Diagnosing ICD-10 Depressive Episodes: Superior Criterion Validity of the Patient Health Questionnaire

Regenstrief Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Psychotherapy and Psychosomatics (Impact Factor: 9.2). 01/2004; 73(6):386-90. DOI: 10.1159/000080393
Source: PubMed


Diagnosing and monitoring depression in primary care remains an issue of significant public health concern. Clinicians and researchers need to know if any one screening instrument is superior to the others in diagnosing ICD-10 depressive episodes. This study aimed to examine the criterion validity for diagnosing ICD-10 depressive episodes of the Patient Health Questionnaire (PHQ) in comparison with 2 well-established instruments, the Hospital Anxiety and Depression Scale (HADS), and the WHO Well-Being Index 5 (WBI-5).
Five hundred and one medical outpatients completed the questionnaires and had a clinical interview. The presence of a depressive episode was determined with the International Diagnostic Checklists (IDCL) for ICD-10 as the criterion standard. Coefficient kappa (kappa), sensitivities and specificities were calculated and a statistical comparison of the areas under the receiver operating characteristic curves was performed.
Diagnostic agreement between the questionnaires and the IDCL was moderate (kappa=0.34-0.56), with the highest values for the PHQ. While all 3 questionnaires had reasonable sensitivity and specificity, the operating characteristics for the PHQ were significantly superior to both the HADS and the WBI-5 (p=0.02).
Any of the 3 screening instruments can be recommended for clinical use. However, this is the first comparative study to demonstrate the diagnostic advantage of a particular depression-screening instrument using the ICD-10 diagnostic criteria. The superior criterion validity of the PHQ is likely attributable to its closer representation of the current concept of depressive disorders.

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    • "PHQ-8 and PHQ-9 scores are highly correlated and have nearly identical operating characteristics [32]. Superior criterion validity of the PHQ compared to other established self-report questionnaires was confirmed with respect to the diagnoses of " major depressive disorder " and " other depressive disorders " made by a standard interview in assessing psychiatric disorders [28] [35]. On the PHQ-8, patients are asked how often, over the last 2 weeks, they have been bothered by each of the eight core depressive symptoms. "
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    • "Most studies focused on depressive symptoms in general as indicated e.g. by the PHQ sum score [14] or diagnostic interviews. For different somatic conditions (e.g. "
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