I. Paclt

Charles University in Prague, Praha, Praha, Czech Republic

Are you I. Paclt?

Claim your profile

Publications (51)42.36 Total impact

  • Source
    R Ptácek · H Kuzelová · I Paclt · I Zukov · S Fischer
    [Show abstract] [Hide abstract]
    ABSTRACT: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed childhood psychiatric disorders and it constitutes a group of developmental disorders, which are characterized by inadequate level of attention, excessive activity and impulsivity. In connection with neurological and endocrinological changes, children with ADHD can show also changes in the growth and development without consequence to the medication. Differences were found especially in higher weight and BMI. Very few studies were done on this topic and the results of the studies are very different, methods are heterogeneous and insufficient. The most serious absence is the much reduced number of anthropometrics and other characteristics and parameters. Studies usually analyse only BMI, height and weight and do not take into account socio-economic characteristics, feeding customs and other important factors. Many studies are done on changes in growth only associated with medical treatment of children ADHD. However changes in the development and growth can be a manifestation of the disorder itself. Authors of this paper review studies which monitor changes in the development of children with ADHD and compare their results.
    Full-text · Article · Feb 2009 · Prague medical report
  • [Show abstract] [Hide abstract]
    ABSTRACT: The study compares differences in parameters between the group of boys with ADHD which used Ritalin medication and the group which did not. The results of the study significantly show the difference in anthropometrics characteristics between these two groups, especially significant difference is in the signs of nutrition (% fat, BMI). Children using medication have lower percentage of body fat and lower BMI. These results are in correspondence with other studies.
    No preview · Article · Jan 2009
  • M. Kopečková · I. Paclt · P. Goetz

    No preview · Article · Jan 2008
  • R. Ptáček · H. Kuželová · I. Paclt · I. Žukov
    [Show abstract] [Hide abstract]
    ABSTRACT: The study compares differences in parameters between the group of boys with diagnosis ADHD which used Ritalin medication and the group which did not. The results of the study significantly show the difference in anthropometric characteristics between these two groups, especially significant difference is in the signs of nutrition (% fat, BMI). Children using medication have lower percentage of body fat and lower BMI. These results are in correspondence with other studies.
    No preview · Article · Jan 2008
  • [Show abstract] [Hide abstract]
    ABSTRACT: ADHD (attention hyperactivity disorder) is a polygenetic disorder with various candidate genes. At this time, more than thirty dopaminergic, noradrenergic, serotonergic and GABA-ergic genes are known. The research of only some candidate genes (DRD4, DAT, DRD5, DBH, 5HTT, HTR1B and SNAP25) brought relatively consistent results confirming the heredity of ADHD syndromes. The results of research of other genes (DRD2, DRD3, MAO, ADR2A, GABA A3, GABA B3) are not clear yet. This paper summarizes the most important genetic data in correlations with biochemical periphery parameters (especially for DBH, HVA, MHPG, serotonin). Hypothetically, certain subgroups of ADHD may be identified by correlation of biochemical characteristics and some candidate genes. The paper discusses some implications for future research. Review.
    No preview · Chapter · Jan 2007
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Chronic tinnitus is a frequent and often severely disabling disorder with a prevalence of over 8% in subjects over 50 years. Tinnitus disrupts the full-value life of the patient and it is difficult to treat. The disorder is frequently associated with hearing loss and may be the result of neuroplastic alterations within the brain. Neuroimaging studies demonstrate increased activity within the central auditory system. TMS is a non-invasive method uses electromagnetic principles. TMS allows to modulate the excitability within superficial cortical areas. Stimulation effects can propagate also to functionally connected remote brain areas. It has been successfully employed in the treatment of other conditions associated with increased activity of the cerebral cortex. Applied as low frequency rTMS it has been proven to be effective for the treatment of disorders which are associated with focal hyperexcitability such as auditory hallucinations. There is a good theoretical basis and increasing research evidence suggesting a potential of TMS for the treatment of tinnitus. Further studies with large sample sizes and additional assessment of neurobiological effects are needed. Within this paper we discuss the potential for TMS as a therapy of tinnitus.
    Full-text · Article · Jan 2007 · Ceska a Slovenska Neurologie a Neurochirurgie
  • Source
    M Kopecková · I Paclt · P Goetz
    [Show abstract] [Hide abstract]
    ABSTRACT: ADHD is a multifactorial disorder clinically characterized by inattentiveness, impulsivity and hyperactivity. The occurrence of this disorder varies between 3 and 6% of the child population, with boys predominating over girls at a ratio of 3 : 1 or more. Dysfunction or imbalance between the dopaminergic and noradrenergic systems of neurotransmitters can play a key role in the ADHD pathophysiology. Alteration of the dopamine/noradrenaline levels can result in hyperactivity. DBH is an enzyme responsible for the conversion of dopamine into noradrenaline. The DBH protein is released in response to stimulation. DBH activity, derived largely from sympathetic nerves, can be measured in human plasma. Patients with ADHD showed decreased activities of DBH in serum and urine. Low DBH levels correlate indirectly with the seriousness of the hyperkinetic syndrome in children (Galvin et al., 1995, 1997). In the DBH gene, the G444A, G910T, C1603T, C1912T, C-1021T, 5'-ins/del and TaqI polymorphisms occur frequently and may affect the function of gene products or modify gene expression and thus influence the progression of ADHD. This article reviews the DBH itself and polymorphisms in the DBH gene that influence the DBH activity in the serum and the CSF level of DBH. All those are evaluated in connection with ADHD.
    Full-text · Article · Feb 2006 · Folia biologica
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: We tested the hypothesis considering the role of hypothalamic-pituitary-thyroid axis (HPT), L-triiodothyronine (L-T3) uptake into erythrocytes, and the role of membrane lipids in the development and treatment of affective disorders. Changes in kinetic parameters (V(max), maximal velocity and K(M), apparent Michaelis constant) of L-T3 uptake into red blood cells (RBCs) and changes in membrane fluidity in a group of 24 patients with major depression were measured before treatment and after 1 month of treatment with citalopram. Parameters V(max) and K(M), as well as membrane microviscosity, were significantly increased in depressed patients both before and after treatment in comparison with healthy subjects. We concluded that the function of the membrane transporter for L-T3 in RBC is changed in depression. This change is probably connected with alteration of membrane fluidity and/or transporter-lipid interactions. We did not find any normalization of the measured parameters after 1 month of treatment. The results show the importance of composition and physical properties of the lipid bilayer for transmembrane transport of L-T3 and support the hypothesis that the HPT axis is in depression.
    Full-text · Article · Feb 2006 · Physiological research / Academia Scientiarum Bohemoslovaca
  • Radek Ptacek · Petr Bob · Ivo Paclt
    [Show abstract] [Hide abstract]
    ABSTRACT: Psychometric properties of the Czech version of Dissociative Experiences Scale were tested from the viewpoint of internal consistency, validity and factor structure using data from adult persons (n = 783) divided into three groups (epilepsy n = 243, depression n = 357, norm n = 183), average age 39 years, SD = 13,5. Findings showed that reliability, validity and factor structure is corresponding with the original English version. The Czech version of the questionnaire may be considered as suitable for estimation of subjectively experienced dissociative symptoms.
    No preview · Article · Jan 2006 · Ceskoslovenská psychologie
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: ADHD (attention hyperactivity disorder) is a polygenetic disorder with various candidate genes. At this time, more than thirty dopaminergic, noradrenergic, serotonergic and GABA-ergic genes are known. The research of only some candidate genes (DRD4, DAT, DRD5, DBH, 5HTT, HTR1B and SNAP25) brought relatively consistent results confirming the heredity of ADHD syndromes. The results of research of other genes (DRD2, DRD3, MAO, ADR2A, GABA A3, GABA B3) are not clear yet. This paper summarizes the most important genetic data in correlations with biochemical periphery parameters (especially for DBH, HVA, MHPG, serotonin). Hypothetically, certain subgroups of ADHD may be identified by correlation of biochemical characteristics and some candidate genes. The paper discusses some implications for future research. Review.
    Full-text · Article · Sep 2005 · Neuro endocrinology letters

  • No preview · Article · Mar 2005 · European Neuropsychopharmacology

  • No preview · Conference Paper · Jan 2005
  • P. Bob · R. Ptacek · J. Pavlat · D. Jasova · I. Paclt · P. Zvolsky · M. Pav
    [Show abstract] [Hide abstract]
    ABSTRACT: Characteristic psychopathological symptoms observed in patients with complex partial epilepsy may emerge also without any typical motor manifestations that occur in epilepsy. These nonconvulsive epileptic symptoms may produce cognitive, affective or psychosensoric symptoms called complex partial seizure-like symptoms. Complex partial seizure-like symptoms are observed to be in close relationship to increased sensitivity on parental influence and dissociative tendency due to traumatic or aversive events most often in connection to child abuse with good response to anticonvulsant drugs. In this study were assessed complex partial seizure-like symptoms and their relationship to other psychopathological symptoms (childhood trauma, stress, dissociation and depression) using Structured Clinical Interview for Complex Partial Seizure-like Symptoms, Dissociative Experiences Scale (DES), Somatoform Dissociation Questionnaire (SDQ-20), Impact of Events Scale (IES), Beck Depression Inventory (BDI-II) and Trauma Symptoms Checklist (TSC-40). These data show that 20% from 100 investigated depressed patients have high values of complex partial seizure-like symptoms and satisfy the criteria for epilepsy spectrum disorder. These patients are significantly dissociated, distressed and traumatized and meet the criteria for posttraumatic stress disorder. With respect to the evidence that depressive symptoms may be produced by epileptic activity these pathological characteristics can be useful for pre-treatment prediction for anticonvulsant treatment.
    No preview · Article · Jul 2004
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the study was to detect the changes of QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and vectorcardiographic recordings were obtained using Cardiag 112.2 diagnostic system from 28 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From these recordings following parameters were evaluated: QTd, spatial QRS-STT angle and amplitude of T-wave. The acquired data were correlated with the dosulepin plasma levels using Spearman's rank order correlation test. The average QTd (+/-S.D.) in the dosulepin group was significantly higher (70+/-21 ms) than that in the control group (34+/-12 ms) (P<0.001). Moreover, the correlation between QTd and the dosulepin plasma levels was highly significant (r = 0.7871, P<0.001). Similar results were obtained when QTc dispersion was used. On the contrary, the QRS-STT space angle did not correlate with the dosulepin plasma levels. Furthermore, the T-wave amplitude was not significantly correlated to the QT-interval. Thus we can conclude that the QT dispersion could be used as a simple marker of the dosulepin effect on the myocardium.
    Preview · Article · Feb 2004 · Physiological research / Academia Scientiarum Bohemoslovaca
  • Source
    I Paclt · J Koudelová
    [Show abstract] [Hide abstract]
    ABSTRACT: In children and adolescents (250 healthy subjects) serum dopamine-beta-hydroxylase (DBH) activity (23.9+/-5.2 to 57.1+/-17.5 micromol/min/ml) increases with the age between 3-10 years, later it decreases approximately by the age of 10-14 years. At the age of 21 to 60 years DBH level is stable. Our study described decreasing DBH activity in adolescents at the age of 10-14 years in the studied sample of healthy persons. Experimental animals (200 Wistar rats, 5-120 days old) show the same trend of enzymatic activity, similarly as in humans. DBH activity in rats is between 0.85+/-0.1 to 2.8+/-0.05 micromol/min/ml. This activity is highest in 5-day-old rats; it decreases till the age of 14 days and increases mainly in 14- to 35-day-old animals. Decrease of DBH activity in rats between 35 to 40 days is significant and corresponds to the reduction of DBH activity in adolescent humans (10-14 years). Adult rats (aged 90-120 days) show a stable DBH activity. DBH activity intermediately decreases in 10- to 14-year-old children. This decrease corresponds to the intermediate developmental changes of electrophysiological parameters (decreasing EEG activity in healthy adolescents occurs in 10-14 years old children). Puberty is coupled with intermediate decreasing of DBH activity in man and also in experimental animals in the period of prominent psychological and physiological changes.
    Preview · Article · Feb 2004 · Physiological research / Academia Scientiarum Bohemoslovaca
  • [Show abstract] [Hide abstract]
    ABSTRACT: The cardio-toxic effects of therapeutic plasma levels of TCA (150-200 ng/ml in serum) are not quite so evident. New information about it bring the device of Cardiag 112.2, which can measure simultaneously the ECG (electrocardiography) , VCG (vectorcardiography) and BSPM (method of body surface potential mapping). With this device we made 2 studies. In the first one, we tried to prove if in depressive patients in remission, treated with prophylactic doses of dosulepine, are some statistically significant changes in ECG parameters in dependence with dosulepine plasma levels. 4 electrocardiological parameters were proven to correlate significantly with dosulepine plasma levels: QRS axis deviation in frontal plane (by the method of VCG) (p < 0,01), the maximal positive value of the isointegral map during the first 40 ms of the QRS complex, the so called DIAM40max (by the method of BSPM) (p < 0,05) and QRS-STT vectors plane angles in transversal and in left sagittal planes (by the method of VCG) (p < 0,05). In the second one, we measured the dispersion of QT interval in depressive patients treated with dosulepine (by the method of BSPM) and than we correlated the QTd with dosulepine plasma levels. It was suggested as was by many authors, that dispersion of the QT interval (QTd) is a non specific sign of a changed course of repolarization, which reflects the cardiotoxic side effects of dosulepin and that it could be used also as a simple marker for the elevated plasma level of dosulepin on the myocardium at therapeutic or prophylactic plasma levels. The antidepressant of dosulepine is potentially dangerous in inducing of the cardiac arrhytmias in depressive patients without cardiac diseases, and this cardiovascular risk is in the correlation with dosulepine plasma levels.
    No preview · Article · Jan 2004
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the study was to detect changes of the QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and body surface potential mapping (BSPM) recordings were obtained using Cardiag 112.2 diagnostic system from 27 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From these recordings the QTd and the dispersion of heart rate-corrected QT interval QTc were evaluated. These parameters were estimated both from 80 BSPM leads and from 12 standard ECG leads. Acquired data were statistically correlated by Spearman rank order correlation coefficient with dosulepin plasma levels. The average QTd evaluated from BSPM leads (+/-SD) in the dosulepin group was significantly higher [70 (+/-21) ms] than that in the control group [34 (+/-12) ms] (P< 0.001). Moreover, the correlation between QTd and the dosulepin plasma level was statistically significant as well (P< 0.001) with the value of correlation coefficient 0.7871. The QTd evaluated from standard 12 ECG leads was increased in dosulepin group as well [46 (+/-18) ms vs. 28 (+/-10) ms - P< 0.05] but we have not found any significant correlation of the QTd with the dosulepin plasma level. According to the above-mentioned results we can conclude that the QTd estimated from BSPM leads (but not that estimated from 12-lead ECG) could be used as a marker of the dosulepin effect on the myocardium.
    Preview · Article · Jan 2004 · Prague medical report
  • L. Stárková · Z. Fisar · I. Paclt · J. Vevera

    No preview · Article · Oct 2003 · European Neuropsychopharmacology
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Tricyclic antidepressant drugs dosulepine (TCA), serotonin selective reuptake inhibitor (SSRI) and prophylactic agent with antidepressant effect lithium carbonicum (Li) have different cardiovascular side-effects. We compared them in the prophylactic therapy of periodic affective disorder in remission with TCA, SSRI and Li. Our previous papers confirmed the most prominent effects of heart electric field parameters in TCA patients (Slavícek et al., 1998). In the present work we studied for the first time the dose-dependent changes of ECG, body surface potential maps (BSPM - parameter DIAM 30, 40) in 43 TCA dosulepine, 40 SSRI citalopram and 30 Li outpatients (Hamilton scale: HAMDŁ10; age 40+/-5 years; treated for depressive disorders or bipolar disorders). The daily doses of dosulepine were 50-250 mg, citalopram 20-80 mg, Li plasma levels 0.66+/-0.08 meq/l. The electrocardiogram (ECG), vectorcardiogram (VCG), and BSPM were measured and calculated by the Cardiag 112.1 diagnostic system. The results have shown a relation between the dose of dosulepine and extremum (maximum and minimum) of depolarization isoarea map in dosulepine, but not in citalopram patients. The repolarization BSPM changes were most pronounced in SSRI patients. Lithium in long-term prophylaxy (1-22 years) caused only minimal ECG BSPM changes. The present results correspond with our previous observations.
    Preview · Article · Feb 2003 · Physiological research / Academia Scientiarum Bohemoslovaca
  • [Show abstract] [Hide abstract]
    ABSTRACT: The purpose of the study was to compare psychopathological processes in depressed patients in the wider framework of relationships of psychopathological and somatoform symptoms. 102 depressed patients with ICD-10 diagnoses were investigated by psychological testing of psychic dissociation (using Dissociative Experiences Scale - DES) and somatoform dissociation (Somato-form Dissociation Questionnaire-SDQ-20), stress and PTSD (Impact of Event Scale-IES), childhood traumas (Trauma Symptoms Checklist-TSC-40, depression (Beck Depression Inventory-BDI-II) and complex partial seizure-like symptoms (Structured Interview for Complex Partial Seizure-like Symptoms-used abbreviation CPSI). The results show that the median DES score in all depressed subjects is 12. 18 depressed patients (17.6%) meet the criteria for dissociative disorders (DES≥25), 32 (31.37 %) patients satisfy the criteria for somatoform dissociative disorders (SDQ-20≥40), 20 (19.6 %) patients meet the criteria for epilepsy spectrum disorders (CPSI≥70) and 49 (48.03 %) meet criteria for major depression (BDI-II≥30). These patients are also significantly distressed and traumatized. A significant correlation 0.79 (p<0.01) between complex partial seizure-like symptoms (CPSI) and somatoform dissociation (SDQ-20) was found. An other significant correlation 0.61 (p<0.01) was found between SDQ-20 and total TSC-40 and 0.65 (p<0.01) between SDQ-20 and subscale for dissociation in TSC-40. In depressed patients there are two important distinct sub-groups. The first includes 18 patients satisfying criteria for dissociative disorders (DES≥25) but these patients have a lower median for somatoform dissociation and complex partial seizure-like symptoms than in the whole group of patients. The second sub-group includes 32 patients with high somatoform dissociation (SDQ-20≥40) but it has a lower median of psychic dissociation (DES) than in the whole group of patients. Somatoform dissociation and complex partial seizure-like symptoms in depressed patients are significantly correlated (0.79, p<0,01). Somatoform and psychic dissociative symptoms in these patients show a complementary character. Lowering of psychic dissociation with regard to the median of all patients is couplet to increasing somatoform dissociation and vice versa.
    No preview · Article · Jan 2003