Persistence of Vaccine‐Induced Antibody to Measles 26–33 Years after Vaccination

The Journal of Infectious Diseases (Impact Factor: 6). 05/2004; 189 Suppl 1(s1):S123-30. DOI: 10.1086/380308
Source: PubMed


Because measles-specific antibody titer after vaccination is lower than after natural infection, there is concern that vaccinated
persons may gradually lose protection from measles. To examine the persistence of vaccine-induced antibody, participants of
a vaccine study in 1971, with documentation of antibody 1–7 years after vaccination, were followed up in 1997–1999 to determine
the presence and titer of measles antibody. Of the 56 participants (77% were 2-dose recipients), all had antibodies detected
by the plaque reduction neutralization (PRN) antibody assay an average of 26–33 years after the first or second dose of measles
vaccine; 92% had a PRN titer considered protective (>1:120). Baseline hemagglutination inhibition antibody titer in 1971 strongly
predicted follow-up PRN antibody titer (P<.001). Persistence of antibody in these primarily 2-dose recipients supports the
current elimination strategy to achieve and sustain high population immunity with a 2-dose schedule.

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    • "Future studies will have to incorporate patients with other conditions for comparison. On the other hand, antibodies responses to viral infections and vaccines such as measles, appear to last for many years [15,16] although possibly sustained by persistent cryptic viral particles [17]. Interestingly, malaria chemoprophylaxis was associated with a slower rate of decay of antibodies to a meningococcal vaccine among Gambia children [18] suggesting that acute malaria might affect the longevity of antibodies universally. "
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    ABSTRACT: Data suggest that antibody responses to malaria parasites merozoite antigens are generally short-lived and this has implications for serological studies and malaria vaccine designs. However, precise data on the kinetics of these responses is lacking. IgG1 and IgG3 responses to five recombinant Plasmodium falciparum merozoite antigens (MSP-119, MSP-2 type A and B, AMA-1 ectodomain and EBA-175 region II) among Kenyan children were monitored using ELISA for 12 weeks after an acute episode of malaria and their half-lives estimated using an exponential decay model. The responses peaked mainly at week 1 and then decayed rapidly to very low levels within 6 weeks. Estimation of the half-lives of 40 IgG1 responses yielded a mean half-life of 9.8 days (95% CI: 7.6-12.0) while for 16 IgG3 responses it was 6.1 days (95% CI: 3.7-8.4), periods that are shorter than those normally described for the catabolic half-life of these antibody subclasses. This study indicates antibodies against merozoite antigens have very short half-lives and this has to be taken into account when designing serological studies and vaccines based on the antigens.
    Full-text · Article · Feb 2007 · Malaria Journal
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    Article: Measles.

    Preview · Article · Jun 1981 · Canadian family physician Médecin de famille canadien
  • Article: Measles
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    ABSTRACT: The purpose of this review is to summarize important papers concerning measles disease and measles-containing vaccines published in 2004. Endemic measles has been successfully controlled in the Americas and, to a lesser extent, in Europe. This has been achieved with a high uptake of two doses of a measles-containing vaccine. Even in industrialized countries, where vaccine uptake is poor, for example Japan, the disease is still a significant cause of morbidity and mortality. Vaccine failure is predominantly due to primary vaccine failure, which may, in part, be genetic in origin and related to HLA type. Measles-containing vaccines have been shown to be associated with febrile convulsions, but there is no strong evidence of a link with atopy. There is considerable evidence that there is no causal relationship with autistic disorders. In spite of this, many parents and some professionals have concerns about the safety of the vaccines, which may lead to their underuse. It is possible to eliminate measles with a high uptake of two doses of measles-containing vaccine, but concerns about safety persist and need to be tackled. More research is required into how to do this effectively and also to elucidate the causes of vaccine failure.
    No preview · Article · Jul 2005 · Current Opinion in Infectious Diseases
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