Tumor necrosis factor: an apoptosis JuNKie?

Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Cell (Impact Factor: 32.24). 03/2004; 116(4):491-7.
Source: PubMed


TNF's main function is to stimulate inflammation by turning on gene transcription through the IKK/NFkappaB and JNK/AP-1 signaling cascades. TNF also can trigger apoptosis through caspase-8, but the role and underlying mechanism of this activity are not fully understood. Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF.

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Available from: Avi Ashkenazi
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