Breast cancer in Iran: A survival analysis

Iranian Institute for Health Sciences Research, Tehran, Iran.
Asian Pacific journal of cancer prevention: APJCP (Impact Factor: 2.51). 11/2003; 5(2):223-5.
Source: PubMed


A prospective study was undertaken to examine survival in Iranian breast cancer patients. One hundred and sixty-seven breast cancer patients diagnosed in 1997 were entered into the study and followed up for five years. The mean age of the patients at diagnosis was 47.2 (SD = 13.5), ranging from 24 to 81 years. A total of 39 patients were lost in the follow-up period, leaving 128 for analysis of data. Of these, 79 were alive and 49 were dead after five years. Most patients (61%) presented with advanced disease. Using life table analysis, the overall relative 5-year survival rate was found to be 62% (SE = 0.04). In addition, after adjustment for age at diagnosis, initial treatment (mastectomy, breast conserving surgery, and neo-adjuvant therapy), and disease stage, using Cox's regression model, it was found that receiving neo-adjuvant therapy as the initial treatment was an independent predictor of poorer survival (Hazard ratio = 4.56, 95% CI 2.20-9.44, P<0.0001). The other variables (older age and late stage disease), although associated with high hazards rates, were not significant. The study findings suggest that overall relative survival rate in Iranian breast cancer patients stands between western and eastern European countries and needs to be improved. It seems that early detection and better management using standard guidelines might contribute considerably to improvement of survival in women experiencing breast cancer.

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Available from: Mariam Vahdaninia
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    • "Around 66% of invasive breast cancers occur in females over the age of 50, and 12% in women younger than age 45 (ACS, 2013b). In Iran, the some of the study findings stated that the geographical and regional determinants which will affect overall survival rate, to carry preventive activities, low level of awareness, lack of screening programs of breast cancer and early detection using standard treatment protocols [2] [3] [4]. "
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    ABSTRACT: Breast cancer is the most common of all cancers and is the leading cause of cancer deaths among women worldwide. Cancer is the second leading cause of death in worldwide, with more than 12 million new cases every year. Patients with advanced survival cancer of the stomach, bronchus, colon, ovary, or breast was treated. Cancer related mortality has been estimated to about 7.6 million in 2007. Among them, Breast cancer is the most common cancer in women all over India and accounts for 25% to 31% of all cancers in women in Indian cities. In this paper, survival pattern of cancer patients was studied and survival estimates were calculated using the Kaplan-Meier method. Log rank test was used to test the equality of the groups over the survival distribution estimates. The results of the Cox regression analysis show that the hazard ratio for death due to breast cancer in women with an age group (≤30 Years Vs ≥ 50 Years: hazard ratio = 3.704, 95% CI; 2.172–6.316), stage (Early Vs Advanced: hazard ratio = 9.635,95% CI; 4.268–21.75), grade (Poor Vs High: hazard ratio = 0.968, 95% CI; 0.292-3.209) and tumour size (≤ 2 cm Vs ≥ 5cm: hazard ratio = 13.156, 95% CI; 3.018-57.342) were significantly related to survival. The breast cancer is generally detected at advanced stages when a cure is not possible. The incidence of breast cancer increases with increasing age across the globe.
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    • "This may be correspond with inclusion of higher number of patients in our study compared to cross sectional study of Ardabil (only patients of year 2003), as well as health promotion during the previous years. The other studies from Tehran have previously reported 5-year overall breast cancer survival rates of 60% (Mousavi et al., 2011) and 62% (Vahdaninia et al., 2004). These studies were conducted on records of patients during 1998-2001 and 1997 respectively. "
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    ABSTRACT: Background: Breast cancer is the most frequently occurring cancer among Iranian women; however limited studies have been conducted to address survival rates. Objective: The objective was to examine survival rates in Tabriz (Northwest of Iran) and compare with those of data reported from other cities and countries. Methods: Survival rates were calculated for one, three, five, seven and ten years for 271 breast cancer patients referred to one university clinic during 1997-2008. Results: Survival analysis demonstrated a lower survival rate compared to western countries. Conclusions: Survival rates for our patients are similar/better than other cities in Iran, but lower than certain European countries and the US. Further studies with a higher number of patients are now required.
    Full-text · Article · Jan 2013 · Asian Pacific journal of cancer prevention: APJCP
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    • "This cancer affects Iranian women at least one decade younger than their counterparts in developed countries (6).The mortality rate of breast cancer was 5.8 per 100,000 women in Tehran in 1998 (7), 2.5 per 100,000 for female population. Estimation of five-year survival is one of the indicators used to evaluate the quality of care for different types of malignancies. "
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    ABSTRACT: Breast cancer is the most common cancer among women worldwide. Based on the latest Iranian national cancer department report, the total number of women registered with breast cancer was 6976 cases during 2007. Five year survival is one of the indicators used for evaluation of the quality for care to different types of malignancies including breast cancer. The aim of this study was to estimate survival rate of breast cancer in 6147 Iranian patients at a national level in different geographic regions. 6147 cases of breast cancer, which had telephone number and were diagnosed between 2001-2006, were called to obtain information about their life status. Survival estimates were calculated using the Kaplan-Meier method, and the survival probability was calculated for the overall cohort and in different categories of gender, age and pathologic type of tumor. Hazard ratios (HR) according to demographic and risk variables were calculated by Cox's proportional hazard model. The overall 5-year survival rate was 71.0%. The mean survival time was different between men and women, which was statistically significant. The number of men involved with breast cancer was 172 (2.8%) of all cases. The 5-year survival rate for patients in age group 41-50 years was significantly higher than other age groups (P = 0.001). The likelihood of death was higher in patients with 61 years old or more years rather than those below forty years old (HR = 1.31; 95% CI: 1.12-1.55). THE FINDINGS OF THIS STUDY MIGHT HELP IRANIAN HEALTH MANAGERS: 1) to be more conscious about geographical and regional determinants which will affect overall survival rate. 2) To carry preventive activities such as public education particularly in Iranian men. 3) To think about screening and early detection of breast cancer.
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