[Show abstract][Hide abstract] ABSTRACT: Background/Aim: Bone alkaline phosphatase (bAP) is known to be an important biochemical marker of bone formation. Through the present study, we intended to find out whether there is any advantage in bAP determination, as a routine biochemical marker, besides intact parathyroid hormone (iPTH) in hemodialysis patients. Methods: In a population of 140 hemodialysis patients, bAP and iPTH were determined on four quarterly consecutive occasions. According to the values of iPTH (pg/ml) and bAP (ng/ml), patients were divided into four groups: group I: iPTH >200 and bAP >20, group II: iPTH >200 and bAP 20. Patients with higher serum phosphorus (P) (group A: p ≧7 mg/dl) were compared with those with lower serum P levels (group B: p Results: The global correlation between iPTH and bAP (total evaluations, n = 503) was 0.32 (p Conclusion: Although iPTH and bAP are frequently in agreement, it seems important to separate parathyroid activity given by iPTH, from bone remodelling reflected by bAP, in the presence of either a higher aluminum exposition or a well-controlled phosphatemia.
Full-text · Article · Feb 2005 · Nephron Clinical Practice