Herpes Simplex Virus

Division of Pediatric Infectious Disease, University of Virginia, Charlottesville, Virginia, United States
Pediatrics in Review (Impact Factor: 0.82). 04/2004; 25(3):86-93. DOI: 10.1542/pir.25-3-86
Source: PubMed


HSV infections vary in presentation and management among neonates, children, and adolescents. Early consideration and treatment for neonatal disease is essential. Clinical diagnosis alone usually is adequate for most of the mucocutaneous HSV presentations in childhood and adolescence. The case of antiviral therapy administration has improved, although delays in diagnosis and the overwhelming clinical manifestations of invasive HSV disease make this a devastating illness, particularly in the newborn and immunocompromised patient.

Download full-text


Available from: Linda Ann Waggoner-Fountain, Apr 08, 2014
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Several viruses are able to infect eyes and ocular adnexa of vertebrates. Considering the variety of cells and tissues comprising eyes and adnexa, viruses have multiple opportunities to colonize them and to induce a pathologic effect. This also varies depending on the animal species, age, immune status, virus species and type. Viruses may target conjunctival, glandular, corneal and/or retinal epithelium, endothelium, myocytes and pericytes, retinal and optic nerve neurons, fibers and glial cells, and lymphocytes, macrophages and dendritic cells of lymphoid follicles. Cell injury can be induced by direct cytopathic effect or via inflammatory mediator release and/or protelytic enzymes released by inflammatory cells or the injury may result from the intraparietal vascular deposition of antigen antibody complexes and following complement activation. In fetuses and youngsters some agents are able to induce various degrees of ocular dysplasia. Immunodeficiency viruses favor the colonization and growth of other agents such as other viruses, bacteria, protozoa and mycetes. Leukemia oncornaviruses can cause neoplastic lymphocytic infiltration of eyes and adnexa. This review includes viruses able to affect multiple species of vertebrates, and others specific to ruminants, horses, pigs, marsupials, dogs, cats, minks, rabbits, rats, birds and fish. Herpesvirus, arterivirus, orbivirus, paramyxovirus, morbillivirus, nodavirus, pestivirus, asfivirus, orthomyxovirus, retrovirus, lentivirus, adenovirus, calicivirus, coronavirus, reovirus and prions are discusses. Zoonotic agents include influenza orthomyxoviruses, Newcastle disease paramyxovirus, rabies rhabdovirus, transmissible bovine spongiform encephalopathy prion, simian immunodeficiency lentivirus, cercopithecine herpesvirus 1 and perhaps Borna disease virus. Anthropozoonoses include human measles morbillivirus and herpes simplex virus.
    Full-text · Article · Jun 2004

  • No preview · Article · Jan 2005 · Klinische Pädiatrie
  • [Show abstract] [Hide abstract]
    ABSTRACT: Inhibitory effects of ethanolic extracts from 10 Chinese herbs on herpes simplex virus type 1 (HSV-1) replication were investigated. By a bioassay-guided fractionation procedure, NN-B-5 was identified from seeds of N. nucifera. NN-B-5 significantly blocked HSV-1 multiplication in HeLa cells without apparent cytotoxicity. To elucidate the point in HSV-1 replication where arrest occurred, a set of key regulatory events leading to the viral multiplication was examined, including HSV-1 DNA synthesis and viral immediate early gene expressions. Data from polymerase chain reaction and Southern blotting showed that there were impairments of HSV-1 DNA replication in HeLa cells treated with NN-B-5. Results indicated that the production and mRNA transcription of infected cell protein (ICP) 0 and ICP4 were decreased in NN-B-5 treated HeLa cells. Results of an electrophoretic mobility shift assay demonstrated that NN-B-5 interrupted the formation of alpha-trans-induction factor/C1/Oct-1/GARAT multiprotein/DNA complexes. The mechanisms of antiviral action of NN-B-5 seem to be mediated, at least in part, through inhibition of immediate early transcripts, such as ICP0 and ICP4 mRNA and then blocking of all downstream viral products accumulation and progeny HSV-1 production.
    No preview · Article · Jan 2006 · Journal of Biomedical Science
Show more