Peat JK, Mihrshahi S, Kemp AS, et al. Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study

Discipline of Paediatrics and Child Health, University of Sydney, Sydney, New South Wales, Australia
Journal of Allergy and Clinical Immunology (Impact Factor: 11.48). 11/2004; 114(4):807-13. DOI: 10.1016/j.jaci.2004.06.057
Source: PubMed


Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although house dust mite allergen avoidance has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known.
To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma.
A total of 616 children at high risk of asthma were enrolled antenatally in a randomized controlled trial, and 526 children remained in the trial at age 3 years. The outcomes were symptoms of allergic disease and allergen sensitization.
There was a significant 10.0% (95% CI, 3.7-16.4) reduction in the prevalence of cough in atopic children in the active diet group ( P=.003; number needed to treat, 10) but a negligible 1.1% (95% CI, -7.1 to 9.5) reduction cough among nonatopic children. There was a 7.2% (95% CI, 10.11-14.3) reduction in sensitization to house dust mite in the active allergen avoidance group ( P=.05; number needed to treat, 14). No significant differences in wheeze were found with either intervention.
These results suggest that our interventions, designed to be used in simple public health campaigns, may have a role in preventing the development of allergic sensitization and airways disease in early childhood. This offers the prospect of reducing allergic disease in later life.

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Available from: Seema Mihrshahi, Feb 01, 2016
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    • "Maternal fish oil supplementation in pregnancy has been shown to alter neonatal T-cell cytokine production [14] and to reduce asthma risk in the offspring [15]. However, supplementation of infants with fish oil seems not to reduce allergic sensitisation or asthma [16] [17], although studies of asthma-related outcomes in older children are equivocal [18] [19]. As allergic sensitisation occurs early in life, exposures at this time are most likely to influence immune development. "
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    • "Sylibin, a naturally occurring flavonoid, was shown to possess antiallergic activities that could be ascribed to a membrane-stabilizing activity on human basophils [14]. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids seems to have a role in preventing the development of allergic sensitization and airways disease [15] and in attenuating allergen-induced asthmatic reactions [16]. Pantescal ® (Bionap, Italy) is a new nutraceutical ingredient contained in different food supplements available on the European and USA markets which are recognized for their beneficial effects in relieving allergic symptoms. "
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    ABSTRACT: Allergic diseases represent conditions affecting millions of individuals across the world. The objective of this study was to investigate the potential anti-allergic effects of a new nutraceutical ingredient, Pantescal (Bionap, Italy), contained in different food supplements. Pantescal is a mixture of plant extracts, such as Capparis spinosa, Olea europaea, Panax Ginseng and Ribes nigrum. The study was a randomized, double-blind, placebo controlled design. 60 patients allergic to common aeroallergens were chosen. Allergic patients were divided into two groups: one group was supplemented by Pantescal and the other, using a placebo formulation. Two in vitro tests were performed on blood samples taken from patients before and at 2 h, 2, 3 and 10 days after supplementation: cellular antigen stimulation test (CAST) was used to analyze the amount of sulphidoleukotrienes (SLT) production and flow-cytometric antigen stimulation test (FAST) to measure expression of basophil degranulation marker (CD63) was also performed. CAST showed that after 2 and 3 days, a slight decrease of SLT production was evident but only after 10 days did it become significant with a percentage of inhibition (P.I)=43.3%. FAST revealed that there were no statistical differences for the first 2 days after supplementation although there was an inhibitory trend in the supplemented patients. CD63 expression was significantly reduced after 10 days (P.I.=64.8%). This study suggests that Pantescal is effective in reducing allergic biomarkers such as CD63 protein and SLT in atopic subjects. The higher inhibitory effect on CD63 expression compared to SLT production allows us to hypothesize cell membrane stabilization as the main potential mechanism to explain the observed Pantescal protective effects.
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