Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas

ArticleinApmis 111(11):1011-8 · December 2003with2 Reads
DOI: 10.1111/j.1600-0463.2003.apm1111103.x · Source: PubMed
Angiogenesis is a key process in tumour growth and metastasis, and Factor-VIII microvascular density has been found to influence prognosis among endometrial carcinoma patients. The CD105/endoglin antibody has been reported to preferentially bind to activated endothelial cells in tissues participating in angiogenesis, and we therefore wanted to compare the prognostic significance of CD105/endoglin to that of Factor-VIII. In a population-based endometrial carcinoma study with long (median 11.5 years) and complete patient follow-up, mean intratumour microvascular density (MVD) assessed using CD105/endoglin was investigated and compared with previous data for MVD assessed using Factor-VIII. MVD by CD105/endoglin was significantly correlated with MVD by Factor-VIII (p=0.001). However, tumours within the two groups defined by the upper and lower quartiles for CD105/endoglin-MVD were both significantly more often metastatic (FIGO-stage III/IV; p=0.03), with high tumour cell proliferation by Ki67 (p=0.007) and with reduced survival (p=0.036) as compared with the intermediate groups. In Cox regression analysis, CD105/endoglin-MVD showed independent prognostic influence when analysed together with patient age, FIGO stage, histologic subtype, histologic grade and Factor-VIII-MVD, while the latter lost its prognostic impact when CD105/endoglin was included. In the subgroup with high MVD, there was a tendency towards improved response to radiation therapy. In conclusion, CD105/endoglin-MVD is significantly associated with FIGO stage, tumour proliferation and prognosis in endometrial carcinoma, indicating that this is a better angiogenic marker in these tumours.
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    • Agrawal et al. reported that the ratio of p53/ Endoglin expression was associated with bladder recurrence in pTa and pT1 bladder cancer, but that Endoglin alone was not associated with bladder recurrence [20]. Also, in gastric and endometrial cancers, elevated level of Endoglin in blood serum, as well as in urine, can be seen [21,22]. Similar results have been reported in lung, prostatic, colorectal and breast cancers [23][24].
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    Full-text · Article · Jun 2016
    • However such correlation has not been found in gallbladder[53]and hepatocellular carcinoma[54]. Through CD105, no significant association between MVD and p53 has been detected in ovarian[55]and endometrial cancer[56]. All these authors, except Takahashi et al., used p53 as a dichotomized variable[52].
    [Show abstract] [Hide abstract] ABSTRACT: Multistep carcinogenesis involves loss of function of tumor suppressor proteins such as p53 and induction of angiogenesis. Such mechanisms contribute to cutaneous squamous cell carcinoma progression and may be interconnected. We aimed to explore p53 immunoexpression in spectral stages of cutaneous squamous cell carcinoma and correlate expression to both neovascularization and cellular proliferation. We estimated the percentages of immunostained cells for p53 and Ki67 (proliferation marker) in three groups: 23 solar keratoses, 28 superficially invasive squamous cell carcinomas and 28 invasive squamous cell carcinomas. The Chalkley method was used to quantify the microvascular area by neoangiogenesis (CD105) immunomarker in each group. There was no significant difference for rate of p53- and Ki67-positive cells between groups. Significant positive correlation was found between the CD105 microvascular area and the rate of p53 positive cells in superficially invasive squamous cell carcinoma as well as between the rate of p53- and Ki67-positive cells in invasive squamous cell carcinoma. p53 and Ki67 immunoexpression did not increase with cutaneous squamous cell carcinoma progression. Neovascularization in the initial stage of invasion and proliferative activity in the frankly invasive stage were both associated with p53 immunoexpression. Loss of p53 tumor suppressor function through progressive steps may be directly involved in skin carcinogenesis.
    Full-text · Article · Jul 2015
    • A significant limitation is the variation in the methods for reporting the topography of the mast cells and macrophages (31). In addition, labeling the vessels for CD31 (24,25,27,28) or CD105 (33,34), the mast cells for tryptase (24,25,35), toluidine blue (27) or C-kit (26) and the macrophages for CD68 (29–31) or CD163 (28) may cause discrepancies.
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    Full-text · Article · Aug 2013
    • These results were presented by Santos et al. [20] and Agrawal et al. [21]. Also, an elevated level of endoglin in blood serum, as well as in urine, can be typical of gastric (Salvensen et al. [22]) and endometrial cancers (Nikiteas et al. [23]). In our study, overexpression of BRIC5 was discovered in urine samples from patients with BC and compared to BRIC5 level in healthy people and revealed a statistically significant difference.
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    Full-text · Article · Sep 2012
    • Endoglin expression is a better prognostic marker than other traditional vessels markers, such as CD31 and CD34 [29, 32, 36, 38, 41]. In various tumours endoglin overexpression was associated with lower patient survival rates, presence of node metastases and distant metastatic disease2930313233343738394041. Endoglin has been examined as a target of antiangiogenic and antitumor therapy [25, 28].
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    Full-text · Article · Feb 2012
    • The transition from small dormant tumors to actively growing, invasive and metastatic tumors is shown to be associated with the so-called angiogenic switch, which implies that cancer cells gain the ability to induce formation of new blood vessels [7, 48]. Blood vessel density is further found to correlate with invasiveness and metastasis of many cancers49505152 . We therefore hypothesized that the differences in growth rate and invasiveness between the tongue and skin tumors in our experiments could be explained by a difference in vascularisation of the tumors in the two organs.
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