Horse-level risk factors for fatal distal limb fracture in racing Thoroughbreds in the UK

ArticleinEquine Veterinary Journal 36(6):513-9 · October 2004with51 Reads
Impact Factor: 2.37 · DOI: 10.2746/0425164044877332 · Source: PubMed
Abstract

Fractures below the level of the radius or tibia (distal limb fractures) are the most common cause of equine fatality on UK racecourses; however, little is known about their epidemiology or aetiology. Identification of risk factors could enable intervention strategies to be designed to reduce the number of fatalities. To identify horse-level risk factors for fatal distal limb fracture in Thoroughbreds on UK racecourses. A case-control study design was used. Fractures in case horses were confirmed by post mortem examination and 3 matched uninjured controls were selected from the race in which the case horse was running. One hundred and nine cases were included and information was collected about previous racing history, horse characteristics and training schedules. Conditional logistic regression was used to identify the relationship between a number of independent variables and the likelihood of fracture. Horses doing no gallop work during training and those in their first year of racing were at significantly increased risk of fracture on the racecourse. Case horses were also more likely to have trained on a sand gallop, i.e. a gallop described by trainers as being primarily composed of sand. Modifications to training schedules, specifically within the first year of racing, may have a large impact on the risk of fatal distal limb fracture on the racecourse. Horses should do some gallop work in training and our results suggest that the minimum distance galloped should be between 805-2012 m (4-10 furlongs)/week. The information from this study can be used to alter training schedules in an attempt to reduce the incidence of fatal distal limb fracture in Thoroughbred racehorses. Training should include some gallop work, and further studies, recording the exact level of work, will help to identify an optimum range of training speeds and distances which will reduce the liklihood of catastrophic fracture on the racecourse.

    • "Numerous factors contribute to musculoskeletal injury during racing and training. These factors include horse (age, sex, return to training from lay-up, toe grabs and previous injury), trainer (regimen), racetrack (surface, maintenance, temperature, moisture, hardness, racing class and race length) and jockey factors (experience) [1,8,12,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. The type of training track surface has consistently been suggested to be a very important factor, but few studies exist [1,12,28]. "
    [Show abstract] [Hide abstract] ABSTRACT: Reasons for performing studyThere is limited information regarding the impact of training track surface on the occurrence of stress fractures.Objectives To evaluate the impact of training track surface on the proportion of long bone and pelvic stress fractures associated with lameness in Thoroughbred (TB) horses in flat race training undergoing nuclear scintigraphic examination.Study DesignRetrospective study.Methods Scintigraphic examinations of TB flat racehorses were evaluated from 2 hospitals (hospital A (Toronto Equine Hospital), 2003-2009 and hospital B (George D. Widener Hospital for Large Animals, School of Veterinary Medicine, University of Pennsylvania), 1994-2006). Horses admitted to hospital A trained at a single track at which the main training surface changed from dirt to synthetic on 27 August 2006. Two distinct populations existed at hospital B, horses that trained on dirt (numerous trainers) and those that trained on turf (single trainer). All scintigraphic images were evaluated by a blinded reviewer. Fisher's exact test and logistic regression were used when appropriate and significance was p<0.05.ResultsWhen reviewing 528 scintigraphic examinations from hospital A (257 dirt and 271 synthetic, numerous trainers) there was a greater proportion of stress fractures detected in scintigraphic examinations from horses training on a synthetic surface (31.7%) compared to scintigraphic examinations from horses training on a dirt surface (23.0%) at an earlier point in time (p = 0.03). There was a greater proportion of hindlimb/pelvic and tibial stress fractures diagnosed in horses from the synthetic trained group than the dirt trained group at hospital A (p<0.04, p = 0.03, respectively).Conclusions This study provides evidence that training surface may impact the proportion of stress fractures diagnosed but other factors such as training philosophy appear to be important. Future prospective investigations to elucidate fully the relationship between training track surface and the proportion of stress fractures and other non-fatal musculoskeletal injuries are warranted.
    Full-text · Article · Apr 2014 · Equine Veterinary Journal
    • "In addition to genetic differences between the populations there are also differences in the environmental risks experienced. The risk of fracture depends on the type of racing: flat turf racing is the safest (0.4 fatal fractures/1000 starts) whilst National Hunt racing is associated with the highest risk (2.2 fatal fractures/1000 starts) [11] . The increase in environmental risk for National Hunt racehorses could make the ascertainment of genetically susceptible horses from this population more difficult, potentially decreasing the power of a genetic study. "
    [Show abstract] [Hide abstract] ABSTRACT: Thoroughbred racehorses are subject to non-traumatic distal limb bone fractures that occur during racing and exercise. Susceptibility to fracture may be due to underlying disturbances in bone metabolism which have a genetic cause. Fracture risk has been shown to be heritable in several species but this study is the first genetic analysis of fracture risk in the horse. Fracture cases (n = 269) were horses that sustained catastrophic distal limb fractures while racing on UK racecourses, necessitating euthanasia. Control horses (n = 253) were over 4 years of age, were racing during the same time period as the cases, and had no history of fracture at the time the study was carried out. The horses sampled were bred for both flat and National Hunt (NH) jump racing. 43,417 SNPs were employed to perform a genome-wide association analysis and to estimate the proportion of genetic variance attributable to the SNPs on each chromosome using restricted maximum likelihood (REML). Significant genetic variation associated with fracture risk was found on chromosomes 9, 18, 22 and 31. Three SNPs on chromosome 18 (62.05 Mb - 62.15 Mb) and one SNP on chromosome 1 (14.17 Mb) reached genome-wide significance (p < 0.05) in a genome-wide association study (GWAS). Two of the SNPs on ECA 18 were located in a haplotype block containing the gene zinc finger protein 804A (ZNF804A). One haplotype within this block has a protective effect (controls at 1.95 times less risk of fracture than cases, p = 1 x 10-4), while a second haplotype increases fracture risk (cases at 3.39 times higher risk of fracture than controls, p = 0.042). Fracture risk in the Thoroughbred horse is a complex condition with an underlying genetic basis. Multiple genomic regions contribute to susceptibility to fracture risk. This suggests there is the potential to develop SNP-based estimators for genetic risk of fracture in the Thoroughbred racehorse, using methods pioneered in livestock genetics such as genomic selection. This information would be useful to racehorse breeders and owners, enabling them to reduce the risk of injury in their horses.
    Full-text · Article · Feb 2014 · BMC Genomics
    • "In TBR, age and gender have been shown to be specific risk factors for injury development, with older animals being at increased risk of tendon and ligament traumas1314151617 and females being more at risk of stress fractures [3,5]. Racetrack surface [2,3], age [1,3,6] , gen- der [1,6,16,17], season [3,5,16], trainer [4,5,151617 , preexisting pathologies181920, accumulation of exercise at racing speed [21,22], average distance run per week [23,24], laying-up periods [2,22] and inter-race interval [2,22] have all been studied in TBR populations, with contradictory results. Also, shoeing techniques received great attention [19,25,26]; particularly one of them, the toe grab, is a recognized risk factor for MSI in TBR due to the alteration of the horse's gait at high speed [19,26]. "
    [Show abstract] [Hide abstract] ABSTRACT: There is a substantial paucity of studies concerning musculoskeletal injuries in harness Standardbred racehorses. Specifically, little is known about the epidemiology of exercise-related musculoskeletal injuries. Most studies on this subject involve Thoroughbred racehorses, whose biomechanics and racing speed differ from Standardbred, making comparisons difficult. Here, a population of Standardbred racehorses trained at the same racecourse was studied over four years and a classification system for exercise-related musculoskeletal injuries was designed. The incidence rates of musculoskeletal injuries causing horses' withdrawal from training for 15 days or longer were investigated. A mixed-effects Poisson regression model was used to estimate musculoskeletal injury rates and to describe significance of selected risk factors for exercise-related injuries in this population. A total of 356 trotter racehorses from 10 different stables contributed 8961 months at risk of musculoskeletal injuries. Four-hundred-and-twenty-nine injuries were reported and classified into 16 categories, based on their aetiology and anatomical localisation. The overall exercise-related injury rate was 4.79 per 100 horse months. When considering risk factors one by one in separate univariable analyses, we obtained the following results: rates did not differ significantly between genders and classes of age, whereas one driver seemed to cause fewer injuries than the others. Racing speed and racing intensity, as well as recent medical history, seemed to be significant risk factors (p < 0.001), while being shod or unshod during racing was not. On the other hand, when pooling several risk factors in a multivariable approach, only racing intensity turned out to be significant (p < 0.001), since racing speed and the racing intensity were partially confounded, being strongly correlated to one another. Characterizing epidemiology of exercise-related musculoskeletal injuries in trotter racehorses provides baseline incidence rate values. Incidence rates of stress fracture are lower in Standardbreds compared to Thoroughbreds, whereas the opposite is true for tendon and suspensory ligament injuries. In addition to identification of risk factors for musculoskeletal injuries among Standardbred racehorses, results suggest that racing intensity seems to be a protective predictor of risk and recent medical history could be used to identify horses at risk of injury.
    Full-text · Article · Jan 2014 · BMC Veterinary Research
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