Antiparasitic activities of medicinal plant used in Ivory Coast. J Ethnopharmacol

Muséum National d'Histoire Naturelle, Lutetia Parisorum, Île-de-France, France
Journal of Ethnopharmacology (Impact Factor: 3). 02/2004; 90(1):91-7. DOI: 10.1016/j.jep.2003.09.029
Source: PubMed


During an ethnopharmacological survey of antiparasitic medicinal plants used in Ivory Coast, 17 plants were identified and collected. Polar, non-polar and alkaloidic extracts of various parts of these species were evaluated in vitro in an antiparasitic drug screening. Antimalarial, leishmanicidal, trypanocidal, antihelminthiasis and antiscabies activities were determined. Among the selected plants, Anogeissus leiocarpus and Terminalia glaucescens were strongly active against Plasmodium falciparum. Lawsonia inermis, selectively prescribed against trypanosomiasis shows interesting trypanocidal activities as did other 15 plants. Anthelmintic activities were found for 10 active species and 2 species (Uvaria afzelli and Monodora myristica) were actives against mites.

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    • "Medicinal plants offer the most suitable Contents lists available at ScienceDirect journal homepage: are an important source for the discovery of new antibiotics (Okpekon et al., 2004); some traditional remedies have already been produced compounds that are effective against antibioticresistant strains of bacteria (Kone et al., 2004). "

    Full-text · Dataset · Dec 2015
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    • "In Nigeria, C. sieberiana, M. oleifera, S. latifolius, and S. siamea are used (Adebayo and Krettli, 2011). U. afzelii is used by traditional healers from Cote d'Ivoire (Ménan et al., 2006; Okpekon et al., 2004). "
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    ABSTRACT: Abstract Ethnopharmacological relevance Most adults in West Africa treat acute febrile illnesses with local herbs, but the patterns of herbs used for malaria have not been recently described in Sierra Leone. Materials and methods We used a population-based cross-sectional approach to interview 810 randomly-sampled rural and urban adult residents of Bo, Sierra Leone, in December 2013 and January 2014 about their use of herbal remedies when they suspect they have malaria. Results In total, 55% of the participants reported taking one or more of seven herbs to treat symptoms of malaria. Among herb users, the most commonly used anti-malarial herbs were Moringa oleifera (moringa, 52%) and Sarcocephalus latifolius (yumbuyambay, 50%). The other herbs used included Senna siamea (shekutoure, 18%), Cassia sieberiana (gbangba, 18%), Uvaria afzelii (gone-botai, 14%), Morinda chrysorhiza (njasui, 14%), and Craterispermum laurinum (nyelleh, 7%). Combination herbal therapy was common, with 37% of herb users taking two or more herbs together when ill with suspected malaria. Conclusions Indigenous medical knowledge about herbal remedies and combinations of local herbs remains an integral part of malaria case management in Sierra Leone.
    Full-text · Article · Mar 2015 · Journal of Ethnopharmacology
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    • "Malvaceae Pinworm, roundworm Leaves Poultice with lemon strongly active against the nematode Trichuris muris (minimum lethal concentration 10 mg/mL in vitro and a worm burden reduction of 85.3% in vivo) and moderately active against Schistosoma mansoni (Koné et al., 2012). Activity of methanolic extracts from the leaves and roots of Paullinia pinnata against the free-living nematode Rhabditis pseudoelongata (EC 50 ¼2.5 mg/mL) was reported by Okpekon et al. (2004). Nguyen et al. (2009) tested a methanolic extract of the leaves of Phyllanthus urinaria against the plant parasite Bursaphelenchus xylophilus at a concentration of 10 mg/mL, but despite a significant reduction in the motility of the worms, no lethal effects could be observed. "
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    ABSTRACT: Ethnopharmacological relevance: Infections with helminths are still a big problem in many parts of the world. The majority of the people in West Africa treat such infections with medicinal plants related to the local traditional medicine. The present study aims at identifying medicinal plants traditionally used for worm infections in the Ashanti region, Ghana. In vitro screening of selected extracts from plants on which scientific knowledge is limited was to be performed. Materials and methods: Validated questionnaires were administered to 50 traditional healers in the Ashanti region, Ghana. Interviews and structured conversations were used to obtain relevant information. Quantitative and qualitative evaluation was performed additionally to structured cross-referencing of the data using SciFinder(®) data base. Selected plant species were used for in vitro testing on anthelmintic activity against the free-living model nematode Caenorhabditis elegans. Results: 35 plant species were recorded for the use in humans and 6 for the use in animals. Plant material most frequently used were the seeds from Carica papaya, mentioned by nearly all healers. The plausibility of most plants used for treatment of infections with helminths was given in most cases by documentation of potential anthelmintic activity in recent scientific literature. 9 species from plants not or scarcely described in literature for this indication were investigated on in vitro activity. A hydroethanolic (1:1) extract of Combretum mucronatum was most active with a survival rate of nematodes of 89% at 0.1mg/mL and 58% at 1mg/mL respectively (levamisole 16%). Extracts of Paullinia pinnata and Phyllanthus urinaria were also assessed to exhibit a minor (85% and 89% respectively at 1mg/mL), but still significant activity. Conclusion: Traditional use of anthelmintic plants from Ghana can be well rationalized by cross-referencing with published literature and phytochemical/pharmacological plausibility.The in vitro investigations of extracts from Combretum mucronatum, Paullinia pinnata and Phyllanthus urinaria exhibited significant effects against nematodes. The anthelmintic activity of these plants should be investigated in detail for pinpointing the respective lead structures responsible for the activity.
    Full-text · Article · Oct 2014 · Journal of Ethnopharmacology
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