M Elia

University of Southampton, Southampton, England, United Kingdom

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Publications (364)1255.47 Total impact

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    ABSTRACT: Background & aims: Few trials have explored the effect of nutrition support on quality of life (QoL). This study examined the effects of oral nutritional supplements (ONS) vs dietary advice on QoL in malnourished care home residents. Methods: 104 malnourished, care home residents (medium + high risk), identified using the Malnutrition Universal Screening Tool ('MUST'), (mean age 88.5 ± 7.9y) were randomised to receive either oral nutritional supplements (ONS) (n = 53) or dietary advice (n = 51) for 12 weeks. Dietary intake was measured using 24 h dietary recall, and QoL assessed using EuroQol (EQ-5D), including time trade off (TTO) (range -0.59 to 1) and visual analogue scale (VAS) (score 0 to 100) for self-perceived health. Results: QoL (adjusted for baseline QOL, malnutrition risk, type of care received (nursing or residential)) was significantly higher in the ONS than the dietary advice group (intention to treat analysis at week 12; n = 104 ). EQ-5D TTO scores (mean ± SE) were 0.50 ± 0.04 vs 0.36 ± 0.05 (P = 0.005), VAS rescaled scores were 0.54 + 0.03 vs 0.046 + 0.03 (P = 0.006) and VAS scores were 61.3 ± 4.5 vs 54.6 ± 6.3 (P = 0.533) for ONS vs dietary advice respectively. Total energy, protein and the majority of micronutrient intakes were significantly greater in the ONS group, with energy intake being 423 kcal greater in the ONS than the dietary advice group at week 12. Conclusions: This study in malnourished care home residents indicates that ONS can improve QoL and nutritional intake more effectively than dietary advice alone. Clinical trial registry: This trial was registered with clinicaltrials.gov on 10th August 2007. Clinical trials identifier is NCT00515125http://www.clinicaltrials.gov/ct2/show/NCT00515125?term=nutrition+support&rank=60.
    No preview · Article · Jan 2016 · Clinical nutrition (Edinburgh, Scotland)
  • M Elia · C Normand · A Laviano · K Norman
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    ABSTRACT: Despite the clinical benefits of using standard (non-disease specific) oral nutritional supplements (ONS) in the community and care homes, there is uncertainty about their economic consequences. A systematic review was undertaken according to recommended procedures to assess whether ONS can produce cost savings and cost-effective outcomes. 19 publications with and without a hospital component were identified: 9 full text papers, 9 abstracts, and 1 report with retrospective analyses of 6 randomised controlled trials. From these publications a total of 31 cost and 4 cost-effectiveness analyses were identified. Most were retrospective analyses based on clinical data from randomised controlled trials (RCTs). In 9 studies/economic models involving ONS use for <3 months, there were consistent cost savings compared to the control group (median cost saving 9.2%; P < 0.01). When used for ≥3 months, the median cost saving was 5% (P > 0.05; 5 studies). In RCTs, ONS accounted for less than 5% of the total costs and the investment in the community produced a cost saving in hospital. Meta-analysis indicated that ONS reduced hospitalisation significantly (16.5%; P < 0.001; 9 comparisons) and mortality non-significantly (Relative risk 0.86 (95% CI, 0.61, 1.22); 8 comparisons). Many clinically relevant outcomes favouring ONS were reported: improved quality of life, reduced infections, reduced minor post-operative complications, reduced falls, and functional limitations. Of the cost-effectiveness analyses involving quality adjusted life years or functional limitations, most favoured the ONS group. The care home studies (4 cost analyses; 2 cost-effectiveness analyses) had differing aims, designs and conclusions. Overall, the reviewed studies, mostly based on retrospective cost analyses, indicate that ONS use in the community produce an overall cost advantage or near neutral balance, often in association with clinically relevant outcomes, suggesting cost effectiveness. There is a need for prospective studies designed to examine primary economic outcomes. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
    No preview · Article · Jul 2015 · Clinical nutrition (Edinburgh, Scotland)
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    M. Elia · C. Normand · K. Norman · A. Laviano
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    ABSTRACT: There is limited information about the economic impact of nutritional support despite its known clinical benefits. This systematic review examined the cost and cost effectiveness of using standard (non-disease specific) oral nutritional supplements (ONS) administered in the hospital setting only. A systematic literature search of multiple databases, data synthesis and analysis were undertaken according to recommended procedures. Nine publications comprising four full text papers, two abstracts and three reports, one of which contained 11 cost analyses of controlled cohort studies, were identified. Most of these were based on retrospective analyses of randomised controlled trials designed to assess clinically relevant outcomes. The sample sizes of patients with surgical, orthopaedic and medical problems and combinations of these varied from 40 to 1.16 million. Of 14 cost analyses comparing ONS with no ONS (or routine care), 12 favoured the ONS group, and among those with quantitative data (12 studies) the mean cost saving was 12.2%. In a meta-analysis of five abdominal surgical studies in the UK, the mean net cost saving was £746 per patient (se £338; P = 0.027). Cost savings were typically associated with significantly improved outcomes, demonstrated through the following meta-analyses: reduced mortality (Risk ratio 0.650, P < 0.05; N = 5 studies), reduced complications (by 35% of the total; P < 0.001, N = 7 studies) and reduced length of hospital stay (by ∼2 days, P < 0.05; N = 5 surgical studies) corresponding to ∼13.0% reduction in hospital stay. Two studies also found ONS to be cost effective, one by avoiding development of pressure ulcers and releasing hospital beds, and the other by gaining quality adjusted life years. This review suggests that standard ONS in the hospital setting produce a cost saving and are cost effective. The evidence base could be further strengthened by prospective studies in which the primary outcome measures are economic. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
    Full-text · Article · May 2015 · Clinical Nutrition
  • P D Austin · K S Hand · M. Elia
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    ABSTRACT: Administration of parenteral doses with microbial contamination can lead to infective morbidity or death. To test whether aseptic preparation of parenteral doses or additives to sterile doses undertaken in dedicated pharmaceutical rather than clinical environments reduces the risk of microbial dose contamination. Data identified from a systematic review were examined using random effects meta-analyses, and t-tests were used to compare dose contamination frequencies. In all, 16,552 doses from 34 studies (33 records) were identified. For all the data combined there was a significantly higher frequency of contamination of doses prepared in clinical than in pharmaceutical environments {3.7% [95% confidence interval (CI): 2.2, 6.2; N = 10,272 doses] vs 0.5% (95% CI: 0.1, 1.6; N = 6280 doses); P = 0.007}. Contamination of doses was significantly higher when prepared as individual lots than as part of a batch in pharmaceutical environments [2.1% (95% CI: 0.7, 5.8; N = 168 doses) vs 0.2% (95% CI: 0.1, 0.9; N = 6112 doses); P = 0.002]. There was a significantly higher frequency of dose contamination if additions were made to sterile parenteral doses in clinical environments [risk ratio: 2.121 (95% CI: 1.093, 4.114); P = 0.026]. The overall quality of the studies was judged to be low. Reported rates of parenteral dose contamination were orders of magnitude higher than accepted reference standards, which may increase infection risk. The limited evidence on contamination rates supports dose preparation in pharmaceutical rather than clinical environments, and does not support batch preparation in clinical environments. Copyright © 2015 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
    No preview · Article · May 2015 · Journal of Hospital Infection
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    ABSTRACT: Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different changes in total and resting EE and if (2) they influenced the level of adaptive thermogenesis, defined as the decline in total or resting EE not accounted by changes in body composition. Three groups of six, obese men participated in a total fast for 6days to achieve a 5% WL and a very low calorie (VLCD, 2.5MJ/day) for 3weeks or a low calorie (LCD, 5.2MJ/day) diet for 6weeks to achieve a 10% WL. A four-component model was used to measure body composition. Indirect calorimetry was used to measure resting EE. Total EE was measured by doubly labelled water (VLCD, LCD) and 24-hour whole-body calorimetry (fasting). VLCD and LCD showed a similar degree of metabolic adaptation for total EE (VLCD=-6.2%; LCD=-6.8%). Metabolic adaptation for resting EE was greater in the LCD (-0.4MJ/day, -5.3%) compared to the VLCD (-0.1MJ/day, -1.4%) group. Resting EE did not decrease after short-term fasting and no evidence of adaptive thermogenesis (+0.4MJ/day) was found after 5% WL. The rate of WL was inversely associated with changes in resting EE (n=30, r=0.-42, p=0.01). The rate of WL did not appear to influence the decline in total EE in obese men after 10% WL. Approximately 6% of this decline in total EE was explained by mechanisms of adaptive thermogenesis. Copyright © 2015. Published by Elsevier Inc.
    Full-text · Article · Apr 2015 · Metabolism: clinical and experimental
  • Elizabeth Isenring · Marinos Elia
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    ABSTRACT: The risk for malnutrition increases with age and presence of cancer, and it is particularly common in older cancer patients. A range of simple and validated nutrition screening tools can be used to identify malnutrition risk in cancer patients (e.g., Malnutrition Screening Tool, Mini Nutritional Assessment Short Form Revised, Nutrition Risk Screening, and the Malnutrition Universal Screening Tool). Unintentional weight loss and current body mass index are common components of screening tools. Patients with cancer should be screened at diagnosis, on admission to hospitals or care homes, and during follow-up at outpatient or general practitioner clinics, at regular intervals depending on clinical status. Nutritional assessment is a comprehensive assessment of dietary intake, anthropometrics, and physical examination often conducted by dietitians or geriatricians after simple screening has identified at-risk patients. The result of nutritional screening, assessment and the associated care plans should be documented, and communicated, within and between care settings for best patient outcomes. Copyright © 2015 Elsevier Inc. All rights reserved.
    No preview · Article · Jan 2015 · Nutrition
  • M. Naghibi · T.R. Smith · M. Elia
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    ABSTRACT: Background and aims Inoperable bowel obstruction is the most common and judicious indication for long term parenteral nutrition in patients with palliative malignancy. Considerable uncertainty exists about the survival length, quality of life (QOL) and associated health economics of home parenteral nutrition (HPN) for this patient group. Methods A systematic review was carried out for survival length and QOL of adult patients treated with HPN due to malignancy causing inoperable bowel obstruction in the palliative phase. Whenever possible, individual patient data were extracted to allow meta-analyses. Health economic evaluation was undertaken to calculate cost and incremental cost effectiveness ratio (ICER). Results Twelve studies involving 437 patients, met the inclusion criteria. Meta-analyses of extracted survival length data, representing the largest published cohort of HPN patients with palliative malignancy and inoperable bowel obstruction (n = 244 patients), revealed a mean survival of 116 days, median 83 days, with 45% and 24% still alive at 3 and 6 months, and only 2% survival at one year. Limited evidence suggests QOL deteriorated before death in a highly symptomatic group. The ICER is £176,587 per quality adjusted life year. Conclusions This is the first health economic evaluation and systematic review of survival and QOL for patients with inoperable bowel obstruction receiving HPN during the palliative phase of malignancy. Meta-analyses reveal a short survival and health economic analysis demonstrates high associated costs. This information can be used by clinicians to inform and guide selection of patients in this cohort for HPN treatment.
    No preview · Article · Sep 2014 · Clinical Nutrition
  • P.F. Collins · R.J. Stratton · M. Elia

    No preview · Article · Sep 2014
  • P. Austin · K.S. Hand · M. Elia

    No preview · Article · Sep 2014
  • P. Austin · K.S. Hand · M. Elia

    No preview · Article · Sep 2014
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    ABSTRACT: Malnutrition is common amongst hospitalised older patients and associated with increased morbidity and mortality. Poor dietary intake results from factors including acute illness and cognitive impairment but additionally patients may have difficulty managing at mealtimes. Use of volunteers to help at mealtimes is rarely evaluated. To obtain multiple perspectives on nutritional care of older inpatients, acceptability of trained volunteers and identify important elements of their assistance. A qualitative study 1 year before and after introduction of volunteer mealtime assistants on one ward and parallel comparison with a control ward in a Medicine for Older People department at a UK university hospital. Semi-structured interviews and focus groups, in baseline and intervention years, with purposively sampled nursing staff at different levels of seniority; patients or close relatives; and volunteers. At baseline staff felt under pressure with insufficient people assisting at mealtimes. Introducing trained volunteers was perceived by staff and patients to improve quality of mealtime care by preparing patients for mealtimes, assisting patients who needed help, and releasing nursing time to assist dysphagic or drowsy patients. There was synergy with other initiatives, notably protected mealtimes. Interviews highlighted the perceived contribution of chronic poor appetite and changes in eating patterns to risk of malnutrition. Improved quality of mealtime care attributed to volunteers’ input has potential to enhance staff morale and patients’/relatives’ confidence. A volunteer mealtime assistance scheme may work best when introduced in context of other changes reflecting commitment to improving nutrition. (i) A mealtime assistance scheme should incorporate training, supervision and support for volunteers; (ii) Good relationships and a sense of teamwork can develop between wards staff and volunteers; (iii) Impact may be maximised in the context of ‘protected mealtimes’.
    Full-text · Article · Aug 2014 · International Journal of Older People Nursing
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    ABSTRACT: Background: Recommendations effectively restrict the infusion duration of lipid-containing parenteral nutrition (PN) from a single bag, purportedly because it encourages growth of potential microbial contaminants more than lipid-free PN. Since other variables, including osmolarity, may independently affect microbial growth, this study examined variables affecting growth of Escherichia coli and Enterococcus durans in PN infusates. Materials and Methods: Growth of E coli and E durans was assessed in quadruplicate in 12 different PN infusates, with and without lipid, in varying glucose concentrations. Results: Results are presented as mean log10 colony-forming units (cfu)/mL ± SEM at 48 hours. The log10cfu/mL of both E coli and E durans in PN increased considerably after adjustment for baseline log10cfu/mL and pH, from 1.093 to 2.241 (P < .001) and from 0.843 to 3.451 (P < .001) respectively. Growth of each microorganism was independently increased by lipid inclusion, or increasing the proportion of nonnitrogen energy from lipid, and reduced by raising the glucose concentration or energy density. Increasing the osmolarity of lipid-PN with glucose or sodium chloride reduced growth but only significantly for sodium chloride (E coli, P = .025; E durans, P = .045). Induced changes in pH affected the growth of the 2 organisms differently. Conclusion: The presence of lipid and an increasing proportion of energy from lipid in PN favored the growth of E coli and E durans. Osmolarity changes and the nutrient type causing these changes independently affect the growth of these microbes. Each effect needs to be considered when establishing guidelines based on the growth of potential contaminants in different types of PN.
    No preview · Article · Jun 2014 · Journal of Parenteral and Enteral Nutrition
  • M Naghibi · M Stroud · Tr Smith · M Elia
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    ABSTRACT: There is controversy about the indications for home parenteral nutrition (HPN) during the palliative phase of malignancy causing inoperable gastrointestinal obstruction (IBO). This is partly due to uncertainty about the survival of patients. This study aimed to establish the survival characteristics of these patients in order to inform decisions about the use of HPN.
    No preview · Article · Jun 2014 · Gut
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    ABSTRACT: To determine the feasibility and acceptability of using trained volunteers as mealtime assistants for older hospital inpatients. Poor nutrition among hospitalised older patients is common in many countries and associated with poor outcomes. Competing time pressures on nursing staff may make it difficult to prioritise mealtime assistance especially on wards where many patients need help. Mixed methods evaluation of the introduction of trained volunteer mealtime assistants on an acute female medicine for older people ward in a teaching hospital in England. A training programme was developed for volunteers who assisted female inpatients aged 70 years and over on weekday lunchtimes. The feasibility of using volunteers was determined by the proportion recruited, trained, and their activity and retention over one year. The acceptability of the training and of the volunteers' role was obtained through interviews and focus groups with 12 volunteers, nine patients and 17 nursing staff. Fifty-nine potential volunteers were identified: 38 attended a training session, of whom 29 delivered mealtime assistance, including feeding, to 3911 (76%) ward patients during the year (mean duration of assistance 5·5 months). The volunteers were positive about the practical aspects of training and ongoing support provided. They were highly valued by patients and ward staff and have continued to volunteer. Volunteers can be recruited and trained to help acutely unwell older female inpatients at mealtimes, including feeding. This assistance is sustainable and is valued. This paper describes a successful method for recruitment, training and retention of volunteer mealtime assistants. It includes a profile of those volunteers who provided the most assistance, details of the training programme and role of the volunteers and could be replicated by nursing staff in other healthcare units.
    Full-text · Article · Mar 2014 · Journal of Clinical Nursing

  • No preview · Article · Sep 2013 · Clinical Nutrition
  • L. Bakewell · T. Smith · M. Stroud · M. Elia

    No preview · Article · Sep 2013 · Clinical Nutrition

  • No preview · Article · Sep 2013 · Clinical Nutrition
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    ABSTRACT: Background:Mosttechniquesformeasuringbodycompositionare basedon2-componentmodels(2-CMs)anddependonassumptions relating to the constancy of the density (DFFM) and hydration frac- tion (HFFFM) of fat-free mass (FFM). Objectives: The objectives were to determine whether these as- sumptions are systematically violated in patients with cirrhosis and to assess the validity of the estimates of body composition obtained in these patients by using 2-CM techniques. Design: Body composition was assessed by using a 4-component model (4-CM), which was based on data obtained from densitome- try,deuteriumdilution,anddual-energyX-rayabsorptiometry,in20 patients with cirrhosis who had no evidence of fluid retention and in 20pair-matchedhealthycontrolsubjects.Theresultswerecompared with those obtained by using "reference" and "bedside" 2-CM tech- niques. Results: The mean (SD) DFFM was significantly lower in the patientswithcirrhosis(1.0910.008comparedwith1.1000.006 kg/L; P 0.001); no significant difference in HFFFM was observed betweenthepatientsandcontrolsubjects(74.52.6comparedwith 73.5 2.1), although there was greater variability in the patients. Significantdifferenceswereobservedinthebody-compositionvari- ables obtained by using the "reference" 2-CM techniques compared with the 4-CM—the 95% limits of agreement in the patients with cirrhosis exceeded 5% body fat and 3 kg FFM; the corresponding valuesforthe"bedside"2-CMtechniqueswere11%bodyfatand7.5 kg FFM. Conclusions: Assumptions relating to the constancy of the DFFM and HFFFM are violated in patients with cirrhosis. Thus, standard 2-CM techniques provide inaccurate body composition estimates in this patient population. Am J Clin Nutr 2006;84:1151-62.
    Full-text · Article · Aug 2013 · American Journal of Clinical Nutrition
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    ABSTRACT: The adverse effects of disease-related malnutrition (DRM) on health care use and costs are well substantiated. However, the impact of managing DRM with nutritional support on health care use, including hospital (re)admissions requires exploration. This systematic review (9 RCT, n=1190) examined the effects of oral nutritional supplements (ONS) on hospital (re)admissions. Meta-analysis of 6 RCT (n=852) with data on the proportion of patients (re)admitted to hospital showed significant reductions with ONS vs. routine care (OR 0.59, 95% CI 0.43 to 0.80, P=0.001), including 5 RCT (n=826) that recorded readmissions (OR 0.59, 95% CI 0.43 to 0.80), P=0.001). The significant reduction in (re)admissions was found in meta-analyses of ONS trials in various settings and in patients with DRM or of varied nutritional status. A larger meta-analysis (8 RCT, n=999) that combined other (re)admissions data using standardised differences also showed a significant reduction with ONS (effect size -0.23, 95% CI -0.36 to -0.10, P=0.001). Most of these trials (75%) were in older people aged ≥65 years (6 RCT, n=834, effect size -0.18, 95% CI -0.31 to -0.04, P=0.011). This systematic review shows that ONS significantly reduce hospital (re)admissions, particularly in older patient groups, with economic implications for health care.
    No preview · Article · Jul 2013 · Ageing research reviews
  • Peter D Austin · Kieran S Hand · Marinos Elia
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    ABSTRACT: Because lipid putatively encourages contaminant growth it has been proposed that infusion of lipid-containing parenteral nutrition (PN) bags should be restricted to 24 h (48 h or longer if lipid free). This study aimed to examine this proposal by identifying factors affecting Candida albicans growth in PN. C. albicans growth was assessed in quadruplicate in 12 PN infusates, with and without lipid and varying glucose concentrations. The results are presented as mean ± SEM. Baseline log10 colony forming units (cfu)/mL (1.806 ± 0.015) increased substantially by 48 h in the PN infusates (to 3.731 ± 0.059). In PN infusates (pH 6.14 ± 0.01) growth was unaffected by the presence of 5% w/v lipid (0.246 ± 0.156 log10 cfu/mL decrease; P = 0.127), and independently suppressed by increasing glucose concentration (0.438 ± 0.174 log10 cfu/mL decrease per 10% increase in w/v glucose; P = 0.018). In a separate analysis growth was suppressed by increasing energy density (0.520 ± 0.179 log10 cfu/mL decrease per 1000 kcal non-nitrogen energy in 2 L; P = 0.007), without a significant effect of % non-nitrogen energy from lipid (0.056 ± 0.036 log10 cfu/ml increase per 10%; P = 0.082). Using a framework developed to examine growth of potential contaminants in PN, the inclusion of lipid emulsion in PN produced no specific effect on the growth of C. albicans, other than by increasing energy density. Growth was independently suppressed by increasing either glucose concentration or non-nitrogen energy density.
    No preview · Article · Jul 2013 · Clinical nutrition (Edinburgh, Scotland)

Publication Stats

9k Citations
1,255.47 Total Impact Points


  • 2001-2015
    • University of Southampton
      • • Institute of Human Nutrition
      • • MRC Lifecourse Epidemiology Unit
      Southampton, England, United Kingdom
  • 2008-2014
    • University Hospital Southampton NHS Foundation Trust
      Southampton, England, United Kingdom
  • 2012
    • University of Vermont
      Burlington, Vermont, United States
  • 2005
    • American University Washington D.C.
      Washington, Washington, D.C., United States
  • 1984-2003
    • University of Cambridge
      • Division of Biological Anthropology
      Cambridge, England, United Kingdom
  • 2002
    • Medical Research Council Unit, The Gambia Unit
      Bakau, Banjul, Gambia
    • Institute for Child Health Policy (ICHP)
      Колумбия, Tennessee, United States
  • 1998
    • University of Auckland
      • Department of Medicine
      Окленд, Auckland, New Zealand
  • 1995
    • CUNY Graduate Center
      New York, New York, United States
    • Queen's University Belfast
      • Institute of Clinical Sciences
      Béal Feirste, N Ireland, United Kingdom
  • 1991
    • Shrewsbury and Telford Hospital NHS Trust
      Shrewsbury, England, United Kingdom
  • 1989
    • MRC Clinical Sciences Centre
      London Borough of Harrow, England, United Kingdom
  • 1988
    • Ankara University
      • Department of Gastroenterology
      Engüri, Ankara, Turkey