Article

Antiinflammatory and anti-nociceptive activity of water decoction of Desmodium gangeticum

Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute (Council of Scientific and Industrial Research), Rana Pratap Marg, Post Box No. 436, Lucknow 226 001, Uttar Pradesh, India.
Journal of Ethnopharmacology (Impact Factor: 3). 01/2005; 95(2-3):259-63. DOI: 10.1016/j.jep.2004.07.009
Source: PubMed

ABSTRACT

The water decoction of root and aerial parts of Desmodium gangeticum (Leguminosae) was examined for anti-inflammatory and anti-nociceptive activity in experimental animals. The root and aerial decoction in doses of 5, 10 and 20 mg /kg caused a dose-dependent inhibition of swelling caused by carrageenin equivalent to 14.58-51.02% protection and 14.43-38.67%, respectively, in cotton pellet granuloma. There was a significant increase in analgesio-meter-induced force equivalent to 6.56-67.66% protection and 22.18-73.83% protection in acetic acid-induced writhing. The result establishes the traditional use of water decoction of Desmodium gangeticum codified in Indian System of Medicine.

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    • "Other than being processed into green manures and forages, some of them can be used as herbal medicines. For example, Desmodium gangeticum has been demonstrated to possess antioxidant, anti-nociceptive, anti-inflammatory (Govindarajan et al., 2007; Rathi et al., 2004), antiemetic (Joshi and Parle, 2007), cardioprotective (Kurian and Philip, 2005), and anti-ulcer effects (Dharmani et al., 2005). "

    Preview · Article · Apr 2011 · African journal of pharmacy and pharmacology
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    • "Other than being processed into green manures and forages, some of them can be used as herbal medicines. For example, Desmodium gangeticum has been demonstrated to possess antioxidant, anti-nociceptive, anti-inflammatory (Govindarajan et al., 2007; Rathi et al., 2004), antiemetic (Joshi and Parle, 2007), cardioprotective (Kurian and Philip, 2005), and anti-ulcer effects (Dharmani et al., 2005). "
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    ABSTRACT: The aim of this study was to examine the antioxidant activities and phenolic components of the crude extracts of 10 Desmodium species from Taiwan. In this study, DPPH free radical scavenging activity, ABTS radical monocation scavenging activity, ferric-reducing antioxidant power (FRAP) and reducing power of the 10 Desmodium species were evaluated for their antioxidant activities. The results showed that, of all the samples, Desmodium sequax was the most active in ABTS, DPPH, FRAP and reducing power assays. The total polyphenol, total flavonoid and total flavonol contents of the crude extract were calculated. The correlation coefficient (R 2) values of TEAC with phenolic compounds indicated strong positive correlations, except for total flavonoid content. Furthermore, HPLC chromatographic fingerprints were established, and chlorogenic acid and vitexin in D. sequax were quantified. Chlorogenic acid was confirmed to express strong antioxidant activities in ABTS, DPPH, FRAP and reducing power assays. The present study indicated the antioxidant activities of the 10 Desmodium species were related to their phenolic components. D. sequax is a potent antioxidant medicinal plant, and chlorogenic acid may be an important factor in the antioxidant activity of this plant.
    Full-text · Article · Apr 2011 · African journal of pharmacy and pharmacology
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    • "The anti-inflammatory mechanism of Desmodium triflorum might be related to the decrease in the level of malondialdehyde (MDA) in the edema paw via increasing the activities of superoxide dismutase (SOD) and glutathione reductase (GRd) in the liver, and the reduction in the nitric oxide (NO) level via regulating the interleukin-1␤ (IL-1␤) production and the level of tumor necrosis factor-␣ (TNF-␣) in the inflamed tissues (Lai et al., 2009). The aqueous extract of root and aerial parts of Desmodium gangeticum DC. was also found to have significant anti-inflammatory and analgesic activities in experimental animals (Rathi et al., 2004). Although a number of plants belonging to the genus Desmodium have been investigated on their chemical components and "
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    ABSTRACT: Desmodium podocarpum is a plant that has been used in the folk medicine to treat febrile diseases, cough and bleeding wounds. However, there is no scientific basis or reports in the modern literature regarding its effectiveness as an analgesic, anti-inflammatory and antipyretic agent. The objective of this study is to evaluate the analgesic, anti-inflammatory and antipyretic activities of the petroleum ether fraction (PEF) from the ethanol extract of Desmodium podocarpum. PEF (50, 100, 200 mg/kg) was estimated for its pharmacological properties by using the acetic acid-induced writhing test, the hot plate test, the Carrageenan-induced rat paw edema model, the dimethylbenzene-induced mouse inflammation model, and the lipopolysaccharide (LPS)-induced rat fever model. In addition, the acute toxicity of PEF was also studied. PEF significantly and dose-dependently inhibited the writhing responses in mice, increased reaction time of mice in the hot plate test, reduced carrageenan-induced paw edema in rats and the dimethylbenzene-induced ear edema in mice, and attenuated LPS-induced fever in rats. No death of mice was observed when orally administered PEF up to 4.2 g/kg. These findings suggest that PEF possesses evident analgesic, anti-inflammatory and antipyretic activities, and has a favorable safety, which supports the use of Desmodium podocarpum as an analgesic, anti-inflammatory and antipyretic drug in the folk medicine.
    Full-text · Article · Feb 2011 · Journal of ethnopharmacology
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