pattern is combined with available bioinformatics from
Entrez gene at NCBI, Gene Ontology Consortium and other
databases available on the web. From our experience in this
project, we conclude that gene ontology functional groups
may provide a great source of candidate genes for screening
by in situ hybridization in the developing brain.
A database of expression patterns of all genes during
brain development would provide a valuable resource for the
neuroscience community. Academic and industrial research
projects would benefit from a central repository of gene
expression pattern information that would eliminate redun-
dant efforts to resolve such a primary characteristic of a gene
as its normal distribution pattern during development. Our
efforts in this project showed that expression pattern is a
fundamental component of gene function and therefore it is a
central piece of information that is critical for investigating
the role of the gene during normal development.
The authors would like to thank Shannon Dupuy-Davies
for helpful suggestions in the setup of this project and Anna
Seal, Andrew Asbury and Tony Cheung for help with in situ
hybridization processing. This work was supported in part
by NIH grant R37 NS36558 (T.C.) and the American
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