Handan Inönü

Gaziosmanpasa University, Dazimon, Tokat, Turkey

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Publications (11)3.83 Total impact

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    H. Inönü · E. Naseri · S. Çelikel · A.C. Pazarli · I. Etikan

    Full-text · Dataset · Dec 2015
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    Full-text · Dataset · Dec 2015
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    ABSTRACT: Purpose: To evaluate the effects of chronic obstructive pulmonary disease (COPD) on retina and optic nerve. Methods: Thirty-eight patients with COPD and 29 healthy controls, totally 67 subjects, were included in the study. Visual evoked potentials (VEP) and visual field assessment (both standard achromatic perimetry (SAP) and short-wavelength automated perimetry (SWAP)) were performed on each subject after ophthalmological, neurological and pulmonary examinations. Results: Mean deviation (MD), pattern standard deviation (PSD) and corrected pattern standard deviation (CPSD) were significantly different between patient and control groups as for both SAP and SWAP measurements (p = 0.001, 0.019, 0.009 and p = 0.004,0.019, 0.031, respectively). Short-term fluctuation (SF) was not statistically different between the study and the control groups (p = 0.874 and 0.694, respectively). VEP P100 latencies were significantly different between patients with COPD and the controls (p = 0.019). Conclusion: Chronic obstructive pulmonary disease is a systemic disease, and hypoxia in COPD seems to affect the retina and the optic nerve.
    Full-text · Article · Apr 2012 · Acta ophthalmologica
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    H. Inönü · E. Naseri · S. Çelikel · A.C. Pazarli · I. Etikan
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    ABSTRACT: Background: In this study, we evaluated the pulmonary functions three months and three years after heart surgery. Methods: Twenty-five patients (19 males, 6 females; mean age 55.5±13.4 years; range 17 to 77 years) who underwent elective open heart surgery between August 2005 and March 2006 in the Cardiovascular Surgery Clinic of our hospital were prospectively evaluated. Pulmonary function tests (PFT) and arterial blood gas (ABG) analyses were performed before the operation and in the 3rd month and 3rd year after the operation. Results: Sixty four percent of 25 patients had coronary artery bypass graft (CABG) surgery, 20% of them had valve replacement surgery (VRS), while 16% of them had both CABG and VRS. The stage of heart failure before the surgery, was class III in 68% of patients, class II in 24%, and class IV in 8% according to the New York Heart Association (NYHA) heart failure classification. When compared to preoperative values, the difference in the postoperative 3rd month a nd 3rd year values of the PFT parameters VC, FEV1, FVC, FEF25, FEF50, FEF75 and MMEF was statistically significant (p=0.0001), whereas the difference was not significant in terms of FEV1/FVC ratio and PEF (p>0.05). There was no difference between the preoperative and postoperative ABG values (p>0.05). Conclusion: The most important result of this study is that the PFT parameters after three years were significantly lower than the preoperative values. This result is remarkable since it shows that the functional changes that develop after the operation persist at the end of 3rd year.
    Full-text · Article · Jan 2011 · Turkish Journal of Thoracic and Cardiovascular Surgery
  • Handan Inönü · Oğuz Köktürk
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    ABSTRACT: Sleep disorders are common in patients with end-stage renal disease. Daytime sleepiness, restless legs syndrome, periodic limb movement disorder, insomnia, sleep apnea syndrome are the most disturbances. Usually, sleep-related complaints are attributed to uremia because of similar symptoms, and this may cause to delayed diagnosis. Sleep disorders are negative effect on quality of life and compliance to treatment of patients as well as cause increased mortality and morbidity. Therefore, sleep disorders should be evaluated as a different clinical entity in patients with chronic kidney failure or receiving renal replacement therapy. In this article, we aimed to review of etiology, pathogenesis and treatment of common sleep disorders in end-stage renal failure in sight of related literature information.
    No preview · Article · Oct 2010 · Tuberkuloz ve toraks
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    ABSTRACT: To evaluate the knowledge and manner of cafe, pub and restaurant (with/without alcohol) workers in our city center about the ban on restriction of indoor smoking. To determine the preparation about the ban, smoking characteristics of workers, the knowledge on passive smoking. A questionnaire was performed to workers. The type of workplace, the number of workers, existence of a restriction of indoor smoking, any preparation about the ban were asked. The job of worker, whether the worker has a knowledge on the ban or not, the idea of the workers on the necessity and practicability of the ban were asked. Smoking history and the knowledge about passive smoking of workers were recorded. Fagerstrom nicotine dependent test (FNDT) was performed to smokers. Eighty four work places with 568 workers included in the study. The questionnaire was performed to 337 workers whose mean age was 29.1/years. 292 of workers were male. 190 of cases were current smokers. 166 of cases (49.3%) know the meaning of passive smoking. Alcohol offering was made at 8 of workplaces. Smoking was forbidden in 20 of workplaces. A preparation was performed about the ban in 30 of (46.9%) other workplaces. 88.4% of workers have knowledge on the ban, 64.7% of them know the punishment of the noncompliance of the ban. 81.3% of the workers believe the necessity and 45.7% of them believe the practicability of the ban. Smokers and especially who's FNBT > 5 have a stronger belief on the necessity and practicability of the ban. We determined that the preparation about the ban was inadequate although there was an little time for the put into practice the law. So we think that the controls of workplaces should be happened frequent.
    No preview · Article · Jul 2010 · Tuberkuloz ve toraks
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    ABSTRACT: The goal of asthma treatment is to achieve clinical control. The aim of this study was to compare the role of measurement of nitric oxide and its products in exhaled breath condensate and asthma control questionnaire (ACQ), level of asthma control (LAC) according to GINA guidelines and bronchial provocation test (BPT) in assessing asthma control in cases with stable asthma. Thus, 47 patients with the diagnosis of stable asthma and 42 individuals in the control group were enrolled in the study. The mean ages of the patient and the control groups were 44 +/- 11 and 47 +/- 11 years, respectively. While there was no significant relation between LAC and levels of nitric oxide, nitrite and nitrate, there was a significant relation between ACQ and mini quality of life questionnaire (p< 0.001). In the group with positive BPT, ACQ scores and absolute serum eosinophil values were significantly higher (p< 0.05), and FEV(1)/FVC and PEF percentages were significantly lower than those of the group with negative BPT (p< 0.05). Reversibility was significantly higher in participants with positive BPT than in those with negative BPT (11.2 +/- 7.4 and 6.9 +/- 6.6, respectively; p< 0.05). There was no significant relationship between nitric oxide, nitrite, nitrate in the exhaled breath condensate and ACQ, LAC, BPT and pulmonary function tests (p> 0.05). In conclusion, it was found that the levels of exhaled breath condensate nitric oxide, nitrite and nitrate were not sufficient for determining the level of asthma control in patients with stable asthma. It was concluded that the currently available asthma control questionnaires may be adequate for assessing asthma control.
    No preview · Article · Jun 2010 · Tuberkuloz ve toraks
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    ABSTRACT: Objective: In this study, our aim was to evaluate the general characteristics of the malignant pleural mesethelioma (MPM) cases, value of interventions used for diagnosis and to define the mortality of cases. Material and Method: Records of patients were evaluated retrospectively. Records of the Population Registry Office of Tokat were used to determine the median survival rate and mortaliy at 6, 12, 24 and 48 months. Results: Thirty five MPM patients were included in the study. The mean age was 61.5 years, and 17 of them were males. The most common complaint was dyspnea (86%), 24 of them had a history of environmental asbestos exposure. The value of diagnostic interventions was analyzed by the data of 27 patients who were diagnosed in our hospital. The cytology of pleural effusion was diagnostic in 7 of 24 samples (29%), and closed pleural biopsy in 10 of 22 samples (46%). Thoracoscopic biopsy was performed in 13 patients and and excisional biopsy from the chest wall in one patient, and all were diagnostic. Eight of 27 patients were diagnosed as epithelial type MPM, 17 patients (63%) could not be classified. All of the 13 patients whose samples were stained immunohistochemically showed strong / intermediate positivity for calretinin. Immunohistochemical staining was not useful in differentiating subtypes in 5 patients. Median survival was 14.9 months for all patients. Three patients (8.6%) died in the first six months. The mortalities for 12, 24 and 48 months were 42%, 65%and 100%, respectively. Conclusion: MPM should be considered in cases who had a history of asbestos exposure. Immunohistochemical staining should be perfomed for differentiating subtypes.
    No preview · Article · Mar 2010 · Turk Toraks Dergisi
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    ABSTRACT: The aim of this study was to determine the primary drug resistance rates and genotypes of resistant Mycobacterium tuberculosis strains isolated in the Kelkit Valley. Materials and Methods: Primary resistance to isoniazid (INH), rifampicin (RIF), ethambutol (ETB), and streptomycin (SM) was determined with the BACTEC 460 radiometric system. Forty-eight resistant M. tuberculosis strains isolated from tuberculosis patients living in the Kelkit Valley were genotyped using the spoligotyping method. Results: Approximately 11.6% of the strains were resistant against at least one major drug, and 8.3% were resistant against more than one drug. Single-drug resistance for INH, ETB, SM, and RIF was found as 5.8%, 2.1%, 3.7%, and 0.0%, respectively. Two or more drug resistance rates for SM + ETB, SM + INH, INH + RIF, RIF + ETB, INH + ETB + RIF, SM + ETB + INH and INH + ETB + RIF + SM were determined as 0.8%, 1.7%, 0.4%, 0.8%, 2.9%, 0,4%, and 1.2%, respectively. Fifteen spoligotype groups were created when the results were compared with the world databank (SpolDB4). Families of four strains could not be determined. The spoligotype groups most frequently encountered in our study were ST4 (n = 10, 20.8%), ST53 (n = 6, 12.5%), ST7 (n = 4, 8.3%), ST41 (n = 4, 8,3%) and ST31 (n = 4, 8.3%), and the most frequently encountered families were TI (n = 18, 37.5%), S (n = 12, 25%) and LAM-7 TUR (n = 4, 8.3%). Conclusions: High rates of primary resistance against major anti-tuberculosis drugs, the LAM-7 TUR clone, and high grouping rates were detected in this study, the first such study carried out in the Kelkit Valley.
    No preview · Article · Feb 2009 · Turkish Journal of Medical Sciences
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    ABSTRACT: Wegener's granulomatosis is a type of vasculitis characterized by necrotizing granulomatosis respiratory tract lesions and necrotising glomerulonephritis. Nasal, lung and renal biopsies and positive antineutrophil cytoplasmic antibody (c-ANCA) analysis is helpful in diagnosis. Early diagnosis and treatment is critical in prognosis. A 42 years-old male had dyspnea, coughing, hemoptysis, fatigue, loss of appetite, night sweating and arthralgia. Violaceous palpable, purpuric lesions were detected on the sublingual region of the mouth. On chest X-ray, there was nonhomogeneous infiltration in the parenchyma of both lungs. There was alveolar density involving upper lobes of both lungs detected in thoracal computerized tomography as well as patchy densities on the right lung upper-middle lobes. A nasal mucosa biopsy showed strongly destructive vasculitis. c-ANCA test was positive. We report an unusual case with Wegener's granulomatosis, characterized by a rare presentation of tongue involvement and atypical lung radiology with alveolar opacity.
    No preview · Article · Jan 2009 · Tuberkuloz ve toraks
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    ABSTRACT: In our country quartz is widely used for denim sandblasting and new cases with silicosis are defined. Silicosis is a preventable occupational lung disease caused by inhaled dust containing crystalline silica and no effective treatment for silicosis is available (1). CASE 1: A 23-years old man was admitted to the hospital with dyspnea on effort and cough. He had worked in a denim manufacturing factory for three years at sandblasting and dyeing. Physical examination revealed decreased breath sounds. Chest X-ray showed bilateral reticulonodular densities predominantly at middle and lower zones and minimal pneumothorax. Hypoxemia was determined in arterial blood gas analysis (BGA). Pulmonary function tests (PFTs) showed restrictive disorder. Lymphocytic alveolitis was demonstrated in the bronchoalveolar lavage fluid. Open lung biopsy revealed interstitial fibrosis and foreign particles which were seen more clearly under polarized light in interstitial areas. The patient was diagnosed as accelerated silicosis. CASE 2: A 25-years old man was admitted to the hospital with shortness of breath and haemopthysis. Two years ago, he had worked at the same place for 1.5 years. Bilateral reticulonodular densities at middle and lower zones and minimal unilateral pneumothorax were seen in chest X-ray. Restrictive disorder at PFT and hypoxemia in BGA were observed. Because of the similarity of complaints, radiological findings and occupational history with the former patient, no other further and invasive procedure was planned and the patient was diagnosed as accelerated silicosis. CONCLUSION: The usage of sandblasted denims increase recently and denim sandblasting is being frequently made especially in small work places. Since there is no definite treatment for silicosis, it is important to take necessary precautions to improve the conditions of the factories.
    Full-text · Article · Jan 2007 · Tuberkuloz ve toraks