Mariza Polati

University of São Paulo, San Paulo, São Paulo, Brazil

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Publications (22)9.35 Total impact

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    ABSTRACT: Purpose: To assess the sociodemographic profiles, teratogen exposures, and ocular congenital abnormalities in Brazilian patients with Möbius sequence. Method: Forty-four patients were recruited from the Brazilian Möbius Sequence Society. This cross-section comprised 41 patients (age, mean ± standard deviation, 9.0 ± 5.5 years) who fulfilled the inclusion criteria. The parent or caregiver answered a questionnaire regarding sociodemographic data and pregnancy history. Patients underwent ophthalmological assessments. They were subdivided into groups according to misoprostol exposure during pregnancy, and the two groups were compared. Results: Mothers/caregivers reported unplanned pregnancies in 36 (88%) cases. Of these, 19 (53%) used misoprostol during their first trimesters. A stable marital status tended to be more frequent in the unexposed group (P=0.051). Incomplete elementary school education was reported by two (11%) mothers in the exposed group and by three (14%) mothers in the unexposed group (P=0.538). The mothers' gestational exposures to cocaine, marijuana, alcohol, and cigarettes were similar in both groups (P=0.297, P=0.297, P=0.428, and P=0.444, respectively). One (5%) case of Rubella infection during pregnancy was found in the unexposed group. The main malformations in the exposed and unexposed groups were the following: strabismus (72% and 77%, respectively), lack of emotional tearing (47% and 36%, respectively), and lagophthalmos (32% and 41%, respectively). Conclusion: Stable marital statuses tended to be more frequent among mothers that did not take misoprostol during pregnancy. Exposures to other teratogens and the main ocular abnormalities were similar in both groups.
    No preview · Article · Oct 2014 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: To assess the prevalence of refractive errors in Möbius sequence. This study was carried out during the Annual Meeting of the Brazilian Möbius Society in November 2008. Forty-four patients diagnosed with the Möbius sequence were submitted to a comprehensive assessment, on the following specialties: ophthalmology, neurology, genetics, psychiatry, psychology and dentistry. Forty-three patients were cooperative and able to undertake the ophthalmological examination. Twenty-two (51.2 %) were male and 21 (48.8%) were female. The average age was 8.3 years (from 2 to 17 years). The visual acuity was evaluated using a retro-illuminated logMAR chart in cooperative patients. All children were submitted to exams on ocular motility, cyclopegic refraction, and fundus examination. From the total of 85 eyes, using the spherical equivalent, the major of the eyes (57.6%) were emmetropics (>-0.50 D and <+2.00 D). The prevalence of astigmatism greater than or equal to 0.75 D was 40%. The prevalence of refractive errors, by the spherical equivalent, was 42.4% in this studied group.
    Full-text · Article · Aug 2013 · Arquivos brasileiros de oftalmologia
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    ABSTRACT: Saethre-Chotzen syndrome is a very rare congenital syndrome characterized by craniosynostosis. The incidence of it is around 1: 50,000 live births. Intelligence is usually normal, but a few affected individuals may have mild to moderate mental retardation. Children with Saethre-Chotzen syndrome should be evaluated by members of an experienced interdisciplinary team as treatment usually involves many different specialities. The strabismus surgery in these patients is difficult, because they usually have anomalous insertion and misdirection of the extraocular muscles. Imaging techniques are recommended in order to investigate the anatomical aspects of the extraocular muscles and their insertions.
    Full-text · Article · Jun 2013 · Revista brasileira de oftalmologia

  • No preview · Article · Feb 2013 · Arquivos de neuro-psiquiatria
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    ABSTRACT: To investigate the contribution of the individual ocular components, i.e. anterior chamber depth, lens thickness and vitreous chamber depth, to total axial length in patients with esotropic amblyopia. The study population consisted of 74 children, aged between 5 and 8 years: thirty-seven patients with esotropic amblyopia and 37 healthy volunteers (control group). The participants underwent a comprehensive ophthalmological examination, including cycloplegic refraction and A-scan ultrasonography. Anterior chamber depth, lens thickness, vitreous chamber depth and total axial length were recorded. Paired Student's t-tests were used to compare biometric measurements between amblyopic eyes and their fellow eyes and between right and left eyes in the control group. To evaluate the contribution of the ocular components to the total axial length, we report the individual components as a percentage of total axial length. The comparison between amblyopic and fellow eyes regarding the individual contribution from ocular components to the total axial length revealed greater contribution from lens thickness (P=0.001) and smaller contribution from vitreous chamber depth (P=0.001) in amblyopic eyes, despite similar contribution from anterior chamber depth (P=0.434). The comparison between right and left eyes in the control group showed similar contributions from anterior chamber depth (P=0.620), lens thickness (P=0.721), and vitreous chamber depth (P=0.483). This study shows differences between amblyopic and non-amblyopic eyes when the total axial length is broken down into the individual contribution from the ocular components.
    Full-text · Article · Feb 2012 · Arquivos brasileiros de oftalmologia
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    ABSTRACT: To study the oculometric parameters of hyperopia in children with esotropic amblyopia, comparing amblyopic eyes with fellow eyes. Thirty-seven patients (5-8 years old) with bilateral hyperopia and esotropic amblyopia underwent a comprehensive ophthalmic examination, including cycloplegic refraction, keratometry and A-scan ultrasonography. Anterior chamber depth, lens thickness, vitreous chamber depth and total axial length were recorded. The refractive power of the crystalline lens was calculated using Bennett's equations. Paired Student's t-tests were used to compare ocular biometric measurements between amblyopic eyes and their fellow eyes. The associations of biometric parameters with refractive errors were assessed using Pearson correlation coefficients and linear regression. Multivariable models including axial length, corneal power and lens power were also constructed. Amblyopic eyes were found to have significantly more hyperopic refraction, less corneal power, greater lens power, shorter vitreous chamber depth and shorter axial length, despite similar anterior chamber depth and lens thickness. The strongest correlation with refractive error was observed for the axial length/corneal radius ratio (r(36) = -0.92, p < 0.001 for amblyopic and r(36) = -0.87, p < 0.001 for fellow eyes). Axial length accounted for 39.2% (R(2)) of the refractive error variance in amblyopic eyes and 35.5% in fellow eyes. Adding corneal power to the model increased R(2) to 85.7% and 79.6%, respectively. A statistically significant correlation was found between axial length and corneal power, indicating decreasing corneal power with increasing axial length, and they were similar for amblyopic eyes (r(36) = -0.53, p < 0.001) and fellow eyes (r(36) = -0.57, p < 0.001). A statistically significant correlation was also found between axial length and lens power, indicating decreasing lens power with increasing axial length (r(36) = -0.72, p < 0.001 for amblyopic eyes and r(36) = -0.69, p < 0.001 for fellow eyes). We observed that the correlation among the major oculometric parameters and their individual contribution to hyperopia in esotropic children were similar in amblyopic and non-amblyopic eyes. This finding suggests that the counterbalancing effect of greater corneal and lens power associated with shorter axial length is similar in both eyes of patients with esotropic amblyopia.
    No preview · Article · Jul 2011 · Ophthalmic and Physiological Optics
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    ABSTRACT: OBJETIVO: Descrever as características clínicas pré-operatórias dos pacientes com estrabismo secundário à orbitopatia de Graves e os resultados da cirurgia com anestesia tópica e sutura ajustável. MÉTODOS: Estudo retrospectivo realizado no Hospital das Clínicas da Universidade de São Paulo. Foram pesquisados os prontuários de todos os pacientes atendidos no ambulatório de estrabismo no período de março de 1994 a maio de 2004. Destes, foram separados aqueles com estrabismo associado à orbitopatia de Graves submetidos à cirurgia ajustável com anestesia tópica. As características clínicas pré-operatórias e os resultados cirúrgicos foram levantados a partir desta análise. RESULTADOS: Foram incluídos 13 pacientes. O tipo de desvio mais freqüentemente encontrado foi esotropia com hipotropia. Em 9 pacientes modificou-se o retrocesso programado no pré-operatório. Três casos necessitaram de uma segunda cirurgia. Após 6 meses de seguimento, 8 dos 13 pacientes estavam ortotrópicos ou com foria pequena e com algum grau de estereopsia. CONCLUSÃO: Neste estudo observou-se que 62% (8/13) dos pacientes apresentavam hipotropia com esotropia, provavelmente por causa do comprometimento associado do reto inferior e reto medial. Nove dos 13 pacientes necessitaram de ajuste no peroperatório e apenas 3 foram reoperados, indicando a importância da técnica ajustável para melhor alinhamento ocular no pós-operatório, possibilitando obter resultados mais satisfatórios.
    Preview · Article · Jun 2008 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: To report the clinical features of strabismus associated with Graves' orbitopathy, and the results of surgery with adjustable suture under drop anesthesia. The charts of 13 patients who had surgical treatment for strabismus related to Graves' orbitopathy at Hospital das Clínicas of University of São Paulo were retrospectively reviewed. Ocular motility, sensorial examination and the follow-up after strabismus correction were studied. Preoperatively, the most common type of deviation was esotropia with hypotropia. Adjustable recession was done in nine patients and a second surgery occurred in 3 patients. After follow-up of at least six months, 8 of 13 patients were orthotropic or had a small phoria with some degree of binocular vision. In this study, 62% (8/13) of patients showed hypotropia with esotropia, probably because fibrotic and restrictive muscles (medial and inferior rectus). In nine of 13 patients adjustable recession with a good postoperative alignment of the eyes was performed. Adjustment of strabismus surgery under drop anesthesia in patients with Graves' orbitopathy was successful in restoring binocular vision with minimum complications.
    No preview · Article · May 2008 · Arquivos Brasileiros de Oftalmologia
  • Mariza Polati · Roberto F S Malta · Carlos A.R. Alves
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    ABSTRACT: To analyze the hypothesis that a reduction in sensitivity of the nasal visual hemifield would lead to an increase in the nasotemporal asymmetry of the visual field in patients under two years of age with early-onset convergent strabismus in comparison with normal patients. Both eyes of 66 patients - 33 esotropes and 33 normals - were studied. Patients' age ranged from 7 to 30 years. The examination consisted of a static perimetry using the Humphrey field analyzer 700 Series' Sita Standard program. An accentuation of the nasotemporal asymmetry was seen in the 33 esotropes and was related to an evident decrease of sensitivity in the most peripheral of the points studied along the horizontal meridian of the visual field. The quantitative sum of values of sensitivity of these points showed an average reduction of -15.71% in relation to the normal patients. There was a clear accentuation of the nasotemporal asymmetry of sensitivity in esotropes when compared to normal patients. There was no difference in sensitivity between the two eyes in either normals or esotropes.
    No preview · Article · Oct 2007 · Strabismus
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    ABSTRACT: To evaluate the simplified intraoperative adjustable suture technique for horizontal strabismus surgery. Data charts of all patients who underwent horizontal strabismus surgery by the simplified intraoperative adjustable suture technique at the Strabismus Department of the "Hospital das Clínicas" of the University of São Paulo in the period from January 2001 to November 2005 were evaluated retrospectively. Using this technique, the adjustment was calculated based on the corneal light reflection, having considered the difference between the measures in the awake state and with the anesthetized patient. One hundred fifty-three patients were operated on, 73 (47.8%) cases of esotropia (ET) and 80 (52.2%) of exotropia (XT). Under anesthesia, 123 (80.4%) patients had the eye position modified: 69 (56.1%) were less esotropic, 51 (41.5%) were more exotropic and 3 (2.4%) were less exotropic. Surgery was adjusted in 60 (39.2%) patients: 30 were esotropia and 30 were exotropia. Surgical success was defined as an eso- or exodeviation within 10 prism diopters, in a follow-up period of at least 180 days. The overall success rate was 71.6%. The simplified intraoperative adjustable suture technique, described in 2003 in a study performed on 49 patients operated on by the same surgeon, was shown to be efficient in this larger series of patients operated on by different surgeons. This technique should be considered in patients who do not cooperate in other adjustment techniques, aiming at improved success rates.
    Preview · Article · Feb 2007 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: OBJETIVO: Avaliar a técnica de sutura ajustável per-operatória simplificada para a correção de desvio horizontal. MÉTODOS: Foram avaliados retrospectivamente os prontuários médicos de todos os pacientes que foram submetidos à cirurgia para correção de desvio horizontal utilizando a técnica de sutura ajustável per-operatória simplificada no setor de Motilidade Ocular Extrínseca do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo no período entre janeiro de 2001 e novembro de 2005. Por essa técnica, o ajuste foi calculado com base no reflexo luminoso na córnea, considerando a diferença entre a medida pré-operatória e sob plano anestésico profundo. RESULTADOS: Foram realizadas 153 cirurgias, sendo 73 (47,8%) casos de esotropia (ET) e 80 (52,2%) de exotropia (XT). Após a anestesia, houve alteração do desvio em 123 (80,4%) pacientes, sendo que destes, 69 (56,1%) eram esotropia que diminuíram, 51 (41,5%) eram exotropia que aumentaram e 3 (2,4%) eram exotropia que diminuíram. Foi realizado o ajuste per-operatório em 60 (39,2%) casos, sendo 30 (41,1%) casos de esotropia e 30 (37,5%) de exotropia. Os resultados pós-operatórios foram avaliados após seguimento mínimo de 180 dias, com taxa de sucesso (considerando ortotropia, sub ou supercorreção de até 10 dioptrias prismáticas) de 71,6%. CONCLUSÕES: A técnica de sutura ajustável per-operatória simplificada, que foi apresentada em 2003 em um estudo com 49 pacientes operados pelo mesmo cirurgião, mostrou-se eficiente nessa série maior de casos e realizada por diferentes cirurgiões. É proposta para pacientes que não colaboram para outras técnicas de ajuste, visando aumentar o sucesso cirúrgico.
    Preview · Article · Feb 2007 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: To evaluate the influence of compliance with treatment, severity of amblyopia and age at the beginning of treatment in patients with strabismic amblyopia submitted to patching. The data were selected from medical records of 569 patients seen at the Department of Ophthalmology, University of São Paulo during the period of 1983 to 2000. Exclusion criteria: loss of follow-up, age over 12 years, presence of nystagmus and other ocular diseases. The patients were divided into four groups according to age and classified based on the type of strabismus, compliance with treatment and severity of amblyopia. Statistical analysis was performed using Fisher's test. 198 (34.8%) patients were enrolled in the study. There was no difference regarding compliance among the age groups. The best success rate was obtained when there was good compliance with the treatment, independent of the degree of amblyopia. But worse compliance was observed among the patients with more severe amblyopia, who were the majority of patients of the study, and who showed the worst success rate. The success rate was not related to the patients' age. The study showed that compliance with patching plays a fundamental role in therapeutic efficacy. Thus, age at the beginning of treatment alone did not influence the success rate since it was possible to obtain good compliance independent of age. In addition, worse results were associated with severe amblyopia and less compliance.
    Preview · Article · Apr 2006 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: Diplopia is an infrequent complication described for retrobulbar local anesthesia. The objective of this study is to report the clinical characteristics and treatments for this surgical complication. Retrospective study of medical records. Period: 5.3 years ending February 2005. During this period, 20453 cataract surgeries were performed. The anesthesia used was retrobulbar block with ropivacaine diluted with hyaluronidase. Nineteen patients reported diplopia due to strabismus after the cataract surgical procedure and were referred for evaluation at the Extrinsic Ocular Motility Department. Persistent diplopia after cataract surgery occurred in 19 (0.093%) of the 20453 cases. The types of deviations found were: exotropia (n=3), esotropia (n=5), hypertropia (n=1), exotropia + hypertropia (n=5) and esotropia + hypertropia (n=5). Small deviations and dysfunction of the lateral rectus muscles were most commonly seen. Prism was applied to 4 patients, eye muscle surgery was the option in 8 patients, orthoptic treatment was performed in 3 patients and for 2 patients the decision was to only observe progress. Overall, binocular vision was restored in eleven of the nineteen patients. Persistent diplopia due to strabismus is an infrequent complication after cataract surgery with retrobulbar block. Etiology of this disorder of extrinsic ocular motility is variable, including mixed components. We stress the importance of adequate preoperative history of strabismus and evaluation of extrinsic ocular motility. Considering the reported incidence of this problem is as high as one in 25 cataract surgeries, one should advise the patient of the possibility of persistent postoperative diplopia and the possible need for surgical intervention and/or prism to treat the symptoms.
    No preview · Article · Feb 2006 · Binocular vision & strabismus quarterly
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    ABSTRACT: OBJETIVO: Avaliar os prontuários dos pacientes com estrabismo sensorial em aspectos variados, como etiologia, tipo e medida do desvio, correlação do tipo do desvio com a idade de aparecimento da doença de base, e resultado cirúrgico dos casos operados. MÉTODOS: Avaliação dos prontuários médicos dos pacientes com estrabismo sensorial atendidos no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - USP - no setor de Motilidade Ocular Extrínseca, no período de setembro de 1990 a julho de 2002. RESULTADOS: Foram avaliados 84 pacientes masculinos e 107 femininos; o diagnóstico mais freqüente para baixa visual foi coriorretinite atrófica em 49 casos. Oitenta e sete pacientes tinham exotropia e 97 tinham esotropia. Oitenta e dois pacientes tiveram cirurgia indicada, e 50 foram operados. Em 42 deles, foi constatado sucesso cirúrgico de 90,5% (desvio longe e perto menor ou igual a 15 dioptrias prismáticas). CONCLUSÕES: O bom resultado cirúrgico observado neste e em outros estudos reforça a necessidade da correção cirúrgica nesses casos.
    Preview · Article · Feb 2006 · Arquivos Brasileiros de Oftalmologia
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    Preview · Article · Jan 2006 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: To evaluate the charts of patients with sensorial strabismus regarding range of different aspects, such as etiology, the type and the amount of deviation, relationship between the type of deviation and the patient's age when the disease occurred and the surgical outcome. A retrospective analysis of data charts of 191 patients seen at the section of Ophthalmology at the University of São Paulo, from September 1990 to July 2002. There were 84 male and 107 female patients. The most frequent diagnosis responsible for low vision in the squinted eye was atrophic chorioretinitis in 49 patients. Eighty-seven were exotropes and 97 were esotropes. Fifty patients were operated on, but 8 of them were lost to follow-up. In 90.5% the surgical outcome was successful: less than 15 prismatic diopters of hyper or undercorrection after surgery. The good surgical outcome seen in this and other studies enhances and justifies the need for surgical correction of this type of strabismus.
    Preview · Article · Jan 2006 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: PURPOSE: To develop a neural network model for planning of the surgical strategy of patients with sensorial strabismus. METHODS: In this retrospective study, medical records of 95 patients with sensorial strabismus were reviewed. All patients were seen at the Strabismus Sector of the Hospital das Clínicas of the University of São Paulo. The neural network was designed containing 3 layers. Sixty-eight patients were used in the training and validation set, and 27 in the test set. RESULTS: In the 68 patients used in the training and validation set, 37 had exotropia, and 31 esotropia. The backpropagation approach was used for training the neural network. A learning rate of 0.6, and a tolerance error of 0.05 were used. In the 27 patients used in the test set, 18 had exotropia, and 9 had esotropia. The efficacy of the neural network was analyzed using the average of the difference between the indication supplied by the network and the original indication. In patients with exotropia, the average error was 0.4 mm (±0.4), for recession of the lateral rectus muscle, and 0.3 mm (±0.3), for the resection of the medial rectus muscle. In the esotropia group, the average error was 0.2 mm (±0.2) for the recession of the medial rectus muscle, and 0.5 mm (±0.3) for resection of the lateral rectus muscle. CONCLUSION: As the artificial neural network can simulate a biological central nervous system, and is able to carry out cognitive tasks, it can be a viable option to help the surgical planning for strabismus correction.
    Preview · Article · Jun 2004 · Arquivos Brasileiros de Oftalmologia
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    ABSTRACT: Purpose: To compare the results obtained with the use of an artificial neural network and regression analysis approach for planning the surgical strategy of patients with sensorial strabismus. Methods: In this retrospective study, medical records of 50 patients with sensorial convergent strabismus were reviewed. All patients were seen at the Strabismus section of the Hospital das Clínicas of the University of São Paulo. The neural network was designed containing 3 layers. Forty patients were used in the training and validation set of the artificial neural network, and the development of the formulas, and 10 in the test set. Results: In the 40 patients used in the training and validation set, there were 17 males and 23 females. Artificial neural network model results were more accurate and precise than regression analysis model (p<0,05) Conclusion: The neural network model obtained better results than the regression analysis approach. The artificial neural network can be a viable option to help the surgical planning of strabismus correction.
    No preview · Article · Jan 2004 · Revista brasileira de oftalmologia
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    ABSTRACT: OBJETIVO: Avaliar a eficácia de técnica simplificada de cirurgia ajustável per-operatória, sob anestesia geral, para a correção de desvios horizontais. MÉTODOS: Estudo prospectivo de 49 pacientes portadores de desvio horizontal, 22 com esotropia (ET) e 27 com exotropia (XT), da Secção de Motilidade Ocular Extrínseca da Clínica Oftalmológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Todos os pacientes foram submetidos à cirurgia utilizando-se a técnica de ajuste per-operatório. O ajuste foi realizado comparando-se a medida do desvio em milímetros (mm) do reflexo de luz na córnea no pré-operatório e a medida tomada no per-operatório, em plano anestésico profundo. Nas ET, o reflexo foi medido a partir do lado temporal do limbo e nas XT, do lado nasal. Todo o cálculo para o ajuste ou não, foi feito baseado nas medidas em milímetros, não se convertendo mm em dioptrias prismáticas, e nem se utilizando a pupila como ponto de referência. RESULTADOS: 28 pacientes (57,1%) apresentaram alteração do desvio em plano anestésico profundo. Em 25 pacientes (51,0%) foi necessária a realização do ajuste. Estabelecendo-se como critério de sucesso cirúrgico ortotropia, eso ou exotropia até 10 dioptrias prismáticas no pós-operatório após, no mínimo, 6 meses, a taxa de sucesso foi 75,6%. CONCLUSÃO: Os resultados mostraram que a técnica é eficiente. A técnica de cirurgia simplificada com ajuste per-operatório descrita pelos autores, oferece mais uma opção de tratamento cirúrgico visando diminuir o número de reoperações e aumentar a taxa de sucesso nas correções dos desvios, principalmente nos casos de mais difícil planejamento e que não colaboram para ajuste com anestesia tópica e/ou pós-operatório. Por ser técnica simplificada, pode ser mais facilmente realizada por cirurgiões menos experientes, aumentando a sua utilização em maior número de casos.
    Preview · Article · Jan 2003
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    Mariza Polati · Cíntia Fabiane Gomi

    Preview · Article · Jan 2003