Cheng-Yu Lo

Far Eastern Memorial Hospital, T’ai-pei, Taipei, Taiwan

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Publications (10)19.7 Total impact

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    ABSTRACT: Epithelioid inflammatory myofibroblastic sarcoma (E-IMS) is a recently established rare variant of inflammatory myofibroblastic tumor. It is characterized by a distinctive constellation of clinical, pathological, and molecular features, including a nearly exclusive intraabdominal location, strong male predilection, aggressive clinical course, predominance of epithelioid tumor cells, and Ran-binding protein 2 (RANBP2)-anaplastic lymphoma kinase (ALK) fusion in the majority of cases. To the authors' knowledge, the cytologic features of E-IMS have not been described to date. Cases of E-IMS that had corresponding cytology were searched. Six cytology samples (1 fine-needle aspiration sample, 2 imprint samples, and 3 effusion fluids) containing tumor cells were identified in 5 patients with E-IMS. The cytomorphology included large monotonous epithelioid cells arranged in loose aggregates or singly, with admixed myxoid stroma, and an inflammatory background rich in neutrophils. The tumor cells had a large, round, eccentric nucleus with vesicular chromatin, prominent nucleoli, and moderate amounts of pale cytoplasm. Delicate thin-walled branching vessels traversing tumor aggregates was a prominent feature in a fine-needle aspiration sample. Immunohistochemically, ALK was positive in all 5 tumors, with a nuclear membranous staining pattern noted in 3 cases and a cytoplasmic pattern observed in the other 2 cases. ALK rearrangement was confirmed in all 5 tumors by molecular genetic studies. The cytologic features of E-IMS recapitulate its histologic characteristics. E-IMS merits inclusion in the differential diagnosis of any intraabdominal, large epithelioid cell neoplasm. Confirmation of ALK rearrangement is advisable because patients may benefit from targeted therapies. Cancer (Cancer Cytopathol) 2015. © 2015 American Cancer Society. © 2015 American Cancer Society.
    Full-text · Article · Jul 2015 · Cancer Cytopathology
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    Wei-Fan Hsu · Cheng-Yu Lo · Chen-Shuan Chung

    Full-text · Article · Apr 2015 · Gastrointestinal endoscopy
  • Yu-Chun Chang · Wu-Chia Lo · Cheng-Yu Lo · Li-Jen Liao
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    ABSTRACT: Cervical cystic lymph node metastasis as the first and sole manifestation of occult papillary thyroid carcinoma (PTC) is uncommon, and can be mistaken for branchial cleft cyst. The present study reports two cases of PTC initially presenting as upper lateral neck cysts. Ultrasound examination confirmed the presence of occult papillary carcinoma with neck metastasis. The critical importance of ultrasound examination of the soft tissue of the neck for the identification of the clinical manifestations and the imaging features of occult PTC are discussed, with an emphasis on factors that may contribute to misdiagnosis.
    No preview · Article · Jun 2013 · Journal of Medical Ultrasound
  • Chung-Tsui Huang · Cheng-Yu Lo · Tzong-Hsi Lee
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    ABSTRACT: Peripancreatic lymph node is a rare site for extrapulmonary tuberculosis involvement(1) . The presentation is usually indolent with weight loss, abdominal pain, fever or obstructive jaundice.(2-4) Besides, the enlarged lymph node resembles pancreatic parenchyma on ultrasound or computed tomography (CT) due to similar tissue density.(5-7) Therefore, it is often misdiagnosed as pancreatic malignancy.(8,9) Imaging modality with higher accuracy and tissue proof are mandatory for diagnosis and further management.(10,11).
    No preview · Article · Nov 2012 · Journal of Digestive Diseases
  • Pei-San Chia · Cheung Leung · Yu-Ling Hsu · Cheng-Yu Lo
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    ABSTRACT: Transient neonatal pustular melanosis is mostly found in full-term black infants. It is a benign and self-limited disease, and the etiology is still unknown. We present a full-term female neonate with multiple vesiculopustular and pigmented macular lesions found immediately after her birth. A skin biopsy showed vesicles consisting of intracorneal and subcorneal aggregates of neutrophils, which is compatible with transient neonatal pustular melanosis. Although it is rare in Taiwan and Asian countries, transient neonatal pustular melanosis should always be considered when pustulosis is found in the neonatal period to prevent the use of unnecessary antibiotics. Dermatological consultation and histological confirmation are sometimes required for the final diagnosis.
    No preview · Article · Dec 2010 · Pediatrics & Neonatology
  • Yi-Lun Tseng · Yu-Chin Lin · Cheng-Yu Lo · Li-Jen Liao
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    ABSTRACT: We report a case of subglottic narrowing caused by an extranodal deposit of sinus histiocytosis in a 55-year-old man. To the best of our knowledge, no previous reports have described diagnosis using sonographic-guided fine-needle aspiration cytology for Rosai-Dorfman disease of the subglottis. This patient was diagnosed by sonographic-guided fine-needle aspiration biopsy, which revealed lymphocytes, plasma cells, and many foamy, multinuclear histiocytes with preserved lymphocytes in their cytoplasm (emperipolesis). The patient underwent an incisional biopsy of the tumor and received postoperative steroids and low-dose chemotherapy. The subglottic tumor was markedly regressed 6 months later.
    No preview · Article · Jan 2009 · Journal of Clinical Ultrasound
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    ABSTRACT: Intravascular papillary endothelial hyperplasia (IPEH) is an abundant, usually intravascular, benign endothelial proliferation that may mimic angiosarcoma clinically and histopathologically. Its occurrence in the sinonasal cavity is extremely rare. To the best of our knowledge, we present the first case with the most extensive IPEH ever found within the sinonasal cavity. A 42-year-old man of intravascular papillary endothelial hyperplasia in the sinonasal cavity was reported. He complained of a 1-year history of left-sided nasal obstruction accompanied by unilateral rhinorrhea, repeated epistaxes and frontal headache. Anterior rhinoscopy demonstrated a smooth-surfaced reddish mass occupying the left nasal cavity. Endoscopic surgery was used to clear this uncommon tumor in the sinonasal cavity. A review of the pertinent literature was also presented. IPEH may be mistaken for an angiosarcoma clinically and histopathologically. Complete endoscope-guided surgical excision is the best choice of therapy for patients with IPEH and is both diagnostic and curative. Awareness of this lesion will prevent incorrect diagnosis and overly aggressive treatment.
    No preview · Article · Oct 2008 · Auris, nasus, larynx
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    ABSTRACT: Parotitis caused by nontuberculous mycobacteria, a very rare disease entity, has never been reported to be caused by Mycobacterium fortuitum (M. fortuitum) in the literature. An 8-year-old girl was seen with painful swelling of the right parotid gland despite antibiotic treatment of more than 1 month. Elevated serum amylase activity and diffuse contrast-enhanced CT of the parotid gland confirmed the diagnosis of parotitis. Histopathological study of specimens taken from the right parotid tail mass showed granulomatous inflammation with acid-fast positive bacilli; culture later confirmed M. fortuitum. After administration of clarithromycin and ciprofloxacin for 9 consecutive months, the parotitis and parotid tail mass were completely resolved at follow-up examination. To our knowledge, this is the first case report of parotitis caused by M. fortuitum and its successful medical treatment.
    Preview · Article · Nov 2007 · Head & Neck
  • Shu-Chin Chien · Cheng-Yu Lo · Ming-Chow Wei

    No preview · Article · Oct 2007 · Taiwanese journal of obstetrics & gynecology
  • Chia-Hung Chen · Cheng-Yu Lo

    No preview · Article · Dec 2006 · Archives of Otolaryngology - Head and Neck Surgery