Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid microsatellite analysis

ArticleinObstetrics and Gynecology 102(5 Pt 1):991-4 · December 2003with6 Reads
Impact Factor: 5.18 · DOI: 10.1016/S0029-7844(03)00224-2 · Source: PubMed


    Recent developments in genetic analysis allow determination of the origin of choriocarcinoma (ie, gestational or nongestational), which helps determine the strategy for clinical treatment of the disease.
    We present a case of ovarian choriocarcinoma forming a huge ovarian mass 40 days after the patient's last menstrual period. Deoxyribonucleic acid microsatellite analysis of the tumor revealed that it contained a single maternal and two paternal alleles at several independent loci, consistent with the tumor resulting from ovarian pregnancy of a partial hydatidiform mole.
    This is the first description of an ovarian pregnancy of a partial hydatidiform mole-derived ovarian choriocarcinoma.