A single-centre assessment of long-term quality-of-life status after sibling allogeneic stem cell transplantation for chronic myeloid leukaemia in first chronic phase

St. James's Hospital, Dublin, Leinster, Ireland
Bone Marrow Transplantation (Impact Factor: 3.57). 10/2004; 34(6):545-56. DOI: 10.1038/sj.bmt.1704638
Source: PubMed


A total of 75 patients underwent sibling allogeneic stem cell transplantation (SCT) for chronic myeloid leukaemia in first chronic phase from 1984 to 2000. Of these patients, 51 (68%) were alive at a median follow-up of 98 months (range 34-217 months). Nine (18%) patients relapsed and seven (14%) received donor lymphocyte transfusions. Quality of life (QoL) was assessed cross-sectionally using the EORTC QLQ-C30, a Leukaemia-BMT-specific module and questionnaires on sexual functioning, fertility and late effects. A total of 46 (90%) replied. Scores for Role (P=0.018) and Cognitive (P<0.001) function were significantly lower when compared to an age-adjusted general population. Dyspnoea (P=0.022) and Financial Difficulties (P<0.001) were significantly more common in the SCT group. No difference was found for scores in the Physical, Emotional and Social domains or the overall Global Health Status/QoL. Decreased sexual functioning was found in one-third of respondents. Although most BMT recipients reported a good QoL, a minority have difficulty with reintegration into professional roles and consequent monetary problems. Identified cognitive and sexual impairments highlight the need for long-term access to psychosocial support.

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    • "Higher scores on the function and total scores represent higher HRQoL, but higher scores on the symptoms score equal low HRQoL. As expected, the distribution of the HRQoL scores deviated substantially from normality, and scores were therefore dichotomised using median splits, as described by previous authors (Hayden et al, 2004; Snyder et al, 2009 "
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    • "On the other hand, investigators have described functional impairments in 10-year survivors relative to population norms [25,29,30]. Residual difficulties reported by survivors include impairments in physical and cognitive function [24,31-33], as well as restricted role and occupational functioning [24,27,33,34]. "
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    • "Compared to siblings, survivors had a high prevalence of long-term healthrelated complications including endocrine, ocular, oral health, gastrointestinal, musculoskeletal, neurosensory and neuromotor impairment. In a non-overlapping study of 46 CML transplant recipients, investigators observed a high incidence of late cognitive deficits and an increase in psychosexual problems compared to the general population [30]. Of interest, in a third study CML patients and physicians reported an improved Quality of Life (QOL) Index score, decreased signs and symptoms of depression and less alcohol consumption at 12 months following transplant compared to the study patients' immediate pretransplant baseline [31]. "

    Preview · Article · Feb 2005 · Hematology
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