Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation

Cátedra de Química Biológica, National University of Cordoba, Argentina, Córdoba, Cordoba, Argentina
International Immunopharmacology (Impact Factor: 2.47). 04/2004; 4(3):411-8. DOI: 10.1016/j.intimp.2003.12.016
Source: PubMed


In this study, we tested the antiproliferative effects of mannan from Aloe saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral cell lines. Employing flow cytometry, it could be determined that mannan inhibits the proliferative response in normal and tumoral cells. Mannan affects the expression of CD3(+) SpMC indicating that mannan inhibits mainly T lymphocyte proliferative response. Also in SpMC cultured with or without mitogen mannan produces an increase of an activation marker (CD25). On C1498 cell line, mannan reduces CD3 expression and abolishes the CD25 expression. In conclusion, mannan has a dual beneficial effect when applied to normal and tumoral cells at the same time by inhibiting the activation of cancer cells and improving that of normal ones.

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    • "In this regard, recent progress has been achieved on the identification and commercial application of plant phytonutrients possessing immunoenhancing activities, particularly in boosting innate immunity against infectious diseases and tumors [1] [2] [3] [4] [5]. For example, dandelion leaf and shiitake mushroom have been shown to stimulate lymphocyte proliferation and inhibit tumor cell growth [6] [7] [8], and a crude extract of Withania somnifera (an Ayurvedic medicinal herb commonly known as ashwagandha) exhibited immunoregulatory effects in mice [9]. "
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