Frost L, Vestergaard PAlcohol and risk of atrial fibrillation or flutter: a cohort study. Arch Intern Med 164(18): 1993-1998

Department of Cardiology, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark.
Archives of Internal Medicine (Impact Factor: 17.33). 11/2004; 164(18):1993-8. DOI: 10.1001/archinte.164.18.1993
Source: PubMed


The evidence for an association between alcohol consumption and risk of atrial fibrillation is conflicting.
We prospectively examined the association between alcohol consumption and risk of atrial fibrillation or flutter among 47 949 participants (mean age, 56 years) in the Danish Diet, Cancer, and Health Study. The consumption of alcohol was analyzed as sex-specific quintiles by Cox proportional hazards regression models.
The mean +/- SD consumption of alcohol per day was 28.2 +/- 25 g in men and 13.9 +/- 15 g in women. During follow-up (mean, 5.7 years), atrial fibrillation or flutter developed in 556 subjects (374 men and 182 women). After adjusting for established risk factors, there was a modest increase in risk of atrial fibrillation or flutter by increasing alcohol consumption in men. When using the lowest quintile of alcohol consumption in men as a reference, the adjusted hazard rate ratios in men in quintiles 2, 3, 4, and 5 were 1.04, 1.44, 1.25, and 1.46, respectively (P for trend, .04). When using the lowest quintile of alcohol consumption in women as a reference, the adjusted hazard rate ratios in women in quintiles 2, 3, 4, and 5 were 1.09, 1.27, 1.23, and 1.14, respectively (P for trend, .69). Inclusion of information on the frequency of alcohol consumption and the preferred source of alcohol did not change these associations.
Consumption of alcohol was associated with an increased risk of atrial fibrillation or flutter in men. In women, moderate consumption of alcohol did not seem to be associated with risk of atrial fibrillation or flutter.

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Available from: Lars Frost, Jun 15, 2015
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    • "We therefore studied AF and atrial flutter as one composite endpoint. Nevertheless, most cases were probably AF as a previous study of patients recorded in a Danish National Registry with an incident diagnosis of AF or atrial flutter, showed that only 5% had pure atrial flutter.[11] Study start dates were derived using the latter of the individual practice's up-to-standard date (GPRD-defined quality marker based on assessment of completeness, continuity and plausibility of data recording in key areas) or the patient's first registration date. "
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