Neuroscience. NAD to the rescue

ArticleinScience 305(5686):954-5 · September 2004with2 Reads
Impact Factor: 33.61 · DOI: 10.1126/science.1102497 · Source: PubMed

    Abstract

    Identified 15 years ago, the
    Wld
    mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective,
    Simon
    discusses new work (
    Araki
    et al.) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and
    increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription.