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Clinical evaluation of drops and gel with provitamin B5 in postoperative treatment of cornea and conjunctiva wounds
Abstract
Vitamins B group are important ingredients of coenzymes. Provitamin B5 dexpanthenol is necessary in the processes of reconstruction of epithelium, has regenerative and anti-inflammatory properties. Objective of the study was to determine how the wounds of cornea and/or conjunctiva heal upon the application of D-panthenol/the medicine has been developed in the Faculty of Pharmacy of the Medical University of Gdańsk/.
The activity of the medicine was tested in 40 eyes in the test group, a 40 eyes in the control group did not receive D-panthenol. The degree of the objective and subjective symptoms was assessed.
The differences between the two groups commenced on the second day following the operation. Better effects were observed in patients receiving D-panthenol. Congestion and oedema of conjunctiva withdrew, the edges of wounds demonstrated smoothness and better adherence. Subjective feelings improved.
1. Provitamin B5 contained in 5% drops and 5% gel of D-panthenol effectively accelerates the processes of healing the wounds of conjunctiva and cornea.
... Recently, ophthalmic preparations have included D-panthenol in its ingredients, in order to get benefit from its healing effect, at the corneal level [19][20][21]. Yet, few studies have tackled this issue [19][20][21][22][23][24]. ...
... Recently, ophthalmic preparations have included D-panthenol in its ingredients, in order to get benefit from its healing effect, at the corneal level [19][20][21]. Yet, few studies have tackled this issue [19][20][21][22][23][24]. ...
... is encouraged pharmaceutical companies to incorporate it in ophthalmic preparations [19][20][21]. In order to assess its role, it was of great relevance to standardize all factors in comparing its effect versus a control. ...
Purpose:
To study the effect of D-panthenol (provitamin B5) on corneal epithelial healing, in cases of surface laser ablation. Patients and Methods: 45 eyes, of 45 patients undergoing laser surface ablation, received D-panthenol 2% in one eye and artificial tear drops of similar composition not containing D-panthenol in the other eye, postoperatively, for 2 months. Patients were examined daily for 3 days after the procedure. They were then examined weekly for 1 month. An additional examination was made after 2 months. Visual acuity (Log MAR) was assessed at every visit. Rate of healing (% of covered area) and subjective sensation of discomfort (scale 0-5) were assessed in the 1st 3 visits. Residual manifest cylinder (D) (as a parameter of corneal irregularity) and corneal clarity (epithelial and stromal haze) were assessed from week 1 to month 2.
Results:
During the first 3 days, both groups showed statistically nonsignificant (P > 0.05) results. From week 1 to month 2, eyes receiving D-panthenol showed better vision and less residual cylinder (P < 0.05) at week 1. For all other parameters, and at different examinations, both groups showed a statistically nonsignificant (P > 0.05) difference. Still, eyes receiving D-panthenol showed better values at the majority of the parameters tested.
Conclusion:
D-Panthenol effect on corneal epithelial regeneration is of minimal clinical relevance. A different dosage and a larger sample of patients might reveal a statistical relevance. This trial is registered with https://doi.org/10.1186/ISRCTN81441126.
... Since pharmaceutical companies have invented ophthalmic products containing dexpanthenol, they are now used in many ophthalmology departments to take advantage from their epithelial healing effect on the corneal epithelium layer [8][9][10][11]. After administration of dexpanthenol to an epithelial surface it is absorbed easily because of its alcoholic structure [12]. ...
... This similarity was parallel to our findings that the CAs in our study healed well and recovered at the same time in each group. Contrary to our study, Raczyńska et al. [10], found that dexpanthenol is more effective in epithelial healing. However, the patients they included were all had a surgery somehow for conjunctival or corneal injury. ...
... In vitro experiments with dexpanthenol have demonstrated proliferation of human fibroblasts [12]. Raczynska et al. reported that using dexpanthenol gel in corneal and conjunctival injuries accelerated the wound healing process [13]. In a cohort study by Baumeister et al., post-PRK re-epithelialization and wound healing were observed to be faster in patients where dexpanthenol gel was used compared to those where it was not used [14]. ...
Comparison of subjective symptoms of autologous serum and dexpanthenol gels after pterygium surgery
Pterjium cerrahisi sonrası otolog serum ve dekspantenol jellerin subjektif semptomlarının karşılaştırılması
Ugur Gurlevik 1* , Mehmet Citirik 2 , Erdogan Yasar 1 , Sevilay Karahan 3
1 Aksaray Training and Research Hospital/Eye Clinic, Aksaray, Turkey
2 University of Health Sciences, Ankara Ulucanlar Eye Education and Research Hospital, Ankara, Turkey 3 Hacettepe University, Medical Faculty Biostatistics Department, Ankara, Turkey
* Corresponding author: Ugur Gurlevik E-mail: ugurlevik@hotmail.com ORCID: 0000-0003-2965-481X Received: 10 August 2019 Accepted: 4 March 2020
ABSTRACT
Purpose: The aim of this study was to investigate the effect of autologous serum and dexpanthenol gel on subjective
symptoms after pterygium surgery.
Methods: An evaluation was made of patients who underwent the same technique of pterygium surgery between June 2017 and December 2017. Patients were divided into 2 groups with autologous serum used postoperatively in Group 1 (n: 18) and 5% dexpanthenol gel in Group 2 (n: 12). Evaluation was made of both groups in respect of postoperative pain, stinging, irritation, redness and graft edema.
Results: There was no statistically significant difference between the groups in respect of pain, stinging and watering on the 1st, 3rd and 7th days. A statistically significant decrease in these complaints was observed on days 3 and 7 in the group using dexpanthenol. There was no statistically significant difference between the groups on days 1, 3 and 7in respect of redness and graft edema. In both groups, a statistically significant increase was determined in these findings on days 3 and 7.
Conclusion: After pterygium surgery, many agents increase the comfort of patients. Autologous serum is the most reliable and most investigated agent. Dexpanthenolmay be an alternative to anterior segment surgery in respect of patient comfort and wound healing.
Keywords: dexpanthenol, pterygium, autologous serum, verbal pain scale
© 2020 by the authors; licensee MEDITAGEM Ltd., Turkey. This article is an open acces
... У пациентов с ССГ на фоне воспалительных состояний глаза при эпителиопатии и после травм также важно применение D-пантенола, который является предшественником витамина В 5 , его включают в состав офтальмологических препаратов с целью реализации его регенераторного действия в отношении роговичного эпителия. Препарат оказывает увлажняющий эффект и увеличивает барьерные свойства клеток [24][25][26][27][28][29][30]. В качестве метаболической терапии при дегенеративных изменениях эпителия роговицы и конъюнктивы D-пантенол рекомендуется и отечественными исследователями [31]. ...
In 2017 by the results of TFOS DEWS, dry eye syndrome (DES) was recognized as a disease that requires treatment. The leading role in DES development is given to inflammation and defects of an eye surface, instability and hyperosmolarity of tear film and neurosensory disorders. While choosing the tear substitute for the therapy of DES the focus is on an involvement of various components of DES pathogenesis: disbalance of a tear film structure and its’ disfunction, inflammation and defects of eye tissues. Purposes of treatment are restoration of tear homeostasis, breaking of a “vicious circle” of DES and achievement of a prolonged effect of the therapy, including the subjective one. Taking into consideration that inflammation is associated with most of ophthalmological diseases causing DES, it is a clear choice to prescribe tear substitutes with anti-inflammatory, wetting and regenerative properties. Treatment with combined tear substitutes affecting different components of DES pathogenesis simplifies the instillation regimen and increasing compliance.
... Niektóre preparaty sztucznych łez zawierają również substancje dodatkowe, takie jak np. dekspantenol, składnik witaminy B 5 , która pobudza regenerację nabłonka rogówki i hamuje procesy zapalne [7]. Raport DEWS II zawiera sugestie dotyczące postępowania w leczeniu ZSO oraz omówienie metod pomiarowych wraz z propozycją kolejności ich stosowania w diagnozie ZSO. ...
... The decrease in LDL is significant, as it is related to a decrease the risk of myocardial infarction and stroke [17]. drops and gel for postoperative treatment of corneal and conjunctival injuries [18]. ...
... Sin embargo, en el presente caso clínico el tratamiento incluyó una prótesis parcial removible inferior, con la ayuda de un gel a base de 1% de D-pantenol y 0,1% de triclosán aplicado 2 veces por semana en el intaglio protésico y una solución estabilizada de electrolitos (potasio, magnesio y calcio) usada como saliva artificial previo a las comidas y a la colocación de la prótesis removible. El Dpantenol (provitamina B 5 ), se reporta que puede estimular la proliferación epitelial, acelerar la cicatrización y hasta retrasar signos de envejecimiento 15,16 . Por su parte, el triclosán es una agente antibacteriano de amplio espectro, con un significativo efecto antiinflamatorio, adicionado a cremas dentales para un efecto anti-placa, anti-gingivitis, y prevenir la aparición y progresión de enfermedad periodontal 17,18 . ...
The CREST syndrome is characterized by calcinosis, Raynaud's syndrome, esophageal dysmotility, sclerodactyly, and telangiectasia. It has signs and symptoms in the stomatognathic system that deserve consideration in its treatment. The objective of this paper is to report the oral manifestations of a case of CREST syndrome and describe the prosthetic treatment performed in the Department of Oral Rehabilitation in the National University of Colombia. The case is presented of a patient female aged 42 years, diagnosed with CREST syndrome by the treating doctor. She came to the Faculty of Dentistry for restorative treatment. The prosthodontic management included metal-ceramic crowns, fixed partial denture, and removable partial denture. The results demonstrate that conventional restorative alternatives, similar to that used in a patient without this systemic condition, while maintaining strict control of it, can be recommended.
... In contact lens care products dexpanthenol is found in CIBA Vision's Focus (SoloCare) Aqua product as a wetting and lubricity-enhancing agent and it has also been used in dry-eye products (Gobbels & Gross 1996) and has proven useful in the management of patients with corneal injuries (Raczynska et al. 2003) . ...
The spectrum of cold injuries ranges from frostnip, chilblains to severe frostbite. Cold injuries occur upon prolonged exposure to freezing temperature and are pathologically a combination of ice crystal formation in the tissue resulting in inflammation, thrombosis and ischemia in the extremities, often necessitating limb amputation in extreme cases due to tissue necrosis. Severe forms of frostbite are a cause of major concern to patients as well as the treating physician. Due to the lack of effective treatment modalities and paucity of research on prophylaxis and therapeutics of cold injuries, we developed a novel herbosomal-loaded PEG–poloxamer topical formulation (n-HPTF) employing quality-by-design (QBD) approach. Natural compounds exhibiting potent therapeutic potential for the management of cold injuries were incorporated in novel lipid vesicles (herbosomes) loaded in PEG–poloxamer polymers. The herbosomal formulation effectively creates an occlusion barrier that promotes epithelial regeneration, desmosome scale-up and angiogenesis and thus promotes rapid healing, indicating controlled release of herbosomes. Optimized novel herbosomes showed entrapment efficiency > 90% and < 300 nm mean particle size and in vitro drug permeation of about 2 µg/cm2 followed Higuchi’s release kinetics. Skin irritancy study on female Sprague–Dawley rats showed no edema or erythema. In vivo bio-efficacy study revealed significant efficacy (p < 0.05) when compared to the standard treatment groups. Graphical abstract presenting the designing and optimization of novel herbosomal-loaded PEG–poloxamer topical formulation (n-HPTF) and predictive model for the in vivo study of the developed n-HPTF on cold injury rat skin model
To determine the efficacy of dexpanthenol applied early after urethral trauma for preventing inflammation and spongiofibrosis.
Twenty-seven rats were randomized and divided into 3 groups, with 9 rats in each group. The urethras of all rats were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14 days, group I was given 0.9% saline twice a day (control group), group II was given dexpanthenol 500 mg/kg ampules once a day and 0.9% saline once a day, and group III was given dexpanthenol 500 mg/kg ampules twice a day intraurethrally using a 22 ga catheter sheath. On day 15, the penises of the rats were degloved to perform penectomy.
The mean fibrosis scores were 2.4, 2.2, and 1.4, and mean inflammation scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for inflammation (P = .011); however, the difference for fibrosis was not significant (P = .331). The differences between groups I and III were statistically significantly different both for inflammation and fibrosis (P = .004 and P = .003, respectively). Groups II and III were not different significantly for inflammation (P = .638); however, there was less fibrosis in group III, in which high-dose dexpanthenol was administered.
We showed that dexpanthenol applied early after urethral trauma significantly decreased inflammation and spongiofibrosis. We hope that our study will help to decrease strictures after urethral trauma and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.
Copyright © 2015 Elsevier Inc. All rights reserved.
Functional constipation is not a life-threatening disease, but as a chronic state it worries the patient and causes him discomfort and often leads him to self-medication with potentially dangerous drugs. Ro 01-4709 contains as active substance dexpanthenol, which is the alcohol of pantothenic acid, a vitamin of the B-complex. In the cells, dexpanthenol is readily oxidized to pantothenic acid, which stimulates peristalsis when administered in therapeutically effective doses. Ro 01-4709 has already proven its efficacy in the prevention and treatment of adynamic ileus. Recently, several open and two double-blind studies have been carried out, investigating the efficacy of oral Ro 01-4709 in the treatment of chronic functional constipation. The two double-blind studies showed Ro 01-4709 to be superior to placebo in all parameters measured. The studies with an open design also demonstrated a favourable effect of Ro 01-4709 in the treatment of chronic functional constipation. Owing to its physiological action-which is in a favourable contrast to that of normal laxatives. Ro 01-4709 can be recommended for the treatment of functional constipation in pregnant women, children and the elderly.
In this controlled, randomized, double-masked study the effect of dexpanthenol-containing artificial tears (Siccaprotect) on patients with dry eyes was examined.
50 patients applied either dexpanthenol-containing artificial tears (Siccaprotect) or the identical, but free of dexpanthenol, eye drops five times daily into the conjunctival sac. No other ophthalmics were administered. The corneal epithelial permeability was measured by fluorophotometry and Schirmer-Test, Rose Bengal staining, tear film break-up time and the patients' subjective complaints were determined before and after 6 weeks of treatment.
The dexpanthenol-containing artificial tears (Siccaprotect) improved disturbances of the corneal epithelial permeability significantly in comparison to the dexpanthenol-free eyes drops. The other parameters didn't show relevant differences.
These data suggest that, in dry eyes, treatment with dexpanthenol-containing eye drops leads to a favorable and comparing with dexpanthenol-free eye drops superior improvement in disturbances of corneal epithelium permeability.