Are you Karl Erik Jensen?

Claim your profile

Publications (4)6.34 Total impact


  • No preview · Article · Oct 2015
  • Lars Remvig · Karl Erik Jensen

    No preview · Article · Mar 2011 · International Musculoskeletal Medicine
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: It is generally recommended that conservative treatment for atlanto-axial subluxation (AARS) is abandoned, in favour of surgical spondylodesis, 3 months after an incident leading to the condition. However, where bony deformation has occurred and this is in a growing individual, bony re-modelling is known to take place and a chance of normalizing bony deformation and consequently of correcting head position and movement still exists. The purpose of this study is to present a hitherto undescribed bony deformation as a possible background for persistent AARS and to illustrate the re-modelling of the deformation through conservative treatment.Patient and methods: The patient was treated in the in-patient clinic for 14 days with Gartner traction and manual therapy, then with out-patient treatment for 16 weeks. For the first 8 weeks, she wore a rigid cervical orthosis constantly and also had manual therapy 3 times weekly. During the following 8 weeks, the orthosis was slowly exchanged for a soft collar, the use of which was reduced through the period and then stopped. In the same period, the frequency of manual treatment was likewise gradually reduced in favour of home exercises. A single Botox (botunlinum toxin) injection was given approximately half-way through the out-patient treatment period.Results: During the out-patient period, active cervical rotation to the right was increased from 45? to 70?, and extension from 15? to 90?. At 1-year follow-up, active cervical movements were: rotation right/left: 65?/80?, extension: 90?, and control MRI-scan indicated normalisation of the bony deformation.Conclusions: The clinical result shows that conservative treatment can still be effective even after 6 months' persistence of the Cock-Robin position. Furthermore, the results of the CT- and MRI-scans indicate that re-modelling of a bony deformation of the lateral mass of C2 occurs even 6 months after an incident leading to AARS. Further studies are needed in order to make a general recommendation of this treatment in long-lasting cases of AARS before surgery is considered.Background: It is generally recommended that conservative treatment for atlanto-axial subluxation (AARS) is abandoned, in favour of surgical spondylodesis, 3 months after an incident leading to the condition. However, where bony deformation has occurred and this is in a growing individual, bony re-modelling is known to take place and a chance of normalizing bony deformation and consequently of correcting head position and movement still exists. The purpose of this study is to present a hitherto undescribed bony deformation as a possible background for persistent AARS and to illustrate the re-modelling of the deformation through conservative treatment.Patient and methods: The patient was treated in the in-patient clinic for 14 days with Gartner traction and manual therapy, then with out-patient treatment for 16 weeks. For the first 8 weeks, she wore a rigid cervical orthosis constantly and also had manual therapy 3 times weekly. During the following 8 weeks, the orthosis was slowly exchanged for a soft collar, the use of which was reduced through the period and then stopped. In the same period, the frequency of manual treatment was likewise gradually reduced in favour of home exercises. A single Botox (botunlinum toxin) injection was given approximately half-way through the out-patient treatment period.Results: During the out-patient period, active cervical rotation to the right was increased from 45? to 70?, and extension from 15? to 90?. At 1-year follow-up, active cervical movements were: rotation right/left: 65?/80?, extension: 90?, and control MRI-scan indicated normalisation of the bony deformation.Conclusions: The clinical result shows that conservative treatment can still be effective even after 6 months' persistence of the Cock-Robin position. Furthermore, the results of the CT- and MRI-scans indicate that re-modelling of a bony deformation of the lateral mass of C2 occurs even 6 months after an incident leading to AARS. Further studies are needed in order to make a general recommendation of this treatment in long-lasting cases of AARS before surgery is considered.
    No preview · Article · Jun 2008 · International Musculoskeletal Medicine
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The Pierre Robin sequence (PRS), consisting of cleft palate, micrognathia and glossoptosis, can be seen as part of the phenotype in other Mendelian syndromes--for instance, campomelic dysplasia (CD) which is caused by SOX9 mutations--but the aetiology of non-syndromic PRS has not yet been unravelled. To gain more insight into the aetiology of PRS by studying patients with PRS using genetic and cytogenetic methods. 10 unrelated patients with PRS were investigated by chromosome analyses and bacterial artificial chromosome arrays. A balanced translocation was found in one patient, and the breakpoints were mapped with fluorescence in situ hybridisation and Southern blot analysis. All patients were screened for SOX9 and KCNJ2 mutations, and in five of the patients expression analysis of SOX9 and KCNJ2 was carried out by quantitative real-time PCR. An abnormal balanced karyotype 46,XX, t(2;17)(q23.3;q24.3) was identified in one patient with PRS and the 17q breakpoint was mapped to 1.13 Mb upstream of the transcription factor SOX9 and 800 kb downstream of the gene KCNJ2. Furthermore, a significantly reduced SOX9 and KCNJ2 mRNA expression was observed in patients with PRS. Our findings suggest that non-syndromic PRS may be caused by both SOX9 and KCNJ2 dysregulation.
    Full-text · Article · Jul 2007 · Journal of Medical Genetics