Question/statement judgments: An fMRI study of intonation processing

Massachusetts Institute of Technology, Cambridge, Massachusetts, United States
Human Brain Mapping (Impact Factor: 5.97). 10/2004; 23(2):85-98. DOI: 10.1002/hbm.20042
Source: PubMed


We examined changes in fMRI BOLD signal associated with question/statement judgments in an event-related paradigm to investigate the neural basis of processing one aspect of intonation. Subjects made judgments about digitized recordings of three types of utterances: questions with rising intonation (RQ; e.g., "She was talking to her father?"), statements with a falling intonation (FS; e.g., "She was talking to her father."), and questions with a falling intonation and a word order change (FQ; e.g., "Was she talking to her father?"). Functional echo planar imaging (EPI) scans were collected from 11 normal subjects. There was increased BOLD activity in bilateral inferior frontal and temporal regions for RQ over either FQ or FS stimuli. The study provides data relevant to the location of regions responsive to intonationally marked illocutionary differences between questions and statements.

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    • "To correct for multiple spatial comparisons, we identified significant clusters of activated voxels on the basis of a Monte Carlo simulation (Doherty et al, 2004). A volume of Gaussian distributed numbers was generated for each subject, and was processed in the same manner as the real data, including volumetric smoothing, resampling onto the sphere, smoothing on the spherical surface, random effects analysis, and activation map generation. "
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