Cortical laminar necrosis in childhood intracranial germ cell tumor survivors

Department of Diagnostic Radiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Pediatric Blood & Cancer (Impact Factor: 2.39). 04/2005; 44(4):412-5. DOI: 10.1002/pbc.20270
Source: PubMed


We report two childhood germ cell tumor survivors treated for multifocal or large suprasellar tumors followed by the presentation of acute neurological deficits and extensive cortical laminar necrosis on magnetic resonance imaging (MRI), 7 and 34 months after cranial irradiation. This complication, though uncommon, represents another manifestation of delayed treatment-related brain injury that can be catastrophic and leads to significant morbidity.

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