Use of the caudolateral curvilinear osteophyte as an early marker for future development of osteoarthritis associated with hip dysplasia in dogs

Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
Journal of the American Veterinary Medical Association (Impact Factor: 1.56). 08/2004; 225(2):233-7. DOI: 10.2460/javma.2004.225.233
Source: PubMed


To determine the relationship between the caudolateral curvilinear osteophyte (CCO) and osteoarthritis associated with hip dysplasia in dogs.
Longitudinal cohort study.
48 Labrador Retrievers from 7 litters.
In each of 24 sex- and size-matched pairs fed the same diet, a restricted-fed dog was fed 25% less than a control dog for life. The dogs' hips were evaluated in the standard ventrodorsal hip-extended radiographic projection at 16, 30, and 52 weeks of age and then yearly for life. Histologic examination of hip joint tissues was performed on 45 dogs.
Median age at death was 11.2 years. Adjusting for feeding group, dogs with a CCO were 3.7 times as likely to develop radiographic signs of osteoarthritis than those without a CCO. Stratified by diet, 100% of the control dogs with a CCO developed radiographic signs of osteoarthritis and 55% of restricted-fed dogs with a CCO developed radiographic signs of osteoarthritis. The CCO was the first radiographic change seen in 22 of 29 (76%) dogs with osteoarthritis. Overall, 35 of 37 (95%) dogs with a CCO had histopathologic lesions of osteoarthritis.
Results indicate a relationship between a CCO on the femoral neck and subsequent development of radiographic signs of osteoarthritis in Labrador Retrievers evaluated over their life span. A CCO is an important early radiographic indication of osteoarthritis associated with canine hip dysplasia.

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    • "Hip dysplasia (HD) is a multifactorial, genetically determined biomechanical development disease (usually bilateral), characterised by inadequality formed hip joints that is later accompanied by secondary degenerative joint arthrosis. Different forms of hip dysplasia occur in various species of animals including human beings, but as an important clinical problem it is just in dogs because the hip joints form an anatomical structure that holds the caudal part of dog's body on two spherical surfaces – femoral heads, and they are involved into various body movements and positions (Morgan; 1988; Powers et al., 2004). Also, such a factor shows evidence of the importance of this problem that heredity of HD has been established in 14 generations (Белов и др.1990). "
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