To learn better, keep the HAT on

ArticleinNeuron 42(6):879-81 · July 2004with3 Reads
Impact Factor: 15.05 · DOI: 10.1016/j.neuron.2004.06.007 · Source: PubMed


    Long-lasting memories are known to require new transcription. Recent studies have highlighted a role for epigenetic alterations, including histone acetylation, in regulating gene expression. In this issue of Neuron, Alarcón et al. and Korzus et al. use two different mouse models of Rubinstein-Taybi syndrome to elucidate a role for the histone acetyltransferase activity of CREB binding protein (CBP) in long-term memory and plasticity.