Article

Alcohol Consumption and Metabolic Syndrome: Does the Type of Beverage Matter?

Boston University School of Medicine, Room B-612, 715 Albany Street, Boston, Massachusetts 02118, USA. .
Obesity research (Impact Factor: 4.95). 10/2004; 12(9):1375-85. DOI: 10.1038/oby.2004.174
Source: PubMed

ABSTRACT

To examine the association between total and beverage-specific alcohol consumption and the prevalence odds of metabolic syndrome (MS).
Using a cross-sectional design, we studied 4510 white participants of the National Heart, Lung, and Blood Institute Family Heart Study. We used generalized estimating equations adjusting for age, education, risk group, smoking, physical activity, diabetes mellitus, coronary heart disease, energy intake, energy from fat, fruits, and vegetables, dietary cholesterol, dietary fiber, and use of multivitamins to estimate the prevalence odds of MS by alcohol intake.
Compared with never-drinkers, multivariate odds ratios (95% confidence interval) for MS were 1.12 (0.85 to 1.49), 0.68 (0.36 to 1.28), 0.72 (0.50 to 1.03), 0.66 (0.44 to 0.99), and 0.80 (0.55 to 1.16) among men who were former drinkers and who were current drinkers of 0.1 to 2.5, 2.6 to 12.0, 12.1 to 24.0, and >24.0 g/d of alcohol, respectively (p for linear trend 0.018). Corresponding values for women were 0.86 (0.69 to 1.09), 0.80 (0.43 to 1.34), 0.47 (0.33 to 0.66), 0.47 (0.30 to 0.74), and 0.39 (0.21 to 0.74), respectively (p for trend < 0.0001). The reduced prevalence odds of MS was observed across all beverage types: compared with never-drinkers, multivariate adjusted odds ratios (95% confidence interval) of MS were 0.32 (0.14 to 0.73), 0.42 (0.23 to 0.77), 0.57 (0.30 to 1.09), and 0.56 (0.36 to 0.88) for subjects who consumed >7 drinks/wk of wine only, beer only, spirits only, and more than one type of beverage, respectively.
Our data indicate that alcohol consumption is associated with a lower prevalence of MS irrespective of the type of beverage consumed. Prospective studies are needed to confirm these findings and to assess the influence of drinking patterns on the alcohol-MS association.

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Available from: Luc Djoussé, Apr 06, 2015
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    • "The prevalence of MS in substance dependent population have been reported in the range of 5-31% (Djousse et al., 2004; Gigleux et al., 2006; Rosell et al., 2003; Santos et al., 2007; Teixeira & Rocha, 2007; Urashima et al., 2005; Villegas et al., 2004; Yoon et al., 2004; Zhu et al., 2004). Reduced levels of high density lipoprotein cholesterol (Kanjilal et al., 2008; Pereska et al., 2011), increased levels of triglycerides (Pereska et al., 2011) and increased BMI (Kanjilal et al., 2008) were significantly found to contribute to MS. "
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    ABSTRACT: Background: Substance abuse, alcohol in particular, is associated with increased risk of diabetes and metabolic syndrome (MS). The relationship between the substance abuse and MS is complex and the literature is sparse. Objective: The present research was aimed to study the prevalence and predictors of MS among inpatients with substance dependence. Method: The study was conducted in tertiary care centre in North India, in which all consecutive patients with substance dependence were recruited, who were admitted from 1st January, 2011 to 31st December, 2011. MS was assessed using International Diabetes Federation (IDF) and Modified NCEP ATP-III criteria. Results: Out of 256 subjects, 24 (9.4%) subjects met the IDF criteria and 28 (10.9%) subjects met the modified NCEP criteria for MS with higher prevalence of MS in patients with alcohol and opioid dependence (26.7%) compared to alcohol (13.1%) or opioid dependence (9.6%). The commonest abnormalities were increased triglycerides (37.5%) and increased blood pressure (33.6%). On regression analysis, body mass index was found to be the most significant predictor for the development of MS. Conclusions: MS was highest in subjects with alcohol and opioid dependence with the commonest abnormality of triglyceride and blood pressure. Hence routine screening is advisable in this population to address emerging MS.
    Full-text · Article · Aug 2013 · German Journal of Psychiatry
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    • "The prevalence rate of MS at 13.6% in the present study was within the range of 5-31% reported for subjects taking alcohol by the Western studies.[101214161819202122] In our study, the prevalence of MS was found to be highest in the alcohol dependent group and it was also in the range of MS reported earlier.[101214161819202122] Compared to the previous study from our center which was conducted in inpatient setting,[24] our study is from outpatient setting with bigger sample size (250 vs 100); MS rate is similar in alcohol group (21.6 vs 24.6%), but lower in opioid group (9.6 vs 29.3%). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Substance abuse, alcohol in particular, is associated with increased risk of diabetes and metabolic syndrome (MS). The relationship between the substance abuse and MS is complex and the literature is sparse. The present research was aimed to study the prevalence and predictors of MS among outpatients with substance dependence. Patients with substance dependence were recruited from a deaddiction center in North India, who attended outpatient clinic from 1(st) January, 2010-31(st) December, 2010. MS was assessed using International Diabetes Federation (IDF) criteria. Out of 250 subjects, 34 (13.6%) of the subjects met the IDF criteria for MS and highest being in alcohol group (21.6%). The commonest abnormality was increased triglycerides (TG; 54%) and increased waist circumference (36.8%). Age, body weight, body mass index, and obesity were significant predictor of MS. MS was highest in subjects with alcohol dependence with the commonest abnormality of TG and blood pressure. Hence, routine screening is advisable in this population to address emerging MS.
    Full-text · Article · Feb 2013 · Industrial psychiatry journal
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    • "The prevalence rate of MS in entire study sample was 9.4% by IDF criteria and 10.9% by modified NCEP ATP-III. 12.1% (IDF) and 14% (modified NCEP ATP-III) MS in the patients with alcohol dependence was within the range of 5- 31% reported for subjects taking alcohol by the Western studies (Djousse et al., 2004; Gigleux et al., 2006; Rosell et al., 2003; Santos, 2007; Teixeira & Rocha, 2007; Urashima et al., 2005; Villegas et al., 2004; Yoon et al., 2004; Zhu et al., 2004). The prevalence of MS in the patients with opioid dependence in our study was 5% (IDF) and 6% (modified NCEP ATP-III) was lower than earlier study (Mattoo et al., 2011). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Background: Substance abuse, alcohol in particular, is associated with increased risk of diabetes and metabolic syndrome (MS). The relationship between the substance abuse and MS is complex and the literature is sparse. Objective: The present research was aimed to study the prevalence and predictors of MS among inpatients with substance dependence. Method: The study was conducted in tertiary care centre in North India, in which all consecutive patients with substance dependence were recruited, who were admitted from 1st January, 2011 to 31st December, 2011. MS was assessed using International Diabetes Federation (IDF) and Modified NCEP ATP-III criteria. Results: Out of 256 subjects, 24 (9.4%) subjects met the IDF criteria and 28 (10.9%) subjects met the modified NCEP criteria for MS with higher prevalence of MS in patients with alcohol and opioid dependence (26.7%) compared to alcohol (13.1%) or opioid dependence (9.6%). The commonest abnormalities were increased triglycerides (37.5%) and increased blood pressure (33.6%). On regression analysis, body mass index was found to be the most significant predictor for the development of MS. Conclusions: MS was highest in subjects with alcohol and opioid dependence with the commonest abnormality of triglyceride and blood pressure. Hence routine screening is advisable in this population to address emerging MS.
    Full-text · Article · Jan 2013 · German Journal of Psychiatry
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