Assessment of the usefulness of skin phototype and skin color as the parameter of cutaneous narrow band UVB sensitivity in psoriasis patients
Many reports have been released to assess skin types, skin colors and cutaneous sensitivity to broad band UVB or UVA.
This study was performed to investigate the usefulness of skin type and skin color as the parameter of narrow band UVB (NBUVB) sensitivity.
The minimal erythema dose (MED) of 40 psoriasis patients was investigated by irradiating several doses ranging from 200 to 1500 mJ/cm2. Before phototesting, the skin color of buttock was measured with a tristimulus colorimeter.
The median and mode value of MED of NBUVB was 950 mJ/cm2. Skin type was well correlated with the MED and there was a significant relationship between the L* value and MED, but not for the a* and b* values.
The MED value of NBUVB in our study is a basic data to set the phototherapy protocol. Our result showed that skin type and L* value might be useful for predicting the sensitivity to NBUVB irradiation.
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- "Clarys et al.10 reported that the L*value decreases and the b* value increases depending on the degree of tanning. Youn et al.6 examined a correlation between MEDs and colorimeteric values measured in constitutive skin color sites and found that the L* value decreases significantly as the MED increases. They pointed out that the objectively measured skin color was useful for predicting skin sensitivity to NBUVB. "
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ABSTRACT: The spectrophotometer is well known to be a useful tool for estimating the objective minimal erythema dose (MED) during planning of phototherapy protocol. However, only a few spectrophotometric values are used to evaluate the erythema and pigmentation of the MED site during phototesting.
To determinea new meaning of the relationships among spectrophotometric values during phototesting.
Twenty-five patients with psoriasis and 23 patients with vitiligo were selected before undergoing narrowband ultraviolet B phototherapy. We interpreted the gross findings of erythema and measured the L(*)a(*)b(*) values using a spectrophotometer at each phototest spot. We compared MEDs, basic spectrophotometric values (L(*)a(*)b(*)), and b(*)/L(*) values separately according to skin type, and determined the correlation of each spectrophotometric value and the correlation between a(*) and b(*)/L(*) values.
Among L(*)a(*)b(*) values, only b(*) values showed a statistically significant difference between the type III and IV groups (p=0.003). There was a positive correlation only between MEDs and b(*) values (p<0.05). The average b(*)/L(*)value in the type IV group was significantly higher than the type III group (p<0.05).
The higher b(*) values in type IV skin indicates that skin tanning develops more prominently than type III. The correlation between MEDs and b(*) values may signify that the skin pigmentation status is deepened with the higher MEDs. The difference in b(*)/L(*)values between type III and IV skin reflects that the b(*)/L(*)value is thought to be an index of tanning. The a(*) value, known as an index of erythema, does not influence the degree of tanning.
Available from: Wan-Taek Ju
- "A previous study reported that AD was due to an increase in the IFN-γ to IL-4 ratio (Kevin, 1994). Also, mononuclear cells of AD patients produce more cytokines (such as IL-4, IL-5, and IL-13) compared to those of healthy individuals (Patrick, 1994; Yoon et al., 2003 ). The causes of AD have not yet been clearly elucidated; however, AD is known to occur via a combination of genetic factors, imbalances in immune functions, and environmental factors. "
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ABSTRACT: This study was evaluated the antiatopic activity of silkworm feces extracts in DNCBinduced NC/Nga atopy mice. It was found that each level of IgE and histamine in blood was significantly decreased in the silkworm feces extracts treatment groups, compared with the DNCB-induced atopy control group. When the silkworm feces extracts was applied to the atopy mice, it could be observed that its skin recovered to normal condition with the skin surface being clean and smooth without any tissue. The results suggest that the application of silkworm feces extracts effect on atopic model through a inhibition of histamine emissions with reducing the levels of blood IgE in NC/Nga atopy mice.
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