[Show abstract][Hide abstract]ABSTRACT: A guided medical propulsion capsule driven by strong electro-magnetic interaction between an external AC/DC magnetic gradient-lobe generator and a set of uniquely magnetized ferrous-conductive elements contained within the capsule. The capsule is navigated through the lumens and cavities of the human body wirelessly and without any physical contact for medical diagnostic, drug delivery, or other procedures with the magnetically guiding field generator external to the human body. The capsule is equipped with at least two sets of magnetic rings, disks and/or plates each possessing anisotropic magnetic properties. The external magnetic gradient fields provide the gradient forces and rotational torques on the internal conductive and magnetic elements needed to make the capsule move, tilt, and rotate in the body lumens and cavities according to the commands of an operator.
[Show abstract][Hide abstract]ABSTRACT: A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.
[Show abstract][Hide abstract]ABSTRACT: Wireless embedded platforms play a significant role in Wireless Health: For many hidden medical conditions, symptoms may not reveal during traditional clinical visits. Cumulative, free-living monitoring, where individuals are monitored continuously with the use of wireless electronics and sensors, is considered a potential solution for capturing additional physiological data (Bonato 2003). From chronic disease management to physical rehabilitation, these platforms have demonstrated their potential uses (Moy et al. 2003; Bonato 2005).
[Show abstract][Hide abstract]ABSTRACT: Virtual proprioception is a novel device for providing near autonomous biofeedback of hemiparetic gait disparity in real time. With virtual proprioception a user may modify gait dynamics to develop a more suitable gait in tandem with real time feedback. Accelerometers are fundamental to the operation of the device, and a thorough consideration of the accelerometry technology space for locomotion quantification is included. The role of traumatic brain injury and respective decrements to gait quality and proprioceptive feedback are addressed. Virtual proprioception conceptual test and evaluation yielded positive results. The active 'on' status of the virtual proprioception biofeedback for alternative gait strategy was bounded by a 90% confidence level with a 10% margin of error.
Article · Feb 2008 · Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
[Show abstract][Hide abstract]ABSTRACT: Falls are currently a leading cause of death from injury in the elderly. The usage of conventional assistive cane devices is critical in reducing the risk of falls and is relied upon by over 4 million patients in the U.S. While canes provide physical support as well as supplementary sensing feedback to pa-tients, at the same time, these conventional aids also exhibit serious adverse effects that contribute to falls. The falls due to the improper usage of the canes are particularly acute in the elderly and disabled where reduced cognitive capacity accompanied by the burden of managing cane motion leads to increased risk. This paper describes the development of the SmartCane assistive system that encompasses broad en-gineering challenges that will impact general development of individualized, robust assistive and prosthetic devices. The SmartCane system combines advances in signal processing, embedded computing, and wireless networking technology to provide capabilities for remote monitoring, local signal processing, and real-time feedback on the cane usage. This system aims to reduce risks of injuries and falls by enabling training and guidance of patients in proper usage of assistive devices.
[Show abstract][Hide abstract]ABSTRACT: Using a large consortium of undergraduate students in an organized program at the University of California, Los Angeles (UCLA), we have undertaken a functional genomic screen in the Drosophila eye. In addition to the educational value of discovery-based learning, this article presents the first comprehensive genomewide analysis of essential genes involved in eye development. The data reveal the surprising result that the X chromosome has almost twice the frequency of essential genes involved in eye development as that found on the autosomes.
Full-text available · Article · Nov 2007 · Genetics
[Show abstract][Hide abstract]ABSTRACT: How can you combine professional-quality research with discovery-based undergraduate education? The UCLA Undergraduate Consortium for Functional Genomics provides the answer.
Full-text available · Article · Mar 2005 · PLoS Biology