Effects of Duloxetine on Painful Physical Symptoms Associated With Depression

ArticleinPsychosomatics 45(1):17-28 · March 2004with13 Reads
DOI: 10.1176/appi.psy.45.1.17 · Source: PubMed
Painful physical symptoms are common features of major depressive disorder and may be the presenting complaints in primary care settings. The effect of the dual serotonin (5-HT) and norepinephrine reuptake inhibitor duloxetine on emotional and painful physical symptoms in outpatients with major depressive disorder was evaluated in three randomized, double-blind, placebo-controlled trials. The trials' primary objective was to evaluate the effect of duloxetine on mood, and subjects were not enrolled on the basis of presence, type, or severity of pain. However, the pain-relieving effects of duloxetine were evaluated by a priori defined analyses of results from a visual analogue scale and the Somatic Symptom Inventory. Compared with placebo, duloxetine was associated with significant reduction in pain severity. The authors concluded that duloxetine reduces the painful physical symptoms of depression.
    • "In an RCT conducted by Perahia et al. on 392 patients, the analgesic and antidepressant efficacy of duloxetine 80-120 mg was evaluated in both acute and long term phase compared with paroxetine 20 mg [63]. Similar results were obtained by Goldstein et al. [61,62,64,65] who in three RCT on 353, 245, and 267 patients showed a higher antidepressant and antalgic efficacy of duloxetine 80 mg compared with duloxetine 40 and paroxetine 20, and then a higher antidepressant and antalgic efficacy of duloxetine 60 mg in a single administration compared with placebo. Numerous clinical studies suggest that SRNI have a direct analgesic effect independently from their antidepressant effect [66,67] both in patients with higher depressive and somatoform disorders [68] and in patients with trigeminal neuralgia. "
    [Show abstract] [Hide abstract] ABSTRACT: Background and Objective: Frequently patients with chronic pain show depressive disorders. The co-morbidity of pain and depressive disorders has a negative impact on the patient's outcome, with an increase of the costs relating to health expenses, a reduction of productivity and a reduction of a probable remission of depressive symptoms. Following the evidences till now examined and reported, the study group elaborated recommendations for the pain and depressive disorder treatment. Databases and Data Treatment: We searched all potentially relevant publications in Medline database from 1990 to 2014. A quality assessment was conducted categorizing following a power of evidence criteria. Results: Forty-six relevant publications were identified: 34 randomized and controlled studies (RCT), 11 meta-analyses or reviews of literature and 1 observational open-label. Conclusions: In a condition of co-morbidity of chronic pain and depressive disorder there is poor evidence for the tricyclic antidepressant efficacy. Among the inhibitors of the serotonin-noradrenalin reuptake, duloxetine proved to be efficient in the short-long term treatment of the pain and depressive disorder states. There is poor evidence for the inhibitor use of serotonin re-uptake in the co-morbidity states of arthritis pain and depressive disorder, against their higher efficacy in the irritable bowel syndrome.
    Full-text · Article · Jun 2015 · Open Journal of Depression
    • "This will facilitate generalization and implementation of results of this study. Furthermore, patients included in this study are screened for pain symptoms, differentiating between nociceptive and neuropathic pain, unlike the studies of Goldstein et al. [107] . Therefore, pain relief can be thoroughly evaluated. "
    [Show abstract] [Hide abstract] ABSTRACT: The comorbidity of pain and depression is associated with high disease burden for patients in terms of disability, wellbeing, and use of medical care. Patients with major and minor depression often present themselves with pain to a general practitioner and recognition of depression in such cases is low, but evolving. Also, physical symptoms, including pain, in major depressive disorder, predict a poorer response to treatment. A multi-faceted, patient-tailored treatment programme, like collaborative care, is promising. However, treatment of chronic pain conditions in depressive patients has, so far, received limited attention in research. Cost effectiveness of an integrated approach of pain in depressed patients has not been studied. This article describes the aims and design of a study to evaluate effects and costs of collaborative care with the antidepressant duloxetine for patients with pain symptoms and a depressive disorder, compared to collaborative care with placebo and compared to duloxetine alone. This study is a placebo controlled double blind, three armed randomized multi centre trial. Patients with (sub)chronic pain and a depressive disorder are randomized to either a) collaborative care with duloxetine, b) collaborative care with placebo or c) duloxetine alone. 189 completers are needed to attain sufficient power to show a clinically significant effect of 0.6 SD on the primary outcome measures (PHQ-9 score). Data on depression, anxiety, mental and physical health, medication adherence, medication tolerability, quality of life, patient-doctor relationship, coping, health resource use and productivity will be collected at baseline and after three, six, nine and twelve months. In the collaborative care conditions a) and b), a care-manager provides Problem Solving Treatment and integrated symptom management guidance with a self-help manual, monitors depressive and pain symptoms, and refers patients to a physiotherapist for treatment according to a 'Graded Activity' protocol. A psychiatrist provides duloxetine or placebo and pain medication according to algorithms, and also monitors pain and depressive symptoms. In condition c), the psychiatrist prescribes duloxetine without collaborative care. After 12 weeks, the patient is referred back to the general practitioner with a consultation letter, with information for further treatment of the patient. This study enables us to show the value of a closely monitored integrated treatment model above usual pharmacological treatment. Furthermore, a comparison with a placebo arm enables us to evaluate effectiveness of duloxetine in this population in a real life setting. Also, this study will provide evidence-based treatments and tools for their implementation in practice. This will facilitate generalization and implementation of results of this study. Moreover, patients included in this study are screened for pain symptoms, differentiating between nociceptive and neuropathic pain. Therefore, pain relief can be thoroughly evaluated. Trial registration NTR1089
    Full-text · Article · May 2013
    • "Mean changes at endpoint in depression rating scales (HAMD-17 and CGI-S) also did not differ significantly between duloxetine (60 mg) and placebo treatment groups. A summary of pooled data from 3 clinical trials, however, found that, compared with placebo, duloxetine was associated with significant reduction in pain severity (Goldstein et al., 2004). Perahia et al. (2008b) found that patients who did not respond to initial treatment with an SSRI and were switched to duloxetine (60 mg/day) saw significant improvement in VAS overall pain scores. "
    Full-text · Article · Jan 2013
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