (mean, 12 years). Thirty-two lesions (49%) were macrocystic, 30 (46%) were microcystic, and 3 (5%) were combined. Each patient received 1 to 10 injections (mean, 3.0 injections) for the whole course of treatment, and the total dose of bleomycin A5 was from 8 to 80 milligrams (mean, 24.0 mg). Twenty-six of 32 macrocystic lesions (81%) showed greater than 90% reduction, whereas another 6 (19%) exhibited 50% to 90% reduction. Nineteen of 30 microcystic lesions (63%) showed greater than 90% reduction; 10 (33%) had 50% to 90% reduction; and 1 (4%) had less than 50% size reduction. Of the 3 combined lesions, 2 (67%) had greater than 90% shrinkage, and 1 (3%) had less than 50% reduction. The complications included ulceration of oral mucosa, minor soft tissue atrophy, mild fever, and hematoma. There was no recurrence throughout the follow-up period.
These data suggest bleomycin A5 is a safe and effective intralesional agent for the treatment of macrocystic LMs, superficial oral mucosa LM, and localized deep microcystic lesions. For extensive macrocystic LMs involving contiguous anatomic areas and diffuse microcystic lesions involving deep tissues, bleomycin A5 injection combined with resection is necessary.
Full-text · Article · Jan 2011 · Journal of vascular surgery: official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter
[Show abstract][Hide abstract] ABSTRACT: In this study, we used a finite element method to evaluate the maximum Von Mises stresses in jaw bones of immediately loaded implant with different thread heights and widths, and the maximum displacements in implant-abutment complex. The implant thread height ranged from 0.20 to 0.60 mm, and the thread width ranged from 0.10 to 0.40 mm. Compared to those in standard designed implants, the maximum Von Mises stresses in cortical and cancellous bones with axially loaded implants decreased by 18.85% and 47.46%, respectively, and by 16.38% and 63.46%, respectively in buccolingually loaded implants. The maximum displacement of implant-abutment complex loaded axially and buccolingually decreased by 13.78% and 6.97%, respectively. These results indicated that thread height played more important roles in affecting bone stresses and implant-abutment complex stability than thread width. Immediately loaded cylinder implants with thread height exceeding 0.44 mm and width ranging from 0.19 to 0.23 mm caused the lowest stresses to the type B/2 bone.
Full-text · Article · Aug 2010 · Computers in Biology and Medicine
[Show abstract][Hide abstract] ABSTRACT: To investigate the incidence and the local factors of impacted permanent teeth, except for the third molar, in Chinese patients through an x-ray study.
A total of 548 impacted permanent teeth from panoramic radiographs were studied and recorded according to the patients' gender and age, tooth position, and classification of impaction. The local factors contributing to impacted permanent tooth were also investigated.
The incidence of impacted permanent teeth in the Chinese was 6.15%. The impacted tooth showed a predilection for women and was more common in the maxilla. The impaction of the canine had the greatest occurrence, 28.10% of all impacted teeth. Vertical impaction was most common (49.09%). The chief local factor for impacted teeth was the lack of interdental space (49.64%).
All permanent teeth can occur with impaction in Chinese patients. Dentists should perform a thorough evaluation before planning suitable treatment.
Full-text · Article · Apr 2010 · Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons
[Show abstract][Hide abstract] ABSTRACT: To make a preliminary study of the effect of low-intensity pulsed ultrasound on new bone formation during mandible distraction osteogenesis in dogs.
Bilateral surgical cuts were made in mandibles of 7 dogs between the first and second premolar regions. Anterior mandibles were lengthened by 20 mm at the rate of 1 mm/day twice a day. During the distraction period 1 lateral distraction gap was irradiated by low-intensity pulsed ultrasound for 10 minutes twice a day and the other side was sham irradiated as control. After distraction was completed, the dogs were sacrificed at 0, 1, 2, 4, 6, 8, and 12 weeks. Before sacrifice, dynamic bone imaging with technetium (99)m-methylene diphosphonate ((99)mTc-MDP) single-photon emission computed tomography was performed. Mandible samples were harvested. Then plain x-ray, dual-energy x-ray bone mineral density measurement, 3-dimensional computed tomography, and regular histologic examination were performed.
The (99)mTc-MDP bone imaging showed that uptake of (99)mTc-MDP in the experimental side was higher than in the control side at the early period of the consolidation time, but the outcome was later reversed. Plain x-ray showed that new bone of the experimental side was mature sooner than that of the control side. Bone mineral density in the experimental side was higher than that of the control side. Volume of new bone of the 2 sides had no significant difference. Histologic examination showed that trabeculae of the experimental side were more numerous and thicker than those of the control side at the early period of the consolidation time. Endochondral bone formation was observed in the experimental side.
Low-intensity pulsed ultrasound could accelerate bone formation during mandibular distraction osteogenesis and increase bone mineral density but had no effect on the volume of new bone.
No preview · Article · Nov 2009 · Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons
[Show abstract][Hide abstract] ABSTRACT: Our objective was to assess the value of (99m)technetium-methylene diphosphonate ((99m)Tc-MDP) bone imaging in the use of low-intensity pulsed ultrasound to promote bony formation during mandibular distraction osteogenesis in dogs. The body of the mandibles in 7 dogs were cut between the first and the second premolar and were lengthened at the rate of 1mm/day, twice a day, for 20 days. During the period of distraction one lateral distraction gap was irradiated with low-intensity pulsed ultrasound (LIPUS) for 10min twice a day, and the other side was used as control. Serial radiographic inspections were made at different periods (0, 1, 2, 4, 6, 8, and 12 weeks) during the consolidation phase, followed by a plain radiograph and histological examination. The (99m)Tc-MDP imaging showed that the ratio of bone formation on the LIPUS-treated side was significantly higher than that on the control side during the early period of consolidation (before the 4th week), but later this was reversed and there were no significant differences between the two sides by the 12th week. Plain radiographs and histological examination showed that the new bone on the experimental side had matured earlier than that on the control side. Radionuclide bone imaging is a good way to assess the formation of bone after distraction osteogenesis.
No preview · Article · Jun 2009 · British Journal of Oral and Maxillofacial Surgery
[Show abstract][Hide abstract] ABSTRACT: [Abstract] Objectives: To evaluate the effect of ultrasound-guided intralesional injection of Pingyangmycin on treatment of venous malformation in cervical-facial region. Methods: Seventy-five patients suffering from venous malformation, including 54 patients in the facial region, 8 patients in the submental region, 10 patients in the submandible region, and 3 patients in the cervical region, were treated by ultrasound-guided intralesional injection of Pingyangmycin. The size of the lesions ranged from 6mm9mm to 32mm39mm. The clinical outcomes and complications were recorded and evaluated. Results: The duration of follow-up ranged from 6 to 24 months. The average times of treatment were 1.64 times. Among them, 42 patients received only one time of treatment, 21 patients received two times, 9 patients received three times, and 3 patients received four times. The results were evaluated according to criteria of therapeutically effect. The results were excellent in 63 patients (84%), good in 10 patients (13.33%), and improved in 2 patients (2.67%). The successful rate was 97.33%. 71 patients (94.67%) had local swelling in injection region for several days and 2 patients (2.67%) developed temporary dizziness after treatment. There were no other complications recorded. Conclusions: Intralesional injection of Pingyangmycin has a good effect on venous malformation in the cervical-facial region under ultrasound guidance.